A5004228802- Advanced Photocatalysis Techniques
- TiO2 Photocatalysis and Solar Cells
- Advanced Nanomaterials in Catalysis
- Electrocatalysts for Energy Conversion
- Receptor Mechanisms and Signaling
- Nanoplatforms for cancer theranostics
- Mycotoxins in Agriculture and Food
- melanin and skin pigmentation
- Ovarian function and disorders
- Phytochemicals and Antioxidant Activities
- Perovskite Materials and Applications
- Pomegranate: compositions and health benefits
- Quantum Dots Synthesis And Properties
- Advanced biosensing and bioanalysis techniques
- Plant Molecular Biology Research
- Covalent Organic Framework Applications
- Kruppel-like factors research
- Acute Myeloid Leukemia Research
- Advanced Glycation End Products research
- MicroRNA in disease regulation
- Per- and polyfluoroalkyl substances research
- Ga2O3 and related materials
- Genomics, phytochemicals, and oxidative stress
- Cancer-related molecular mechanisms research
- Hedgehog Signaling Pathway Studies
Chinese Academy of Agricultural Sciences
2023-2025
Novel (United States)
2025
Institute of Vegetables and Flowers
2023-2025
Harbin Medical University
2013-2025
Wenzhou Medical University
2025
Zhejiang Lab
2025
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2025
Shandong University of Traditional Chinese Medicine
2024-2025
Beijing University of Chinese Medicine
2023-2025
First Affiliated Hospital of Harbin Medical University
2021-2025
Nanodrugs are becoming increasingly important in the treatment of bacterial infection, but their low penetration ability to biofilm is still main challenge hindering therapeutic effect. Herein, nitric oxide (NO)-driven nanomotor based on L-arginine (L-Arg) and gold nanoparticles (AuNPs) loaded dendritic mesoporous silica (AG-DMSNs) fabricated. AG-DMSNs have characteristics cascade catalytic reaction, where glucose first catalyzed by asymmetrically distributed AuNPs with oxidase (GOx)- mimic...
Chromatin topology can impact gene regulation, but how evolutionary divergence in chromatin has shaped regulatory landscapes for distinctive human traits remains poorly understood. CTCF sites determine by forming domains and loops. Here, we show CTCF-mediated at the domain loop scales during primate evolution, elucidating distinct mechanisms shaping landscapes. Human-specific divergent lead to a broad rewiring of transcriptional Divergent loops concord with species-specific enhancer...
There is increasing global concern regarding the health impacts of perfluoroalkyl and polyfluoroalkyl substances (PFAS), which are emerging environmental endocrine disruptors. Results from previous epidemiological studies on associations between PFAS exposure sex hormone levels inconsistent.We examined serum compounds (PFDeA, PFHxS, PFNA, PFOA, PFOS) hormones, including total testosterone (TT), free (FT), estrogen (E), binding globulin (SHBG).After adjusting for potential confounders, PFDeA,...
Zearalenone (ZEA) is a nonsteroidal estrogenic mycotoxin, which mainly contaminates grains and has estrogen-like effects on the reproductive system. Betulinic acid (BA), natural lupane-type pentacyclic triterpene, anti-oxidative anti-inflammatory properties. This study aimed to investigate whether BA alleviates ZEA-induced testicular damage explore possible mechanism. Here, ameliorated by mitigating disordered arrangement of seminiferous tubules, exfoliation lumen cells, increase cell...
Although dasatinib is effective in most imatinib mesylate (IMT)-resistant chronic myeloid leukemia (CML) patients, the underlying mechanism of its effectiveness eliminating imatinib-resistant cells only partially understood. This study investigated effects on signaling mechanisms driving-resistance CML cell line K562 (K562R(IMT)). Compared with control cells, exsomal release, phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/ mammalian target rapamycin (mTOR) and autophagic activity...
T-2 toxin, the most toxic of trichothecenes, is widely found in grains and feeds, its intake poses serious risks to health humans animals. An important cytotoxicity mechanism toxin production excess free radicals, which turn leads oxidative stress. Betulinic acid (BA) has many biological activities, including antioxidant activity, a plant-derived pentacyclic triterpenoid. The protective effects mechanisms BA blocking stress caused by acute exposure thymus mice was studied. pretreatment...
Abstract Regulation of angiogenesis is a great challenge for effective anticancer therapy. Generally, anti‐angiogenic therapies are focused on inhibition inducers involved in pro‐angiogenic communication pathways. Despite the potential therapy, engineering efficient agents (AIAs) still formidable challenge, since most limited due to cancer recurrence via compensatory expression different angiogenic mediators. Herein, we present new strategy near‐infrared‐II (NIR‐II) responsive hydrogel AIAs,...
We investigated the effects of a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (statin) on inhibitory an angiotensin II type-1 receptor (AT 1 ) blocker atherosclerosis and explored cellular mechanisms. gave apolipoprotein E null mice high-cholesterol diet for 10 weeks measured atherosclerotic plaque area lipid deposition. Neither mg/kg per day valsartan nor 3 fluvastatin had any effect blood pressure or cholesterol concentration; however, both drugs decreased deposition after...
Betulinic acid (BA), a pentacyclic triterpenoid, has been associated with several biological effects, such as antioxidant, anti-inflammatory and antiviral activities. Previous studies have demonstrated that BA the ability to alleviate intestinal mucosal damage, however, potential mechanism effect not reported. This study aimed investigate possible protective of against cyclophosphamide (CYP)-induced damage. Here, we found pretreatment prevented barrier dysfuction from CYP-challenged mice by...
Cold-catalytic nanomedicine and the concept of cold-catalytic immunotherapy are explored with black phosphorus as a model cold catalyst.
To determine the safety and efficacy of canagliflozin in comparison to metformin polycystic ovary syndrome (PCOS) patients with insulin resistance (IR).A single-centre, prospective, randomized open-label (ratio 1:1) noninferiority trial was conducted at Department Endocrinology, Shanghai Tenth People's Hospital, between July 2019 April 2021. Women aged 18 45 years PCOS IR were enrolled randomly assigned either 100 mg (n = 33) daily or 1500 2000 35) for 12 weeks. The primary outcome changes...
Herein, a novel Bi(OH)3 photocatalyst was successfully synthesized. Benefiting from the suitable band positions, abundant alkaline groups and oxygen vacancies, as-prepared semiconductor exhibits efficient activity in both photocatalytic CO2 reduction with CO production rate of 36 μmol g-1 h-1 phenol decomposition 92.7% degradation 180 min.
Particulate matter (PM) has always received widespread attention, PM2.5 pollution is associated with many adverse effects, including cardiovascular, respiratory and metabolic diseases mood disorders. However, the underlying mechanisms are not yet clear. In this study, small animal whole body inhalation exposure system collected real-time in real environment, which can truly reflect presence status of atmospheric environment. This study investigated depressive like behavior mice exposed to...
Interleukins as immunomodulators are promising therapeutic agents for cancer therapy. Previous studies showed that there was an improved antitumor immunity in tumor-bearing mice using recombinant Newcastle disease virus carrying interleukin-2. Interleukin-12 is a cytokine too. So we investigated and compared the effect of genetically engineered strains expressing both interleukin-12 and/or interleukin-2 (rClone30–interleukin-2, rClone30–interleukin-12, rClone30–interleukin-12–interleukin-2)....