A5101858479- 3D Printing in Biomedical Research
- Neuroscience and Neural Engineering
- Cancer Cells and Metastasis
- Cellular Mechanics and Interactions
- Photoreceptor and optogenetics research
- Microfluidic and Bio-sensing Technologies
- Nanofabrication and Lithography Techniques
- Advanced Glycation End Products research
- Autophagy in Disease and Therapy
- Plant Pathogens and Fungal Diseases
- Pharmacological Effects of Natural Compounds
- Sirtuins and Resveratrol in Medicine
- Bioactive Compounds and Antitumor Agents
- Angiogenesis and VEGF in Cancer
- Mitochondrial Function and Pathology
- Retinal Diseases and Treatments
- Mycorrhizal Fungi and Plant Interactions
- Industrial Technology and Control Systems
- Nematode management and characterization studies
- Carbon Dioxide Capture Technologies
- Acute Kidney Injury Research
- Diet and metabolism studies
- Barrier Structure and Function Studies
- Eicosanoids and Hypertension Pharmacology
- Morinda citrifolia extract uses
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2025
Guang’anmen Hospital
2022-2025
Army Medical University
2025
Xinqiao Hospital
2025
City University of Hong Kong
2024
Cornell University
2013-2024
Jinan University
2023
Guangdong Academy of Medical Sciences
2022
Guangdong Provincial People's Hospital
2022
China Academy of Chinese Medical Sciences
2022
Abstract We investigated the mechanism by which quercetin preserves mitochondrial quality control (MQC) in cardiomyocytes subjected to ischemia–reperfusion stress. An enzyme‐linked immunosorbent assay was employed vivo experiments assess myocardial injury markers, measure transcript levels of SIRT5/DNAPK‐cs/MLKL during various time intervals ischemia–reperfusion, and observe structural changes using transmission electron microscopy. In vitro investigations, adenovirus transfection establish...
In neural interface platforms, cultures are often carried out on a flat, open, rigid, and opaque substrate, posing challenges to reflecting the native microenvironment of brain precise engagement with neurons. Here we present neuron cell culturing platform that consists arrays ordered microtubes (2.7-4.4 μm in diameter), formed by strain-induced self-rolled-up nanomembrane (s-RUM) technology using ultrathin (<40 nm) silicon nitride (SiNx) film transparent substrates. These demonstrated...
Purpose To compare ablation zones created with equal amounts of 2.45 GHz microwave and 480 kHz radiofrequency (RF) energy in ex vivo liver lung. Methods A total 38 ablations were performed lung for 10 min each. Nineteen RF (nine liver, ten lung) a system (200 W max, impedance‐based pulsing) cooled electrode while measuring the average power applied. then using triaxial antenna to deliver at same level as experiments. Ablation sectioned measured minimum, maximum mean diameters, circularity....
Cell movement is highly sensitive to stimuli from the extracellular matrix and media. Receptors on plasma membrane in cells can activate signal transduction pathways that change mechanical behavior of a cell by reorganizing motion-related organelles. Cancer their migration mechanisms response different environments more robustly than noncancer cells. Therefore, therapeutic approaches immobilize cancer via inhibition related rely better understanding mechanisms. In recent years, engineers...
In many neural culture studies, neurite migration on a flat, open surface does not reflect the three-dimensional (3D) microenvironment in vivo. With that mind, we fabricated arrays of semiconductor tubes using strained silicon (Si) and germanium (Ge) nanomembranes employed them as cell substrate for primary cortical neurons. Our experiments show SiGe tube fabrication process are biologically viable neuron cells. We also observe neurons attracted by topography, even absence adhesion factors,...
Malignant tumors are often associated with an elevated fluid pressure due to the abnormal growth of vascular vessels, and thus increased interstitial flow out tumors. Recent in vitro works revealed that flows critically regulated tumor cell migration within a three dimensional biomatrix, breast cancer behavior depended sensitively on seeding density, chemokine availability rates. In this paper, we focus role modulating heterogeneity motility phenotype biomatrix. Using newly developed...
Abstract Tumor invasion within the interstitial space is critically regulated by force balance between cell-extracellular matrix (ECM) and cell-cell interactions. Interstitial flows (IFs) are present in both healthy diseased tissues. However, roles of IFs modulating cell subsequently tumor understudied. In this article, we develop a microfluidic model which spheroids embedded 3D collagen matrices with well-defined IFs. Using co-cultured (1:1 mixture metastatic non-tumorigenic epithelial...
Tumor cell invasion, whether penetrating through the extracellular matrix (ECM) or crossing a vascular endothelium, is critical step in cancer metastatic cascade. Along way from primary tumor to distant site, cells interact actively with microenvironment either via biomechanical (e. g. ECM stiffness) biochemical (e.g. secreted cytokines) signals. Increasingly, it recognized that (TME) player invasion. A main challenge for mechanistic understanding of cell-TME interactions comes complexity...
A Myriad of biotic and abiotic factors inevitably affects the growth production tobacco (Nicotiana tabacum L.), which is a model crop sought-after worldwide for its foliage. Among various impacts level disease severity poses on plants, influence dynamics phyllospheric microbial diversity utmost importance. In China, recurring reports phyto-pathogen, Didymella segeticola, causal agent leaf spot, accentuate need in-depth investigation. Here, high-throughput sequencing technique, IonS5TMXL was...
Thiol−ene photopolymerization was used in the synthesis of elastomeric polyanhydrides. Side reactions involving addition thiol to anhydride were observed but take place at a much slower rate than photoinitiated thiol−ene polymerization. The thermomechanical properties, including glass transition temperature (Tg) as well tensile and compressive modulus, cross-linked material studied using dynamic mechanical analysis. Tg values ranged from −15 approximately −50 °C dependent on degree...
Journal Article Glycation of collagen matrices promotes breast tumor cell invasion Get access Young Joon Suh, Suh Department Biological and Environmental Engineering, Cornell University, Ithaca, NY, USA https://orcid.org/0000-0002-8281-3042 Search for other works by this author on: Oxford Academic Google Scholar Matthew S Hall, Hall Yu Ling Huang, Huang So Youn Moon, Moon Wei Song, Song Minglin Ma, Ma Lawrence J Bonassar, Bonassar Meinig School Biomedical Jeffrey E Segall, Segall Anatomy...
Background Considered as the representatives of neurodegenerative diseases, Alzheimer’s disease (AD) and glaucoma are complex progressive neuropathies affected by both genetic environmental risk factors cause irreversible damages. Current research indicates that there common features between AD in terms epidemiology pathophysiology. However, understandings explanations their comorbidity potential overlaps still limited insufficient. Method Genetic pleiotropy analysis was performed using...
Two new anthraquinones, 1,6-dihydroxy-5-methoxy-2-methoxymethylanthraquinone (1) and 1,5,7-trihydroxy-6-methoxy-2-methoxymethylanthraquinone (2), one lignan isoamericanoic acid A (3) were isolated from the fruits of Morinda citrifolia along with 11 known compounds scopoletin, luteolin, americanin A, D, 3,3′-bisdemethylpinoresinol, p-cresol, p-hydroxybenzoic acid, p-hydroxybenzaldehyde, 4-hydroxy-3-methoxybenzaldehyde, 4-hydroxy-3-methoxycinnamaldehyde, 2,5-dihydroxy-4-methoxybenzaldehyde....
Adhesive micro-lines of various sub-cellular geometries were created using a non-traditional micro stamping technique. This technique employed the use commercially available diffraction gratings as molds for stamps, method which is quick and inexpensive, could easily be adopted patterning tool in variety research efforts. The atypical saw-tooth profile stamps enabled unique degree control flexibility over patterned line gap widths. Cortical neurons cultured on poly-lysine PDMS exhibit...
The traditional Chinese medicine Yunnan Baiyao (YNB) has been reported to possess anti‑inflammatory properties, however its mechanism of action remains unclear. It was previously that YNB ameliorated depression arachidonic acid (AA) levels in a rat model collagen-induced arthritis. In the current study, capacity ameliorate inflammation compared carrageenan‑induced and AA‑induced acute paw with celecoxib mizolastine, respectively (n=24 per group). affect phospholipase A2 (PLA2)/AA pathway...
Tumor invasion, the process by which tumor cells break away from their primary and gain access to vascular systems, is an important step in cancer metastasis. Most current 3D invasion assays consisted of single embedded within extracellular matrix (ECM). These taught us much what we know today on how key biophysical (e.g. ECM stiffness) biochemical cytokine gradients) parameters microenvironment guided regulated invasion. One limitation cell assay was that it did not account for cell-cell...
We report a kinetics study on hen egg white lysozyme's (HEWL) inhibitory effect mushroom tyrosinase catalysis of 3-(3,4-dihydroxyphenyl)-L-alanine (L-DOPA) or L-tyrosine. For the first time, we demonstrate HEWL as robust inhibitor against in both substrates. The pattern matches mixed (mostly non-competitive) partial inhibition. Ki and ID50 value are more than 20-fold lower that kojic acid, well-known chemical tyrosinase. Ki, alpha beta value, almost identical experiments (L-DOPA L-tyrosine...
In the last 40 years, United States invested over 200 billion dollars on cancer research, resulting in only a 5% decrease death rate. A major obstacle for improving patient outcomes is poor understanding of mechanisms underlying cellular migration associated with aggressive cell invasion, metastasis and therapeutic resistance1. Glioblastoma Multiforme (GBM), most prevalent primary malignant adult brain tumor2, exemplifies this difficulty. Despite standard surgery, radiation chemotherapies,...
Neurons are often cultured in vitro on a flat, open, and rigid substrate, platform that does not reflect well the native microenvironment of brain. To address this concern, we have developed culturing containing arrays microchannels, formed crystalline-silicon nanomembrane (NM) resting polydimethylsiloxane; will additionally enable active sensing stimulation at local scale, via devices fabricated silicon. The mechanical properties composite Si/compliant substrate nanomaterial approximate...