A5044701800- Extracellular vesicles in disease
- Cancer Cells and Metastasis
- Immune cells in cancer
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Angiogenesis and VEGF in Cancer
- Glioma Diagnosis and Treatment
- Mesenchymal stem cell research
- Heat shock proteins research
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Cytokine Signaling Pathways and Interactions
- Hematopoietic Stem Cell Transplantation
- Neuroblastoma Research and Treatments
- Endoplasmic Reticulum Stress and Disease
- Cancer Research and Treatments
- Cell Adhesion Molecules Research
- Caveolin-1 and cellular processes
- RNA Interference and Gene Delivery
- Circular RNAs in diseases
- Immune Cell Function and Interaction
- Lymphatic System and Diseases
- Chemokine receptors and signaling
Children's Cancer and Blood Foundation
2016-2025
Cornell University
2016-2025
Weill Cornell Medicine
2016-2025
Memorial Sloan Kettering Cancer Center
2012-2024
Universidade Nova de Lisboa
2016
Neurological Surgery
2013
National Eye Institute
2013
University of California, San Francisco
2012
University of California, Los Angeles
2011
Champalimaud Foundation
2011
About 50% of cancer patients receive radiation therapy. Here we investigated the hypothesis that tumor response to is determined not only by cell phenotype but also microvascular sensitivity. MCA/129 fibrosarcomas and B16F1 melanomas grown in apoptosis-resistant acid sphingomyelinase (asmase)-deficient or Bax-deficient mice displayed markedly reduced baseline endothelial apoptosis grew 200 400% faster than tumors on wild-type microvasculature. Thus, a homeostatic factor regulating...
Colon cancer stem cells are believed to originate from a rare population of putative CD133+ intestinal cells. Recent publications suggest that small subset colon expresses CD133, and only these capable tumor initiation. However, the precise contribution tumor-initiating in mediating metastasis remains unknown. Therefore, temporally spatially track expression CD133 adult mice during tumorigenesis, we generated knockin lacZ reporter mouse (CD133lacZ/+), which is driven by endogenous promoters....
Tyrosine kinase receptors for angiogenic factors vascular endothelial growth factor (VEGF) and angiopoietin-1 (Ang-1) are expressed not only by cells but also subsets of hematopoietic stem (HSCs). To further define their role in the regulation postnatal hematopoiesis vasculogenesis, VEGF Ang-1 plasma levels were elevated injecting recombinant protein or adenoviral vectors expressing soluble VEGF165, matrix-bound VEGF189, into mice. induced a rapid mobilization HSCs receptor (VEGFR)2+...
Significance Increasing evidence suggests that extracellular vesicles (EVs) can transfer genetic material to recipient cells. However, the mechanism and role of this phenomenon are largely unknown. Here we have made a remarkable discovery: EVs harbor full mitochondrial genome. These in turn their mtDNA cells with impaired metabolism, leading restoration metabolic activity. We determined hormonal therapy induces oxidative phosphorylation-deficient breast cancer cells, which be rescued via...