A5110947401- Chronic Myeloid Leukemia Treatments
- Quinazolinone synthesis and applications
- Synthesis and biological activity
- Iron Metabolism and Disorders
- Eosinophilic Disorders and Syndromes
- Pharmacological Effects of Natural Compounds
- Acute Myeloid Leukemia Research
- Bioactive Compounds and Antitumor Agents
- Synthesis of Organic Compounds
- Lung Cancer Treatments and Mutations
- Gut microbiota and health
- Magnolia and Illicium research
- PI3K/AKT/mTOR signaling in cancer
- Dialysis and Renal Disease Management
- Intergenerational and Educational Inequality Studies
- Sphingolipid Metabolism and Signaling
- Ginseng Biological Effects and Applications
- Pharmaceutical Practices and Patient Outcomes
- Prenatal Screening and Diagnostics
- Thermal and Kinetic Analysis
- Flavonoids in Medical Research
- Plant-derived Lignans Synthesis and Bioactivity
- Adenosine and Purinergic Signaling
- Mast cells and histamine
- Erythropoietin and Anemia Treatment
Chengdu University of Traditional Chinese Medicine
2023-2024
Zhongnan Hospital of Wuhan University
2022-2024
Beijing Normal University
2024
Wuhan University
2022-2024
University of South China
2017-2023
Duke University
2022-2023
Affiliated Hospital of Nantong University
2022
Nantong University
2022
First Hospital of Jilin University
2022
Jilin University
2022
Although dasatinib is effective in most imatinib mesylate (IMT)-resistant chronic myeloid leukemia (CML) patients, the underlying mechanism of its effectiveness eliminating imatinib-resistant cells only partially understood. This study investigated effects on signaling mechanisms driving-resistance CML cell line K562 (K562R(IMT)). Compared with control cells, exsomal release, phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/ mammalian target rapamycin (mTOR) and autophagic activity...
A series of chrysin benzimidazole derivatives were synthesised and evaluated for their anticancer activity in the search potential agents. Among them, compound 18 displayed most potent anti-proliferative against MFC cells with IC50 values 25.72 ± 3.95 μM. The flow cytometry results that induced apoptosis a dose-dependent manner caused cell cycle to be arrested G0/G1 phase. Furthermore, preliminary vivo was also studied tumour-bearing mice, exerted good inhibition effect on tumour growth....
Ulcerative colitis (UC), belonging to inflammatory bowel disease (IBD), is a chronic and relapsing disorder of the gastrointestinal tract, which has not been completely cured in patients so far. Valeriana jatamansi Chinese medicine used clinically treat "diarrhea," closely related UC. This study was elucidate therapeutic effects V. extract (VJE) on dextran sodium sulfate (DSS)-induced UC mice its underlying mechanism. In this work, VJE effectively ameliorates symptoms histopathological...
Abstract Objective The primary object of this study is to analyze chromosomal abnormalities in miscarriages detected by copy number variants sequencing (CNV-Seq), establish potential pathways or genes related miscarriages, and provide guidance for birth health the following pregnancies. Methods This enrolled 580 miscarriage cases with paired clinical information detection results analyzed CNV-Seq. Further bioinformatic analyses were performed on validated pathogenic CNVs (pCNVs). Results Of...
A series of 3′,4′,5′-trimethoxy flavonoids with benzimidazole linked by different chain alkanes have been designed and synthesized.
Atherosclerosis, a major contributor to cardiovascular disease, remains significant health concern worldwide. While previous research has shown that acid-sensing ion channel 1 (ASIC1) impedes macrophage cholesterol efflux, its precise role in atherogenesis and the underlying mechanisms have remained elusive.
The discovery of a novel potent type II ABL/c-KIT dual kinase inhibitor compound 34 (CHMFL-ABL/KIT-155), which utilized hydrogen bond formed by NH on the backbone and carbonyl oxygen as unique hinge binding, is described. potently inhibited purified ABL (IC50: 46 nM) c-KIT 75 in biochemical assays displayed high selectivity (S Score (1) = 0.03) at concentration 1 μM among 468 kinases/mutants KINOMEscan assay. It exhibited strong antiproliferative activities against BCR-ABL/c-KIT driven...
A series of flavonoid salicylate derivatives containing trimethoxybenzene and a chrysin were synthesized for use as anti-tumor agents, evaluated antiproliferative activity.
// Fenggen Yan 1 , Fen Yang Rui Wang Xiao Jun Yao Liping Bai Xing Zeng 2 JiaJun Huang Vincent Kam Wai Wong Christopher Kei Lam Hua Zhou Xiaohui Su Juan Liu Ting Li Liang State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute for Applied Medicine and Health, Macau University Science Technology, Macau, China Guangdong Provincial Academy Medical Sciences, Guangzhou, Correspondence to: Liu, email: lliu@must.edu.mo Li, tli@must.edu.mo Keywords: isoliquiritigenin, IKKβ,...
Posterior malleolar fractures have been reported to occur in < 40% of ankle fractures.To reveal the recurrent patterns and characteristics posterior by creating fracture maps through use computed tomography mapping.A consecutive series was used create three-dimensional reconstruction images, which were oriented superimposed fit an model template both aligning specific biolandmarks reducing reconstructed fragments. Fracture lines found traced order generate map.This study involved 112...
A series of tryptamine salicylic acid derivatives were synthesized and their antiproliferative activity against MGC-803, MCF-7, HepG2, A549 HeLa cell lines was evaluated. The structure-activity relationship (SAR) study revealed that different substitutions the C5 C3'-C5' positions have certain effects on anti-proliferation activity. growth assay N-[2-(5-bromo-1H-indol-3-yl)-ethyl]-2-hydroxy-3-methyl-benzamide (E20) showed most potent broad-spectrum anticancer inhibition all evaluated, only...
According to the combination principle, target compounds were designed; compound<bold>10v</bold>might be a promising multiple anti-tumor agent candidate.
Phenotypes of some rare genetic diseases are atypical and it is a challenge for pediatric intensive care units (PICUs) to diagnose manage such patients in an emergency. In this study, we investigated 58 PICU (39 deceased 19 surviving) critical ill status or died shortly without clear etiology. Whole exome sequencing was performed 103 DNA samples from their families. Disease-causing single-nucleotide variants (SNVs) copy number (CNVs) were identified do genotype-phenotypes analysis. total, 27...
Abstract Background The COVID-19 pandemic has exerted an unprecedented and universal impact on global health system, resulting in noticeable challenges traditional chronic disease care, of which diabetes was reported to be most influenced by the reduction healthcare resources pandemic. China world’s largest population, current management is unsatisfactory, particularly rural areas. Studies developed countries have demonstrated that physician-pharmacist collaborative clinics are efficient...
Background Birthweight have profound impacts on health status throughout lifetime, however, the relationship between maternal ferritin level in pregnancy and birthweight of newborn remains controversial. Objective This retrospective cohort research was to analyze association levels during with outcomes, primarily for low (LBW) small gestational age (SGA). Methods Newborns weighing lower than 2,500 grams were defined as LBW. SGA is 10 th percentile distribution newborns' same age....
Bcr-Abl plays an important role in the pathogenesis and development of chronic myeloid leukemia (CML). But is prone to mutation, so it increases difficulty clinical treatment. Therefore, crucial design a new class broad-spectrum inhibitors. Herein, forty novel thiazolamide-benzamide derivatives were synthesized evaluated their inhibitory activities. The newly compounds characterized by using spectrum data (1H NMR, APCI-MS IR) elemental analysis. protein kinase results indicated that eight...
5-Arylbenzofuran neolignans, a newfound class of natural products, were semi-synthesized, and series derivatives designed, synthesized evaluated for cytotoxicity.