A5010210504- Neuroblastoma Research and Treatments
- Childhood Cancer Survivors' Quality of Life
- Extracellular vesicles in disease
- Sarcoma Diagnosis and Treatment
- Genetic factors in colorectal cancer
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Bioinformatics and Genomic Networks
- Nausea and vomiting management
- Immunotherapy and Immune Responses
- Fibroblast Growth Factor Research
- Fungal Infections and Studies
- Neurofibromatosis and Schwannoma Cases
- Field-Flow Fractionation Techniques
- Ocular Oncology and Treatments
- Gene expression and cancer classification
- Vascular Tumors and Angiosarcomas
- Molecular Biology Techniques and Applications
- Neurogenetic and Muscular Disorders Research
- Adolescent and Pediatric Healthcare
- Proteoglycans and glycosaminoglycans research
- Anesthesia and Pain Management
- Muscle Physiology and Disorders
Tokyo National Hospital
2022-2024
National Cancer Center Hospital East
2021-2024
National Cancer Center
2024
Pediatric Oncology Group
2022
Memorial Sloan Kettering Cancer Center
2017-2021
Children's Cancer and Blood Foundation
2018-2020
Cornell University
2017-2020
Weill Cornell Medicine
2018-2020
Rockefeller University
1994-2010
Howard Hughes Medical Institute
2010
We have recently developed a novel method for the affinity purification of complete suite translating mRNA from genetically labeled cell populations. This permits comprehensive quantitative comparisons genes employed by each specific type. provide detailed description tools analysis data generated with this and related methodologies. An essential question that arises these is how to identify those are enriched in type relative all others. Genes relatively specifically may contribute unique...
Two cases of pediatric lung cancer (in 23-month-old and 6-year-old boys) resulting from mother-to-infant transmission uterine cervical tumors were incidentally detected during routine next-generation sequencing paired samples tumor normal tissue. Spontaneous regression some lesions in the first child slow growth mass second suggested existence alloimmune responses against transmitted tumors. Immune checkpoint inhibitor therapy with nivolumab led to a strong all remaining child. (Funded by...
Systematic protein-DNA binding studies have shown that plant basic leucine zipper (bZIP) proteins exhibit a differential specificity for ACGT motifs. Here, we show the rice transcription activator-1 (RITA-1) displays broad palindromic elements, being able to bind A-, C-, and G-box but not T-box elements. By using gel mobility shift assays with probes differing in sequences flanking hexameric core, identified high-affinity sites. Quantitative competition DNA confirmed RITA-1 these Using...
Somatic mutations are accumulated in normal human tissues with aging and exposure to carcinogens. If we can accurately count any passenger single DNA molecule, since their quantity is much larger than driver mutations, sensitively detect mutation accumulation polyclonal tissues. Duplex sequencing, which tags both strands one enables accurate of such but requires a very large number sequencing reads for each sample human-genome size. Here, reduced the genome size 1/90 using Bam HI restriction...
Abstract Background Single‐dose i.v. fosaprepitant has been approved as an alternative to 3 day oral aprepitant, a neurokinin‐1 receptor antagonist, and improves prevention of chemotherapy‐induced nausea vomiting ( CINV ). Because shown similar efficacy aprepitant in adult patients only, this study compared the safety pediatric patients. Methods Children younger than 18 years who received or manage between January 2015 March 2018 at National Cancer Center Hospital (Tokyo) were recruited...
Abstract Background The prognosis of relapsed or refractory osteosarcoma remains poor. Recent reports have stated that molecular targeting agents, including multiple tyrosine kinase inhibitors (MTKIs), are effective against adult osteosarcoma. To determine the safety and efficacy MTKI therapy in children, adolescents young adults (AYAs), we conducted a retrospective study on adverse events treatment outcomes. Methods We retrospectively reviewed medical records patients with who received at...
PURPOSE This single-center, prospective molecular profiling study characterizes genomic alterations and identifies therapeutic targets in advanced pediatric solid tumors. METHODS As part of the TOP-GEAR (Trial Onco-Panel for Gene to Estimate both Adverse events Response by cancer treatment) project at National Cancer Center (NCC), Japan, we enrolled patients with a refractory or recurrent disease during August 2016-December 2021 performed analysis matched tumors blood using originally...
Abstract Background Precision medicine has transformed cancer treatment by focusing on personalized approaches based genomic abnormalities. However, comprehensive profiling (CGP) and access to targeted therapies are limited in Japan. This study investigates the BELIEVE trial, which aims improve drug accessibility for patients with actionable genetic abnormalities through off-label administration. Methods The trial is a platform single master protocol, conducted under Clinical Trials Act...
Abstract Background Humanized 3F8‐bispecific antibody (hu3F8‐BsAb) using the IgG(L)‐scFv format (where scFv is single‐chain variable fragment), where anti‐CD3 huOKT3 fused with carboxyl end of hu3F8 light chain, has potent antitumor cytotoxicity against GD2(+) tumors. To overcome insufficient number and function T cells in cancer patients, they can be rejuvenated expanded ex vivo before arming hu3F8‐BsAb for adoptive transfer, potentially reducing toxic side effects from direct BsAb...
Compared to Europe and the United States, where development of pediatric oncology drugs is mandated by law, Japan hosts fewer clinical trials. This can lead a significant drug lag, especially in case treatments for solid tumors. Notably, regulatory authorities government have initiated discussions on strategies mitigate Japan's lag problem oncology. Over past decade, we actively sought opportunities participate international collaborative trials through involvement ACCELERATE its predecessor...
Background: Although conservative treatment has been used for unilateral retinoblastoma, enucleation is still the mainstay of ICRB D–E group. In Japan, performed to preserve eyes patients with retinoblastoma including group D–E. We analyzed data treated at our institution aim assessing if therapy in would worsen survival outcomes and it also enable preservation visual acuity. Procedure: retrospectively reviewed medical records from January 1, 2006, December 31, 2015. Survival rates,...
Pneumothorax and tumor-bronchial fistula are rare complications of pulmonary metastasis osteosarcoma.We herein report the cases 3 pediatric adolescent patients who developed pneumothorax or during treatment osteosarcoma with chemotherapeutics antiangiogenic agents. Two pneumothorax, other patient fistula. All finally underwent surgery to treat their complications.Although it is not a curative surgery, for acceptable. The operative procedure should be considered on basis predicted prognosis patient.
Abstract Among pediatric cancers, sarcomas, especially those with large tumor burdens and metastatic disease, often result in poor outcome. Thus, new treatments are urgently needed to inhibit progression, prevent metastasis, improve overall survival. To understand the mechanisms driving sarcoma we employed two mouse fibrosarcoma cell lines that display different growth phenotypes when transplanted into syngeneic immune competent mice. Progressor fibrosarcomas evade detection by system...