A5027448725- Cardiovascular Disease and Adiposity
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- RNA modifications and cancer
- Circular RNAs in diseases
- Cancer-related Molecular Pathways
- Cancer-related molecular mechanisms research
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Effects of Exercise
- MicroRNA in disease regulation
- Calpain Protease Function and Regulation
- Cardiovascular Function and Risk Factors
- Atherosclerosis and Cardiovascular Diseases
- Cancer, Hypoxia, and Metabolism
- Protease and Inhibitor Mechanisms
- Diabetes Treatment and Management
- Cardiomyopathy and Myosin Studies
- Metabolism, Diabetes, and Cancer
- Proteins in Food Systems
- Viral Infections and Immunology Research
Institut d'Investigacions Biomèdiques de Barcelona
2018-2020
Consejo Superior de Investigaciones Científicas
2018-2020
Hospital de Sant Pau
2018-2020
Centro de Investigación en Red en Enfermedades Cardiovasculares
2020
Universidad Complutense de Madrid
2012
Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas
2012
Missense mutations in TP53 gene promote metastasis human tumours. However, little is known about the complete loss of function p53 tumour metastasis. Here we show that squamous cell carcinomas generated by specific ablation Trp53 mouse epidermis are highly metastatic. Biochemical and genome-wide mRNA miRNA analyses demonstrated metastases associated with early induction epithelial-mesenchymal transition (EMT) deregulated expression primary Increased miR-21 was observed undifferentiated,...
Background:The LRP1 (CR9) domain and, in particular, the sequence Gly 1127 -Cys 1140 (P3) plays a critical role binding and internalization of aggregated LDL (agLDL).We aimed to evaluate whether immunization with P3 reduces high-fat diet (HFD)-induced atherosclerosis.Methods: Female New Zealand White (NZW) rabbits were immunized primary injection four reminder doses (R1-R4) IrP (irrelevant peptide) or conjugated carrier.IrP P3-immunized randomly divided into normal group HFD-fed...
Epicardial adipose tissue (EAT) constitutes a novel parameter for cardiometabolic risk assessment and target therapy. Here, we evaluated the first time plasma microRNA (miRNA) profile as source of biomarkers epicardial fat volume (EFV). miRNAs were profiled in samples from 180 patients whose EFV was quantified using multidetector computed tomography. In screening study, 54 deregulated identified with high levels (highest tertile) compared matched low (lowest tertile). After filtering, 12...
Our aim was to identify biophysical biomarkers of ventricular remodelling in tachycardia-induced dilated cardiomyopathy (DCM). study includes healthy controls (N = 7) and DCM pigs 10). Molecular analysis showed global myocardial metabolic abnormalities, some them related hibernation failing hearts, supporting the translationality our model cardiac cardiomyopathy. Histological unorganized agglomerated collagen accumulation ventricles a higher percentage fibrosis right (RV) than left (LV)...
// Olga Bornachea 1 , Fernando F. López-Calderón 1, 2 Marta Dueñas Carmen Segrelles Corina Lorz Cristian Suárez-Cabrera María Marañón Beatriz Paradela-Dobarro Mirentxu Santos Jesús M. Paramio Molecular Oncology Unit, CIEMAT, 28040 Madrid, Spain Oncology, Institute of Biomedical Investigation University Hospital, 28041 Correspondence to: Santos, e-mail: mirentxu.santos@ciemat.es Paramio, jesusm.paramio@ciemat.es Keywords: p63, p53, metastasis, miRNA, skin Received: May 05, 2015 Accepted: June...