A5013139211- Gastroesophageal reflux and treatments
- Helicobacter pylori-related gastroenterology studies
- COVID-19 Clinical Research Studies
- Pulmonary Hypertension Research and Treatments
- Pneumonia and Respiratory Infections
- Respiratory Support and Mechanisms
- Respiratory viral infections research
- Congenital Heart Disease Studies
- COVID-19 and Mental Health
- Cardiovascular and Diving-Related Complications
- Liver Disease Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Cardiovascular Function and Risk Factors
- Diet, Metabolism, and Disease
- Cancer, Lipids, and Metabolism
- Nutritional Studies and Diet
- Blood Pressure and Hypertension Studies
- Adolescent and Pediatric Healthcare
- Diet and metabolism studies
- Biomarkers in Disease Mechanisms
- Heart Failure Treatment and Management
- Cardiovascular Health and Disease Prevention
- Parathyroid Disorders and Treatments
- Metabolism, Diabetes, and Cancer
- Adenosine and Purinergic Signaling
Guangdong Provincial People's Hospital
2020-2025
Guangdong Academy of Medical Sciences
2018-2025
Southern Medical University
2023-2025
Sun Yat-sen University
2013-2024
Eighth Affiliated Hospital of Sun Yat-sen University
2020-2024
Shantou University
2017-2024
VA Sepulveda Ambulatory Care Center
2024
University of California, Los Angeles
2024
Shantou University Medical College
2020-2024
South China Sea Institute Of Oceanology
2023
Vascular calcification (VC) is regarded as an important pathological change lacking effective treatment and associated with high mortality. Sirtuin 6 (SIRT6) a member of the family, class III histone deacetylase key epigenetic regulator. SIRT6 has protective role in patients chronic kidney disease (CKD). However, exact molecular mechanism VC CKD remain unclear. Here, we demonstrated that was markedly downregulated peripheral blood mononuclear cells (PBMCs) radial artery tissue VC....
Abstract Background In the post-pandemic era, a wide range of COVID-19 sequelae is growing health concern. However, risks digestive diseases in long COVID have not been comprehensively understood. To investigate long-term risk among patients. Methods this large-scale retrospective cohort study with up to 2.6 years follow-up (median follow-up: 0.7 years), group ( n = 112,311), contemporary comparison 359,671) and historical 370,979) predated outbreak were built using UK Biobank database. Each...
BackgroundIn the post-pandemic era, growing apprehension exists regarding potential sequelae of COVID-19. However, risks respiratory diseases following SARS-CoV-2 infection have not been comprehensively understood. This study aimed to investigate whether COVID-19 increases long-term risk illness in patients with COVID-19.MethodsIn this longitudinal, population-based cohort study, we built three distinct cohorts age 37–73 years using UK Biobank database; a group diagnosed medical records...
Sustained Hif1α (hypoxic-inducible factor-1 alpha) accumulation plays a central role in osteogenic transdifferentiation and subsequent calcification. Capsaicin, the potent agonist of TRPV1 (transient receptor potential vanilloid type 1), was found to mitigate hypoxic-related injury reverse phenotypic switch vascular smooth muscle cells. However, its arterial calcification underlying mechanisms remain unexplored.We used data from Multi-Ethnic Study Atherosclerosis examine association coronary...
<title>Abstract</title> <bold>Background:</bold> Inflammatory bowel disease (IBD) is a chronic condition affecting individuals across all age groups. However, the association between IBD and biological aging remains unclear. <bold>Methods:</bold> We utilized data from UK Biobank diverse cohort of All Us (AoU) Research Programme to investigate role in development its subtypes. Biological was assessed using Klemera-Doubal method (KDMAge) phenotypic (PhenoAge), with KDMAgeAccel PhenoAgeAccel...
Background First cardiometabolic disorders (FCMDs) and dementia pose a significant burden on aging populations. Investigating the association between atmospheric pollutants progression of FCMDs is crucial. Methods A prospective analysis was conducted 413 149 participants from UK Biobank. Atmospheric pollutant concentrations were calculated using land‐use regression models. We used multistate model polygenic risk score for to analyze associations relevant trajectories baseline FCMD,...
Our understanding of the weight-outcome association mainly comes from single-time body mass index (BMI) measurement. However, data on long-term trajectories within-person changes in BMI diverse study outcomes are sparse. Therefore, this is to determine associations individual and cardiovascular outcomes.The present analysis was based 4 large prospective cohorts restricted participants aged ≥45 years with at least two measurements. Hazard ratios (HR) 95% confidence intervals(95%CI) for each...
Adverse effects of proton pump inhibitors (PPIs) have raised wide concerns. The association PPIs with influenza is unexplored, while that pneumonia or COVID-19 remains controversial. Our study aims to evaluate whether PPI use increases the risks these respiratory infections. current included 160,923 eligible participants at baseline who completed questionnaires on medication use, which histamine-2 receptor antagonist (H2RA), from UK Biobank. Cox proportional hazards regression and propensity...
<title>Abstract</title> Early identification of metabolic dysfunction-associated steatotic liver disease (MASLD) is crucial for preventing progression, yet reliable predictive tools remain lacking. We analyzed proteomics data 37,966 participants without baseline MASLD from southern United Kingdom, using multivariable Cox regression to conduct protein selection and model development. The top-ranking proteins were combined with clinical polygenic risk scores develop models. models internally...
Content and aims: Ginsenoside RG1 (RG1) is thought to enhance proliferation differentiation of stem cell, however, its role on paracrine efficacy cell remains unclear. Here we examined if how enhances the effects bone marrow-derived mesenchymal cells (BM-MSCs) radiation induced intestinal injury (RIII).Irradiated rats randomly received intraperitoneal injection conditioned medium (CM) derived from non-activated BM-MSCs (MSC-CM) or pre-activated by RG-1 (RG1-MSC-CM). Intestinal samples were...
Abstract Background Accurately stratifying patients with pulmonary arterial hypertension (PAH) is very important, and traditional risk scores still have internal heterogeneity. This study aimed to construct a stratification model that can accurately identify clinical worsening (CW) events in conventional low‐intermediate under targeted drug treatment by using echocardiographic parameters. Methods single‐center, prospective study, including 105 PAH who underwent regular follow‐up at Guangdong...
Abstract Background Lung function is constantly changing over the life course. Although relation of cross-sectional lung measure and adverse outcomes has been reported, data on longitudinal change subsequent cardiovascular (CV) events risks are scarce. Therefore, this study to determine association in risks. Methods This analyzed from four prospective cohorts. Subjects with at least two tests were included. We calculated rate forced respiratory volume 1 s (FEV1) vital capacity (FVC) decline...
Background: Vascular calcification (VC) is an important predictor of prognosis in atherosclerosis, the phenotypic transformation vascular smooth muscle cells (VSMCs) thought to be a process VC. However, implications and potential mechanisms for VSMCs transition remain unknown. Methods: To study early period, we analyzed single-cell sequencing data from carotid artery calcified core paracellular tissue, based on results enrichment analysis protein-protein interaction analysis. Upstream...
Abstract Objectives To prospectively investigate the associations of habitual fish oil use with Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, hospital admission, or mortality Corona Virus Disease-19 (COVID-19) in a large-scale cohort. Design Prospective population-based cohort study. Setting UK Biobank. Participants A total 110 440 participants aged 37 -73 years who completed questionnaire on supplement use, which included at baseline were enrolled between 2006 and...
Abstract Background For patients with congenital heart disease-related pulmonary arterial hypertension (CHD-PAH), cardiopulmonary exercise testing (CPET) can reflect reserve function. However, CPET may not be readily accessible for high-risk conditions or limited mobility due to disability. Echocardiography, on the other hand, serves as a widely available diagnostic tool all CHD-PAH patients. This study was aimed identify parameters of echocardiography that could serve indicators function...
Background: Despite the growing evidence of an association between inflammatory bowel disease (IBD) and psychiatric disorders, there has been limited research exploring underlying mediating role blood biomarkers on brain-gut axis.Methods: This prospective cohort study using data from UK Biobank included participants without diagnoses at baseline. Cox regression models estimated adjusted hazard ratios (aHRs) IBD 11 major outcomes. Causal mediation investigated potential effects...
Despite the growing evidence of an association between inflammatory bowel disease (IBD) and psychiatric disorders, there has been limited research exploring underlying mediating role blood biomarkers on gut-brain axis. This study aimed to examine IBD risk incident disorders investigate whether how mediate this association.
Patients with uncorrected isolated simple shunts associated pulmonary arterial hypertension (PAH) had increased mortality. Treatment strategies for borderline hemodynamics remain controversial. This study aims to investigate preclosure characteristics and its association postclosure outcome in this group of patients.Adults PAH were included. Peak tricuspid regurgitation velocity<2.8 m/sec normalized cardiac structures was defined as the favorable outcome. We applied unsupervised supervised...