A5086685397- Acute Lymphoblastic Leukemia research
- Peripheral Artery Disease Management
- Aortic Disease and Treatment Approaches
- Childhood Cancer Survivors' Quality of Life
- Aortic aneurysm repair treatments
- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac and Coronary Surgery Techniques
- Cardiac Valve Diseases and Treatments
- Venous Thromboembolism Diagnosis and Management
- Angiogenesis and VEGF in Cancer
- Infectious Aortic and Vascular Conditions
- Cardiac Ischemia and Reperfusion
- Cerebrovascular and Carotid Artery Diseases
- Chronic Myeloid Leukemia Treatments
- Kawasaki Disease and Coronary Complications
- Psoriasis: Treatment and Pathogenesis
- Diagnosis and Treatment of Venous Diseases
- Photodynamic Therapy Research Studies
- Hemoglobin structure and function
- Infective Endocarditis Diagnosis and Management
- Coronary Artery Anomalies
- Congenital Heart Disease Studies
- Advanced MRI Techniques and Applications
Tokyo Metropolitan Children's Medical Center
2014-2023
Princess Máxima Center
2022-2023
Tokyo National Hospital
2021
National Cancer Center
2020
Jikei University School of Medicine
2014-2017
Social Insurance Saitama Chuo Hospital
1996-2010
Takashimadaira Chuo General Hospital
2010
Tokyo Medical University
2003-2008
Rockefeller University
1999
Midorigaoka Hospital
1997
The ischemic threshold of protein synthesis and energy state was determined 1, 6, 12 h after middle cerebral artery (MCA) occlusion in rats. Local blood flow amino acid incorporation were measured by double tracer autoradiography, local ATP content substrate-induced bioluminescence. various images evaluated at the striatal level cortex scanning with a microdensitometer 75 microns resolution. Each x digitized image pixel then converted into appropriate units either synthesis, content, or...
In the Bar mutation of Drosophila, ommatidial differentiation is known to be suppressed in anterior portion eye. Our structural analysis shows that region contains a pair homeo box genes, BarH1 and BarH2. These genes encode polypeptides similar size sequence share common domain identical except for putative trans-activator-binding sites. We also show, by mosaic immunostaining with anti-BarH1/BarH2 antibodies, BarH2 are not only specifically coexpressed but functionally required R1/R6...
Recent studies revealed that a substantial proportion of patients with high-risk B-cell precursor acute lymphoblastic leukemia (BCP-ALL) harbor fusions involving tyrosine kinase and cytokine receptors, such as ABL1, PDGFRB, JAK2 CRLF2, which are targeted by inhibitors (TKIs). In the present study, transcriptome analysis or multiplex reverse transcriptase-PCR 373 BCP-ALL without recurrent genetic abnormalities identified 29 fusions. Clinically, male predominance (male/female: 22/7), older age...
The Bar mutation B of Drosophila melanogaster and optic morphology Om(1D) ananassae result in suppression ommatidium differentiation at the anterior portion eye. Examinations was made to determine genes responsible for these mutations. Both loci were found share common a different type homeobox gene, which we call "BarH1." Polyptides encoded by D. BarH1 consist 543 604 amino acids, respectively, with homeodomains identical sequence except one acid substitution. A unique feature is that...
Background Parents of children with cancer are susceptible to psychological distress; however, many parents also report posttraumatic growth (PTG). The objective this study was explore the variables associated PTG in who were either on treatment or off treatment. Methods One hundred and nineteen (71 mothers 48 fathers) completed self-report questionnaires, including Inventory, Center for Epidemiologic Studies Depression Scale, State-Trait Anxiety Impact Event Scale-Revised. Demographic data...
Graft failure has been reported when the arterial conduit, such as internal thoracic artery (ITA) or right gastroepiploic (GEA), is grafted to a lower grade coronary stenosis. The shear stress significant factor affecting graft patency was compared between conduit and saphenous vein (SVG) after surgery.In 101 patients, 40 ITAs, 27 GEAs 34 SVGs were examined using Doppler-tipped guide wire during postoperative angiography. flow volume calculated from velocity diameter data. study grafts...
The role of allogeneic hematopoietic stem cell transplantation (HSCT) for infants with acute lymphoblastic leukemia (ALL) and KMT2A gene rearrangement (KMT2A-r) is controversial in terms both its efficacy potential late toxicities. In Japanese Pediatric Leukemia/Lymphoma Study Group trial MLL-10, by introducing intensive chemotherapy, indication HSCT was restricted to patients high-risk (HR) features only (KMT2A-r either age <180 days or presence central nervous system leukemia). Of the 56...
In order to elucidate the cause and pathology of varicose veins in lower limb, terminal valves long saphenous vein 36 patients with ten control cases have been examined by light transmission electron microscopy. Valve failure group was thought start a depression valvular commissure proceed extension this expansion space between two valves. It further that, group, reversal tortuosity valve cusps, hyperplasia collagen fibres irregularity course elastic fibre layers represented secondary...
Abstract Background Single‐dose i.v. fosaprepitant has been approved as an alternative to 3 day oral aprepitant, a neurokinin‐1 receptor antagonist, and improves prevention of chemotherapy‐induced nausea vomiting ( CINV ). Because shown similar efficacy aprepitant in adult patients only, this study compared the safety pediatric patients. Methods Children younger than 18 years who received or manage between January 2015 March 2018 at National Cancer Center Hospital (Tokyo) were recruited...
Abstract Background Precision medicine has transformed cancer treatment by focusing on personalized approaches based genomic abnormalities. However, comprehensive profiling (CGP) and access to targeted therapies are limited in Japan. This study investigates the BELIEVE trial, which aims improve drug accessibility for patients with actionable genetic abnormalities through off-label administration. Methods The trial is a platform single master protocol, conducted under Clinical Trials Act...
The prognosis of children with acute myeloid leukemia (AML) has improved incrementally over the last few decades. However, at relapse, overall survival (OS) is approximately 40–50% and even lower for patients chemo-refractory disease. Effective less toxic therapies are urgently needed these children. Pediatric Acute Leukemia (PedAL) program a strategic global initiative that aims to overcome obstacles in treating relapsed/refractory supported by Lymphoma Society collaboration Children’s...
Histopathologic and immunofluorescence findings of facial annular erythema on a 3-month-old female child, as well serological detection anti-SS-A (Ro) anti-SS-B (La) antibodies, led to the diagnosis neonatal lupus erythematosus (LE), while no sign abnormality in conducting system heart was found. During pregnancy present child her mother, with positive had history Sweet's syndrome. She treated corticosteroid, resulting gradual diminution existing complete atrioventricular block fetus. This...
Rearrangements of chromosome 8q24/MYC (8q24/MYC-r), resulting from t(8;14)(q24;q32), t(2;8)(p11;q24), or t(8;22)(q24;q11), are mainly associated with Burkitt lymphoma/leukemia (BL) and rarely observed in patients B-cell precursor acute lymphoblastic leukemia (BCP-ALL). The characteristics BCP-ALL 8q24/MYC-r poorly understood.A retrospective nationwide study data pediatric Japan was conducted to clarify the clinical biological BCP-ALL.Ten 8q24/MYC-r, including three double-hit (DHL) (two...
Abstract The effect of genetic variation on second malignant neoplasms (SMNs) remains unclear. First, we identified the pathogenic germline variants in cancer-predisposing genes among 15 children with SMNs after childhood leukemia/lymphoma using whole-exome sequencing. Because prevalence was low, focused association between and NUDT15 primary acute lymphoblastic leukemia (ALL) cases. is one 6-mercaptopurine (6-MP) metabolic genes, its are common East Asian individuals. hypomorphic higher...
Abstract Background Second malignant neoplasms (SMNs) are one of the most severe late complications after pediatric cancer treatment. However, effect genetic variation on SMNs remains unclear. In this study, we revealed germline factors that contribute to development treatment solid tumors. Methods We performed whole‐exome sequencing in 14 patients with SMNs, including three brain Results Our analysis five (35.7%) had pathogenic variants cancer‐predisposing genes (CPGs), which was...