A5026840406- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Immunodeficiency and Autoimmune Disorders
- Acute Myeloid Leukemia Research
- Glioma Diagnosis and Treatment
- Cytomegalovirus and herpesvirus research
- Lymphoma Diagnosis and Treatment
- Neutropenia and Cancer Infections
- Polyomavirus and related diseases
- Epigenetics and DNA Methylation
- Platelet Disorders and Treatments
- Neonatal Health and Biochemistry
- Blood disorders and treatments
- Pancreatic and Hepatic Oncology Research
- Sarcoma Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Chronic Lymphocytic Leukemia Research
- Neurological Complications and Syndromes
- Cancer Genomics and Diagnostics
- Neuroblastoma Research and Treatments
- Chronic Myeloid Leukemia Treatments
- Neurological Disease Mechanisms and Treatments
- Electrolyte and hormonal disorders
- Bone and Joint Diseases
- Retinoids in leukemia and cellular processes
National Center For Child Health and Development
2021-2025
Hokkaido University
2015-2025
National Institute for Japanese Language and Linguistics
2024
Jikei University Kashiwa hospital
2024
Hokkaido University Hospital
2014-2023
The University of Tokyo
2010-2023
Showa University Fujigaoka Hospital
2023
Showa University Fujigaoka Rehabilitation Hospital
2023
Showa University
2021-2023
The Japanese Data Center for Hematopoietic Cell Transplantation
2021-2022
The genetic associations of TREM2 loss-of-function variants with Alzheimer disease (AD) indicate the protective roles microglia in AD pathogenesis. Functional deficiencies disrupt microglial clustering around amyloid β (Aβ) plaques, impair their transcriptional response to Aβ, and worsen neuritic dystrophy. However, molecular mechanism underlying these phenotypes remains unclear. In this study, we investigated pathological role another risk gene, INPP5D, encoding a phosphoinositide...
Abstract Genetic alterations of Ikaros family zinc finger protein 1 ( IKZF ), point mutations in Janus kinase 2 JAK and overexpression cytokine receptor‐like factor CRLF ) were recently reported to be associated with poor outcomes pediatric B‐cell precursor BCP )‐ ALL . Herein, we conducted genetic analyses deletion, mutation exon 16, 17, 21, expression, the presence P2 RY 8‐ fusion F232C 202 ‐ patients newly diagnosed registered Japan Childhood Leukemia Study 02 protocol find out if these...
X-linked chronic granulomatous disease (X-CGD) may be associated with McLeod syndrome (MLS) as a contiguous gene deletion syndrome. MLS is characterized by the loss of XK protein along Kx antigen on red blood cell (RBC) surfaces and late-onset neurocognitive symptoms. RBCs in healthy donors express related surface; therefore, transfusion from random to patients poses risk sensitization, leading severe hemolysis. As radical treatment X-CGD hematopoietic transplantation (HCT), treating...
Abstract Aims This study aimed to examine whether microorganisms capable of degrading the artificial polyhydroxyalkanoate (PHA) copolymer poly(2-hydroxybutyrate-co-3-hydroxybutyrate) [P(2HB-co-3HB)], with random and block sequences, are present in natural environments. Previously isolated PHA-degrading soil bacteria was tested using 2HB-rich copolymers, P(2HB-ran-3HB) P(2HB)-b-P(3HB), as a major carbon source. The assimilation 2HB 3HB fractions these copolymers effect monomer sequence on...
Pancreatoblastoma is a rare pediatric pancreatic malignancy for which the molecular pathogenesis not understood. In this study, we report findings of an integrated multiomics study whole-exome and RNA sequencing as well genome-wide copy number methylation analyses ten pancreatoblastoma cases. The genome was characterized by high frequency aberrant activation Wnt signaling pathway, either via somatic mutations CTNNB1 (90%) copy-neutral loss heterozygosity (CN-LOH) APC (10%). addition,...
This study was a second multicenter trial on childhood ALL by the Japan Childhood Leukemia Study Group (JACLS) to improve outcomes in non-T ALL. Between April 2002 and March 2008, 1138 children with were enrolled JACLS ALL-02 trial. Patients stratified into three groups using age, white blood cell count, unfavorable genetic abnormalities, treatment response: standard risk (SR), high (HR), extremely (ER). Prophylactic cranial radiation therapy (PCRT) abolished except for CNS leukemia....
The molecular structure of mouse Mucin 21 (Muc21)/epiglycanin is proposed to have 98 tandem repeats 15 amino acids and three exceptional with 12 or 13 each, followed by a stem domain, transmembrane cytoplasmic tail. A cDNA Muc21 having 84 was constructed transfected using Venus vector into HEK 293T cells. fluorescent cells, which were considered express Muc21, nonadherent. This antiadhesion effect lessened when constructs smaller numbers used, suggesting that the repeat domain plays crucial...
<b><i>Objective:</i></b> Most types of intracranial germ cell tumors (IGCTs) are sensitive to chemoradiation. However, biopsy specimens usually small and thus cannot be used for obtaining an accurate pathological diagnosis. Recently, the cerebrospinal fluid (CSF) placental alkaline phosphatase (PLAP) value has been considered a new biomarker IGCTs. The present study aimed evaluate discriminatory characteristics CSF-PLAP upon diagnosis at time recurrence in patients...
The aim of this study was to elucidate risk factors for mortality after developing sepsis in pediatric patients with hematologic and malignant disorders.A total 90 (43 boys, 47 girls) various diseases who experienced between June 2006 March 2014 were enrolled. Clinical laboratory features 134 episodes observed the compared those without sepsis-related death which defined as within 14 days sepsis.Age at hospitalization, sex, type underlying disease did not differ death. Sepsis episode-based...
Hematopoietic cell transplantation (HCT) is established as a curative treatment for severe chronic granulomatous disease (CGD). However, outcomes of HCT CGD in Japan had not been precisely reported. We evaluated the outcome by means nationwide survey. A total 91 patients (86 males and 5 females) with who received between 1992 2013 was investigated. Their median age at 11 years (0-39). Sixty-four X-linked caused CYBB gene mutations, 13 autosomal recessive (7 CYBA 6 NCF2), 14 were genetically...