A5035483947- Peripheral Neuropathies and Disorders
- Immunodeficiency and Autoimmune Disorders
- Immune Cell Function and Interaction
- Systemic Lupus Erythematosus Research
- Autoimmune Bullous Skin Diseases
- Systemic Sclerosis and Related Diseases
- Monoclonal and Polyclonal Antibodies Research
- Cell Adhesion Molecules Research
- Inflammatory Myopathies and Dermatomyositis
- Hereditary Neurological Disorders
- Lymphoma Diagnosis and Treatment
- T-cell and B-cell Immunology
- Salivary Gland Disorders and Functions
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Salivary Gland Tumors Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Autoimmune Neurological Disorders and Treatments
- Chronic Lymphocytic Leukemia Research
- Atherosclerosis and Cardiovascular Diseases
- Skin Diseases and Diabetes
- Insect behavior and control techniques
- GDF15 and Related Biomarkers
- Myasthenia Gravis and Thymoma
- Inflammasome and immune disorders
Universitat Autònoma de Barcelona
2012-2024
Hospital de Sant Pau
2015-2024
Institut de Recerca Sant Pau
2024
Charles River Laboratories (United Kingdom)
2024
Sheikh Shakhbout Medical City
2023
Emirates Foundation
2023
Universitat de Barcelona
2021
Hospital Clínico Universitario de Valencia
2021
Biomedical Research Institute
2020
Muscular Dystrophy UK
2020
One year after the occurrence of first case infection by Middle East Respiratory Syndrome coronavirus (MERS-CoV) there is no clear consensus on best treatment to propose. The World Health Organization, as well several other national agencies, are still working different clinical approaches implement most relevant in MERS-CoV infection. We compared innate and adaptive immune responses two patients infected with understand underlying mechanisms involved response propose potential therapeutic...
Objectives To develop and validate a specific protocol for SARS-CoV-2 detection in breast milk matrix to determine the impact of maternal infection on presence, concentration persistence antibodies. Design patients This is prospective, multicentre longitudinal study (April–December 2020) 60 mothers with and/or who have recovered from COVID-19. A control group 13 women before pandemic were also included. Setting Seven health centres different provinces Spain. Main outcome measures Presence...
Abstract Previous studies have described the clinical, serological and pathological features of patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) antibodies directed against paranodal proteins neurofascin-155, contactin-1 (CNTN1), contactin-associated protein-1 (Caspr1), or nodal forms neurofascin. Such are useful for diagnosis potentially treatment selection. However, targeting Caspr1 only Caspr1/CNTN1 complex been reported in few CIDP. Moreover, it is unclear...
The aim of the research is to study human leukocyte antigen (HLA) class II allele frequencies in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) associated with anti-neurofascin 155 (NF155) antibodies.Thirteen anti-NF155+ and 35 anti-NF155 negative (anti-NF155neg) CIDP patients were included a case-control study. DRB1 HLA analyzed all while DQ only studied sharing DRB1*15 allele. In silico HLA-peptide binding NF155 antigenicity, predictions performed analyze overlap between...
<h3>Background and Objectives</h3> To study the clinical laboratory features of antineurofascin-155 (NF155)–positive autoimmune nodopathy (AN). <h3>Methods</h3> Patients with anti-NF155 antibodies detected on routine immunologic testing were included. Clinical characteristics, treatment response, functional scales (modified Rankin Scale [mRS] Inflammatory Rasch-built Overall Disability [I-RODS]) retrospectively collected at baseline follow-up. Autoantibody neurofilament light (NfL) chain...
Abstract Background Guillain–Barré syndrome (GBS) is an acute inflammatory neuropathy with a heterogeneous presentation. Although some evidences support the role of autoantibodies in its pathogenesis, target antigens remain unknown substantial proportion GBS patients. The objective this study to screen for targeting peripheral nerve components syndrome. Methods Autoantibody screening was performed serum samples from all patients included International Outcome by 11 different Spanish centres....
Autoantibody discovery in complex autoimmune diseases is challenging. Diverse successful antigen identification strategies are available, but, so far, have often been unsuccessful, especially the of protein antigens which conformational and post-translational modification critical. Our study assesses utility a human membrane secreted microarray technology to detect autoantibodies chronic inflammatory demyelinating polyradiculoneuropathy (CIDP).
Objetivos Evaluar la precisión de escala riesgo cardiovascular REGICOR en predicción eventos cardiovasculares (ECV) residentes Cataluña, con y sin síndrome metabólico (SM). Material métodos Estudio cohortes retrospectivo, seguimiento entre 2010 2020. Incluyó a personas 35 74 años, antecedente ECV registro puntuación base datos SIDIAP (Sistema Información para el Desarrollo Investigación Atención Primaria). La variable dependiente fue aparición del primer ECV. Las independientes principales...
Abstract Antibodies against myelin-associated glycoprotein (MAG) almost invariably appear in the context of an IgM monoclonal gammopathy associated neuropathy. Very few cases anti-MAG neuropathy lacking IgM-monoclonal have been reported. We investigated presence antibodies 69 patients fulfilling diagnostic criteria for CIDP. Anti-MAG were tested by ELISA and confirmed immunohistochemistry. identified four (5.8%) positive without detectable gammopathy. In two them, was detected at 3 4-year...
Background:The LRP1 (CR9) domain and, in particular, the sequence Gly 1127 -Cys 1140 (P3) plays a critical role binding and internalization of aggregated LDL (agLDL).We aimed to evaluate whether immunization with P3 reduces high-fat diet (HFD)-induced atherosclerosis.Methods: Female New Zealand White (NZW) rabbits were immunized primary injection four reminder doses (R1-R4) IrP (irrelevant peptide) or conjugated carrier.IrP P3-immunized randomly divided into normal group HFD-fed...
It is essential to find new biomarkers for severity stratification of patients with coronavirus disease (COVID-19). Growth differentiation factor 15 (GDF-15) upregulated in pathological conditions that involve inflammation and/or oxidative stress. We determined circulating levels GDF-15 and correlated them clinical laboratory parameters reflecting 84 COVID-19, finding were higher both than 20 healthy controls poorer respiratory function. also interleukin-6, C-reactive protein, ferritin...
To describe the clinical, serologic and histologic features of a cohort patients with brachio-cervical inflammatory myopathy (BCIM) associated systemic sclerosis (SSc) unravel disease-specific pathophysiologic mechanisms occurring in these patients.We reviewed immunologic, muscle MRI, nailfold videocapillaroscopy, biopsy, response to treatment data from 8 BCIM-SSc. We compared cytokine profiles between BCIM-SSc SSc without involvement controls. analyzed effect deregulated cytokines vitro...
In people with multiple sclerosis (pwMS), concern for potential disease exacerbation or triggering of other autoimmune disorders contributes to vaccine hesitancy. We assessed the humoral and T-cell responses SARS-CoV-2 after mRNA vaccination, changes in activity, development antibodies against central peripheral nervous system antigens.This was a prospective 1-year longitudinal observational study pwMS control group patients inflammatory neurologic (OIND) who received an vaccine. Blood...
Background: Different classification criteria for systemic lupus erythematosus (SLE) have been launched over the years. Our aim was to evaluate performance of EULAR/ACR-2019, SLICC-2012 and ACR-1997 in a cohort SLE patients with longstanding disease. Methods: Descriptive observational study 79 established SLE. The three sets were applied those patients. Results: Of patients, 70 women (88.6%), mean age 51.8 ± 14 years disease duration 15.2 11.5 sensitivity different were: 51.9%, 87.3% 86.1%...
El etambutol e isoniacida son tuberculostáticos para la tuberculosis multirresistente cuyo efecto adverso es neuropatía óptica, con pérdida de visión, alteración percepción los colores y escotomas cecocentrales.Se presenta el caso una mujer nigeriana 59 años antecedentes miliar que desarrolló óptica bilateral severa secundaria aetambutol La presión intraocular, fondo ojo polo anterior eran normales.La campimetría mostraba constricción periférica 360º escotoma central.La resonancia magnética...