A5073356849- Hematopoietic Stem Cell Transplantation
- Breast Cancer Treatment Studies
- Breast Implant and Reconstruction
- Breast Lesions and Carcinomas
- Effects of Radiation Exposure
- Childhood Cancer Survivors' Quality of Life
- Hematological disorders and diagnostics
- Cancer Cells and Metastasis
- Renal and related cancers
- Mesenchymal stem cell research
- Cancer-related molecular mechanisms research
- Abdominal Surgery and Complications
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Ion channel regulation and function
- Viral gastroenteritis research and epidemiology
- Bone and Joint Diseases
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Metabolism and Genetic Disorders
- NF-κB Signaling Pathways
- Radiopharmaceutical Chemistry and Applications
- Women's cancer prevention and management
- Immunotherapy and Immune Responses
- Genetic and Kidney Cyst Diseases
- Esophageal and GI Pathology
Complejo Hospitalario de Salamanca
2012-2025
Instituto de Investigación Biomédica de Salamanca
2020
Universidad de Salamanca
2016
Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas
1990-2012
Centro de Biología Molecular Severo Ochoa
1993-1995
Missense mutations in TP53 gene promote metastasis human tumours. However, little is known about the complete loss of function p53 tumour metastasis. Here we show that squamous cell carcinomas generated by specific ablation Trp53 mouse epidermis are highly metastatic. Biochemical and genome-wide mRNA miRNA analyses demonstrated metastases associated with early induction epithelial-mesenchymal transition (EMT) deregulated expression primary Increased miR-21 was observed undifferentiated,...
Head and neck squamous cell carcinoma (HNSCC) is a common human neoplasia with poor prognosis survival that frequently displays Akt overactivation. Here we show mice displaying constitutive activity (myrAkt) in combination Trp53 loss stratified epithelia develop oral cavity tumors phenocopy HNSCC. The myrAkt lesions, making it possible model of dysplasia. malignant conversion these which hampered due to the induction premature senescence, achieved by subsequent ablation gene same cells vivo....
<title>Abstract</title> Background In recent years, breast surgery has undergone considerable development in the field of minimally invasive techniques such as endoscopic (E-NSM) or robotic (R-NSM) nipple sparing mastectomy. However, access to platforms is not always possible. this study, we present our initial experience with E-NSM through a single port and insufflation immediate reconstruction (SPIE-NSM + IBR) surgical option for Methods The medical records patients who underwent SPIE-NSM...
We have investigated whether a relatively low dose of 500 mGy X rays given as single acute irradiation at different stages pre- and postnatal development induces significant changes in the content femoral hematopoietic progenitors during 1-year period after irradiation. Data obtained show that, case 4-day-old embryos well 2-day, 8-day 12-week-old mice, this is below threshold capable inducing long-term impairment hematopoiesis mouse. Nevertheless, mice irradiated 13th or 17th day...
Grande, T. and Bueren, J. A. A New Approach to Evaluate the Total Reserve of Hematopoietic Progenitors after Acute Irradiation. Radiat. Res. 162, 397–404 (2004).Based on capacity certain hematopoietic growth factors mobilize progenitors from bone marrow peripheral blood, we have investigated whether number that can be mobilized blood irradiation correlates with radiation dose reflects total reserve survive exposure. In three different mouse strains, a close relationship was observed between...
Our experiments have focused on the analysis of residual haematopoietic damage in 8-day-old and 12-week-old mice X-irradiated with a single dose 7 Gy. In case adult mice, femoral splenic CFU-S, CFU-GM BFU-E showed persistent depletion these progenitor cells after irradiation. contrast, 1-week-old irradiated progressive recovery progenitors was observed, achieving essentially normal values 1 year The spleens however, contained significantly less than control group, mainly as consequence size...
The production of humoral factors that stimulate spleen colony-forming units (CFU-S) has been studied in irradiated mice using an vivo diffusion chamber assay. experiments show a significant release CFU-S takes place the first few days after irradiation with moderate doses 1.5 or 5 Gy. In contrast, amounts these was not seen animals either low (0.75 Gy) high (10 X rays. correlation observed between and hemopoietic regeneration kinetics suggests represent part physiological regulators...
We present the case of an 87-year-old male with Parkinson's disease, admitted to Emergency Room due acute abdomen, without leukocytosis or neutrophilia, PCR 0.74 and lactate 2.5. The emergency abdominal computed tomography (CT) scan showed a pneumoperitoneum significant intestinal pneumatosis on small bowel loops in right abdomen. There was 3.2 cm slight dilation, portal venous gas adequate opacification superior mesenteric artery its main branches. An laparotomy performed that subserosal...
Abstract Mice with skin tumors induced either by 7,12‐dimethylbenz[a]anthracene complete carcinogenesis or subcutaneous injection of a carcinogenic keratinocyte cell line showed moderate to severe splenomegaly as result an increase in splenic granulocyte‐macrophage and erythroid (erythroid burst‐forming unit) progenitors. To test whether the observed alterations involve release soluble factors epidermal component tumors, we used vitro approach. A series mouse lines resembling progressive...