A5100449059- Acute Myeloid Leukemia Research
- CAR-T cell therapy research
- Chronic Lymphocytic Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Immune Cell Function and Interaction
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cancer, Lipids, and Metabolism
- Virus-based gene therapy research
- Eosinophilic Disorders and Syndromes
- Hematological disorders and diagnostics
- Acute Lymphoblastic Leukemia research
- Ferroptosis and cancer prognosis
- Cancer Risks and Factors
- Inflammatory Bowel Disease
- Advanced MRI Techniques and Applications
- Platelet Disorders and Treatments
- Histone Deacetylase Inhibitors Research
- Nanowire Synthesis and Applications
- Multiple Myeloma Research and Treatments
- MicroRNA in disease regulation
- Phytochemical and Pharmacological Studies
- Bioactive natural compounds
- Gestational Trophoblastic Disease Studies
Harbin Medical University
2008-2024
Second Affiliated Hospital of Harbin Medical University
2008-2024
Guangdong Academy of Medical Sciences
2017-2024
Guangdong Provincial People's Hospital
2020-2024
Southern Medical University
2023-2024
Zhongshan Hospital
2022
Sun Yat-sen University Cancer Center
2018
Sun Yat-sen University
2018
Guangdong General Hospital
2017
The Ohio State University
2014
Acute myeloid leukemia (AML) is one of the most common types adult acute leukemia. Standard chemotherapies can induce complete remission in selected patients; however, a majority patients eventually relapse and succumb to disease. Thus, development novel therapeutics for AML urgently needed. Human C-type lectin-like molecule-1 (CLL-1) type II transmembrane glycoprotein, its expression restricted cells blasts. Moreover, CLL-1 expressed stem (LSCs), but absent hematopoietic (HSCs), which may...
Background: Emerging evidence has proven that ferroptosis plays an important role in the development of acute myeloid leukemia (AML), whereas exact ferroptosis-associated genes AML patients' prognosis remained unclear. Materials and Methods: Gene expression profiles corresponding clinical information cases were obtained from TCGA (TCGA-LAML), GEO (GSE71014), TARGET databases (TARGET-AML). Patients cohort well-grouped into two clusters based on ferroptosis-related genes, differentially...
Observational studies have indicated associations between inflammatory bowel disease (IBD) and neurodegenerative diseases, including Parkinson's (PD).To evaluate the causal of IBD with PD other selected disorders using updated data.Bidirectional two-sample Mendelian randomization genome-wide association summary statistics PD.We found a lack evidence for on (odds ratio [OR], 1.014; 95% confidence interval [CI], 0.967-1.063; P = 0.573). Reverse analysis also no effect (OR, 0.978; CI,...
Although dasatinib is effective in most imatinib mesylate (IMT)-resistant chronic myeloid leukemia (CML) patients, the underlying mechanism of its effectiveness eliminating imatinib-resistant cells only partially understood. This study investigated effects on signaling mechanisms driving-resistance CML cell line K562 (K562R(IMT)). Compared with control cells, exsomal release, phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/ mammalian target rapamycin (mTOR) and autophagic activity...
The three-dimension (3D) magnetization-prepared rapid gradient-echo (MP-RAGE) sequence is one of the most popular sequences for structural brain imaging in clinical and research settings. captures high tissue contrast provides spatial resolution with whole coverage a short scan time. In this paper, we first computed optimal k-space sampling by optimizing simulated images acquired MP-RAGE at 3.0 Tesla using computer simulations. Because software our scanner has only limited settings sampling,...
Metastatic rhabdomyosarcoma is associated with poor survival and unsatisfactory treatment outcomes. Therefore, new immunotherapeutic methods are urgently required. Fibroblast growth factor receptor 4 (FGFR4), a therapeutic target for rhabdomyosarcoma, plays crucial role in its onset development. This study aimed to generate FGFR4 single-chain variable fragment-based chimeric antigen (CAR) T cells without causing evident toxicity incorporating an inducible caspase-9 (iCasp9) suicide gene...
Abstract To understand the various effects that influence actual flip angles, and correct for these effects, it is important to precisely quantify MRI parameters (such as T 1 , 2 perfusion). In this paper angle maps are calculated using a conventional gradient‐echo (GRE) sequence with different radiofrequency (RF) pulse shapes (Gaussian, sinc, truncated‐sinc), slice‐selection gradients, off‐resonance excitations, B 0 field inhomogeneities. The experimental results demonstrate RF...
To evaluate the efficacy and safety of flumatinib in later-line treatment Chinese patients with Philadelphia chromosome-positive chronic-phase chronic myeloid leukemia (CP-CML previously treated tyrosine kinase inhibitors (TKIs). Patients CML-CP were evaluated for probabilities responses including complete hematologic response (CHR), cytogenetic response, molecular (MR) adverse events (AEs) after therapy. Of 336 enrolled median age 50 years, duration was 11.04 (2-25.23) months. who achieved...
Abstract In addition to their capacity differentiate, BM stromal cells (BMSC) have immunosuppressive qualities that make them strong candidates for use in cell therapy against human autoimmune diseases. We studied the immunoregulatory activities of BMSC on experimental myasthenia gravis (EAMG) vitro and vivo . Intravenous administration syngenic EAMG‐model rats day second immunization was effective ameliorating pathological features disease. , proliferative ability T or B from EAMG inhibited...
Glioblastoma multiforme (GBM) is one of the most malignant tumors in brain with high morbidity and mortality. Mitophagy plays a significant role carcinogenesis, metastasis, invasion. In our study, we aim to construct mitophagy-related risk model predict prognosis GBM.RNA-seq data combined clinical information were downloaded from TCGA. The 4-gene nomograph was then constructed validated external cohort. Evaluation immune infiltration, functional enrichment tumor microenvironment (TME)...
Treatment options for radiation-induced intestinal injury (RIII) are limited. Crocetin has been demonstrated to exert antioxidant, antiapoptotic, and anti-inflammatory effects on various diseases. Here, we investigate the of crocetin RIII in vitro. Materials Method. IEC-6 cells exposed 10 Gy radiation were treated with different doses (0, 0.1, 1, 10, 100 μM), cell viability was assessed by CCK-8. The levels superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx),...
Emerging evidence suggested that mitophagy may play an important role in the progression of hepatocellular carcinoma (HCC), whereas association between mitophagy-related genes and HCC patients’ prognosis remains unknown. In this study, we aimed to investigate potential prognostic values (MRGs) on patients at genetic level. According median immunoscore, categorized from TCGA cohort into two immune score groups, while 39 differential expression MRGs were identified. By using univariate...
Amyloid light chain (AL) amyloidosis is a rare plasma cell dyscrasia with dismal prognosis. This study aims to investigate the T-cell immune checkpoint expression patterns in systemic AL and its relationship clinicobiological traits. We examined frequencies of V-domain immunoglobulin suppressor T activation + (VISTA ), programmed death 1 (PD-1 mucin-domain-containing-3 (Tim-3 immunoreceptor Ig ITIM domains (TIGIT ) cells peripheral blood (PB) bone marrow (BM) from 19 patients newly diagnosed...
A new coumaronochromone derivative, sophorophenolone (1), along with 13 known compounds, l-maackiain (2), medicagol (3), 7-O-methylpseudobaptigenin (4), pseudobaptigenin (5), 7,3'-di-O-methylorobol (6), genistein (7), prunetin (8), daidzein (9), formononetin (10), Di-O-methyldaidzein (11), quercetin (12), kaempferol (13) and isorhamnetin (14) were isolated from pericarps of Sophorajaponica L. The structure compound 1 was established by UV, IR, MS, one-dimensional two-dimensional NMR...
Abstract Bioactive constituents from Rhodiola rosea L. (RRL) exhibit multiple pharmacological effects on diverse diseases. However, whether they are suitable for the treatment of radiation‐induced intestinal injury (RIII) remains unclear. This study aims to investigate their roles and mechanisms in RIII rat model. The radioprotective four bioactive RRL (salidroside, herbacetin, rosavin arbutin) were evaluated by cell viability irradiated IEC‐6 cells. Intestinal tissues collected histological...
Background New immunotherapeutic approaches are urgently needed for metastatic rhabdomyosarcoma, which is associated with poor survival and unsatisfactory treatment outcomes. Platelet‐derived growth factor receptor α (PDGFRA) plays an essential role in the onset development of rhabdomyosarcoma a new potential therapeutic target rhabdomyosarcoma. The objective this study was to generate humanized PDGFRA single‐chain variable fragment‐based chimeric antigen (CAR)‐modified T cells (CAR‐T cells)...
Background: Gastric cancer (GC) is a multifactorial progressive disease with high mortality and heterogeneous prognosis. Effective prognostic biomarkers for GC were critically needed. Hippo signaling pathway one of the critical mechanisms regulating occurrence development GC, has potential clinical application value prognosis treatment patients. However, there no effective signature based on pathway-related genes (HSPRGs) to predict response Our study aimed build HSPRGs explore its...
Lactate, produced through glycolytic metabolism in the tumor microenvironment (TME), is implicated tumorigenesis and progression diverse cancers. However, impact of lactate on remodeling TME diffuse large B-cell lymphoma (DLBCL) its implications for therapy options remain unclear.A lactate-related (LAR) scoring model was constructed DLBCL patients using bioinformatic methods. CIBERSORT, XCELL, ssGSEA algorithms were used to determine correlation between LAR score immune cell infiltration....