A5046295095- Retinal Imaging and Analysis
- Retinal Diseases and Treatments
- RNA modifications and cancer
- Glaucoma and retinal disorders
- Protein Kinase Regulation and GTPase Signaling
- Esophageal Cancer Research and Treatment
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Trace Elements in Health
- Cancer-related Molecular Pathways
- Cell death mechanisms and regulation
- Innovations in Medical Education
- Inflammatory Bowel Disease
- Amyotrophic Lateral Sclerosis Research
- Cancer Research and Treatments
- Chronic Kidney Disease and Diabetes
- Neurological Disease Mechanisms and Treatments
- Adenosine and Purinergic Signaling
- Protein Tyrosine Phosphatases
- Renal and Vascular Pathologies
- Cancer Cells and Metastasis
- FOXO transcription factor regulation
- Medical Education and Admissions
Shantou University
2017-2024
Shantou University Medical College
2017-2024
Guangdong Academy of Medical Sciences
2022-2024
Southern Medical University
2023-2024
Guangdong Provincial People's Hospital
2022-2024
Abstract Background Seeking online health information (OHI) has become a common practice globally. The seekers could face risks if they are not proficient in OHI literacy. OHI-seeking behaviors and skills of Chinese college students, the largest proportion students world, understudied. This study was aimed to describe Guangdong, China. Methods College Guangdong province with experience were invited via WeChat, QQ, Sina Weibo using QR code posters flyers for participation this anonymized...
Observational studies have indicated associations between inflammatory bowel disease (IBD) and neurodegenerative diseases, including Parkinson's (PD).To evaluate the causal of IBD with PD other selected disorders using updated data.Bidirectional two-sample Mendelian randomization genome-wide association summary statistics PD.We found a lack evidence for on (odds ratio [OR], 1.014; 95% confidence interval [CI], 0.967-1.063; P = 0.573). Reverse analysis also no effect (OR, 0.978; CI,...
Development of chemoresistance remains a major challenge in treating esophageal squamous cell carcinoma (ESCC) patients despite treatment advances. However, the role RAC1 ESCC and underlying mechanisms remain largely unknown. In this study, we found that higher levels expression were associated with poorer prognosis patients. Enhanced increased proliferation, migration, vitro. Combination therapy using inhibitor EHop-016 cisplatin significantly promoted viability inhibition, G2/M phase cycle...
Objective To examine the risk factors for falls in elderly patients with visual impairment (VI) and assess predictive performance of these factors. Methods Between January 2019 March 2021, a total 251 aged 65–92 years VI were enrolled then prospectively followed up 12 months to evaluate outcomes accidental via telephone interviews. Information demographics lifestyle, gait balance deficits, ophthalmic systemic conditions collected during baseline visits. Forward stepwise multivariable...
Background Considered as the representatives of neurodegenerative diseases, Alzheimer’s disease (AD) and glaucoma are complex progressive neuropathies affected by both genetic environmental risk factors cause irreversible damages. Current research indicates that there common features between AD in terms epidemiology pathophysiology. However, understandings explanations their comorbidity potential overlaps still limited insufficient. Method Genetic pleiotropy analysis was performed using...
Published observational studies have revealed the connection between neurodegenerative disorders and inflammatory bowel disease (IBD), whereas causal association remains largely unclear. Our study aims to assess causality identify shared genetic architecture IBD. Two-sample Mendelian randomization analyses were performed IBD (amyotrophic lateral sclerosis [ALS], Alzheimer's [AD], Parkinson's [PD], multiple [MS]). Shared loci, functional interpretation, transcriptomic profiles further...
The aim of this study was to investigate the effects miR-940 and Toll-like receptor 4/Nuclear Factor κB (TLR4/NF-κB) pathways on inflammatory responses spinal cord injury (SCI).This first established a model in mice. grip force measurement used detect recovery forelimb, left forelimb right SCI quantitative Real Time-Polymerase Chain Reaction (qRT-PCR) expression macrophage TLR4 In addition, protein levels inducible nitric oxide synthase (iNOS) mice were detected by Western blot. MiR-940...
Abstract Objective Diabetic macular edema (DME) is the leading cause of visual impairment in patients with diabetes mellitus (DM). The goal early detection has not yet achieved due to a lack fast and convenient methods. Therefore, we aim develop validate prediction model identify DME type 2 (T2DM) using easily accessible systemic variables, which can be applied an ophthalmologist-independent scenario. Methods In this four-center, observational study, total 1994 T2DM who underwent routine...
Rac1 is a small signaling protein, which belongs to the Rho subfamily of Ras superfamily. It activated by binding GTP and inactivated exchanging GDP for GTP. The ability nucleotide exchange depends on guanine factors (GEFs) family proteins. T-lymphoma invasion metastasis factor 1 (Tiam1) member GEFs. participates in multiple pathways regulates various cellular events interacting with Particularly, it involved development progression kinds tumors. In this paper, we have studied detailed...
The Strength of Motivation for Medical School-Revised (SMMS-R) questionnaire measures students' motivation studying medicine. It includes three subscales: 'willingness to sacrifice', 'readiness start', and 'persistence'. Measurement invariance is a prerequisite group comparisons. objectives this study were verify the factorial structure SMMS-R investigate it's measurement invariance. A total 989 medical students approached, 930 cases kept data analysis. Factorial tested using single multiple...
Abstract Motivation Many ophthalmic disease biomarkers have been identified through comprehensive multiomics profiling, and hold significant potential in advancing the diagnosis, prognosis, management of diseases. Meanwhile, eye itself serves as a natural biomarker for several systemic diseases including neurological, renal, cardiovascular systems. We aimed to collect standardize this information construct database (EBD) provide ophthalmologists with platform search, analyze, download these...
Conventionally, Rho guanine nucleotide exchange factors (GEFs) are known activators of guanosine triphosphatases (GTPases) that promote tumorigenesis. However, the role GEFs in non-small cell lung cancer (NSCLC) remains largely unknown. Through screening 81 for their expression profiles and correlations with survival, four them were identified strong significance predicting prognosis NSCLC patients. The GEFs, namely ABR, PREX1, DOCK2 DOCK4, downregulated tissues compared to normal tissues....
Presently, a variety of policies and measures has implemented to enhance the scientific research innovation ability medical students, but in process practice, there are many problems, such as they lack independent topic selection ability, weak skills, autonomous learning results simple ineffective, limited teacher guidance time so on. This paper attempted build an effective model for promotion students' order establish efficacy evaluation "Medical Innovative Scientific Research Program."...
BACKGROUND: Esophageal squamous cell carcinoma (ESCC) has poor prognosis mainly due to the difficulty of making early diagnosis. Therefore, novel biomarkers are critically needed. OBJECTIVE: We aimed investigate diagnostic value serum interleukin-8 (IL-8) in ESCC. METHODS: Data mining TCGA was used analyze expression level IL-8 mRNA esophageal carcinoma. Serum levels were measured 103 ESCC patients and 86 normal controls by ELISA. Receiver operating characteristic (ROC) curve evaluate its...
Background: Esophagogastric junction adenocarcinoma (EJA) is one of the most common malignant tumors digestive tract with high mortality worldwide. Given a lack early diagnosis biomarkers, prognosis EJA poor. Non-invasive biomarkers for early-stage are urgently required. Objective: We aimed at evaluating diagnostic value serum interleukin-8 (IL-8) level in patients. Methods: The IL-8 mRNA expression data were analyzed based on stomach cardia samples Cancer Genome Atlas (TCGA) database....
ABSTRACT Background Chronic kidney disease (CKD) increases the risk of cardiovascular (CVD) and is more prevalent in older adults. Retinal age gap, a biomarker aging based on fundus images, has been previously developed validated. This study aimed to investigate association retinal gap with CKD subsequent CVD complications. Methods A deep learning model was trained predict using 19 200 images 11 052 participants without any medical history at baseline. calculated as predicted minus...
Abstract Objective Published observational studies have revealed the connection between inflammatory bowel disease (IBD) and neurodegenerative disorders, whereas causality remains largely unclear. Our study aims to assess identify shared genetic architecture IBD disorders. Design A series of two-sample Mendelian randomization analyses were performed disorders (amyotrophic lateral sclerosis [ALS], Alzheimer’s [AD], Parkinson’s [PD], multiple [MS]). Shared loci functional interpretation...
Abstract Esophageal squamous cell carcinoma (ESCC) is a highly aggressive malignancy with poor prognosis. Despite treatment advances, development of chemo-resistance remains major challenge in treating ESCC patients. Ras-related C3 botulinum toxin substrate 1 (RAC1) essential regulating cancer progression. However, its role and the underlying mechanisms are still unknown. In this study, we found that higher levels RAC1 expression were associated poorer disease-free survival (p=0.014) overall...
Esophageal squamous cell carcinoma (ESCC) is a highly aggressive malignancy with poor prognosis. Despite treatment advances, development of chemo-resistance remains major challenge in treating ESCC patients. Ras-related C3 botulinum toxin substrate 1 (RAC1) essential regulating cancer progression. However, its role and the underlying mechanisms are still unknown. In this study, we found that higher levels RAC1 expression were associated poorer disease-free survival (p=0.014) overall...
Abstract Background: Conventionally, RHO GEFs are known as activators for GTPases which promote tumorigenesis. However, the role of in non-small cell lung cancer (NSCLC) remains largely unknown. Methods: A comprehensive bioinformatics analysis protein structure, transcriptional expression, survival, methylation, mutation and gene-set enrichment data was performed using multiple databases. Results: Through screening 81 their expression profiles correlations with four them identified strong...