A5063680146- Autoimmune and Inflammatory Disorders Research
- Adolescent and Pediatric Healthcare
- Kawasaki Disease and Coronary Complications
- Inflammasome and immune disorders
- Immunodeficiency and Autoimmune Disorders
- Orthopedic Infections and Treatments
- Vasculitis and related conditions
- Systemic Lupus Erythematosus Research
- Inflammatory Myopathies and Dermatomyositis
- Child and Adolescent Health
- Ocular Diseases and Behçet’s Syndrome
- Musculoskeletal Disorders and Rehabilitation
- Pediatric Pain Management Techniques
- Coronary Artery Anomalies
- Acute Lymphoblastic Leukemia research
- Hematological disorders and diagnostics
- Family and Disability Support Research
- Osteomyelitis and Bone Disorders Research
- Infectious Diseases and Tuberculosis
- Lymphoma Diagnosis and Treatment
- Diabetes and associated disorders
- Sarcoidosis and Beryllium Toxicity Research
- Pericarditis and Cardiac Tamponade
- Childhood Cancer Survivors' Quality of Life
- Innovations in Medical Education
Hospital Universitario 12 De Octubre
2015-2024
Departamento de Salud
2003-2024
Universidad Complutense de Madrid
2015-2024
Research Institute Hospital 12 de Octubre
2014-2022
Sanjay Gandhi Post Graduate Institute of Medical Sciences
2018
Istituto Giannina Gaslini
2017
Center for Rheumatology
2016
Hospital Universitario La Paz
2001-2009
Instituto Nacional de la Salud
1998-2007
Madrid Health Service
2007
(1) To determine the proportion of children evaluated for musculoskeletal pain in a paediatric primary care clinic over three year period; (2) to describe number office visits due pain; (3) categorise more common presenting complaints; and (4) characterise aetiology clinic.Retrospective chart review all > or =3 <15 years age an urban Madrid between 1 January 1997 31 December 1999.(1) A total 317 were throughout study. The prevalence increased as grew older, from 2.4-5.7% at 3 27.5-36% 14....
Abstract Objective To investigate the proxy‐reported health‐related quality of life (HRQOL) and its determinants in patients with juvenile idiopathic arthritis (JIA). Methods In this multinational, multicenter, cross‐sectional study, HRQOL JIA was assessed through Child Health Questionnaire (CHQ) compared that healthy children similar age from same geographic area. Potential included demographic data, physician's parent's global assessments, measures joint inflammation, Childhood Assessment...
Kawasaki disease (KD) is the leading cause of acquired heart in children United States. The etiology unknown. Data regarding presence T cell activation and its potential role pathogenesis have been conflicting. Expansion cells bearing V beta 2 8 has recently reported acute phase KD, which suggests that a superantigen may mediate process. To further assess phenotypes were evaluated by using flow cytometry large series patients, acutely during convalescence. Included this analysis assessments...
Objective. To seek insights into the heterogeneity of macrophage activation syndrome (MAS) complicating systemic juvenile idiopathic arthritis (sJIA) through analysis a large patient sample collected in multinational survey. Methods. International pediatric rheumatologists and hemato-oncologists entered their data, retrospectively, Web-based database. The demographic, clinical, laboratory, histopathologic, therapeutic, outcome data were analyzed relation to (1) geographic location caring...
1) To determine the number of primary care clinic visits attributable to musculoskeletal pain (MSP) in children >/=3 and <15 years age. 2) describe demographic characteristics this population assessed for limb/back pain. 3) characterize etiology an urban general pediatric Madrid, Spain.Prospective evaluation 1000 consecutive clinic. Inclusion criteria were age requested by family or patient. All consultations related MSP recorded via standard protocol data record form.During study period, 61...
Abstract Background This study aimed to assess the baseline characteristics and clinical outcomes of coronavirus disease 2019 (COVID-19) in pediatric patients with rheumatic musculoskeletal diseases (RMD) identify risk factors associated symptomatic or severe defined as hospital admission, intensive care admission death. Methods An observational longitudinal was conducted during first year SARS-CoV-2 pandemic (March 2020–March 2021). All attended at rheumatology outpatient clinics six...
Objective To evaluate the long-term safety profile of anakinra in patients with systemic juvenile idiopathic arthritis (sJIA). Methods Data from sJIA enrolled Pharmachild registry ( ClinicalTrials.gov : NCT03932344 ) prior to September 30, 2018, and treated were analyzed. The study endpoints occurrence non-serious adverse events (SAEs) at least moderate severity SAEs, including macrophage activation syndrome (MAS), duration treatment reasons for discontinuation. All analyzed overall by...
To define the toxicity of cystic fibrosis transmembrane conductance regulator gene (CFTR) therapy with a replication-deficient recombinant adenovirus (Av1Cf2) in nonhuman primate model, 10(10) plaque forming units (pfu) were instilled directly through bronchoscope into right lung 5 macaques, and lower dose 4 x 10(6) pfu was administered to 1 macaque. One sham-treated control received phosphate-buffered saline (PBS). The macaques evaluated sequentially by clinical examination, vital signs,...
Introduction Juvenile localized scleroderma (jlSc) usually responds well to treatment with methotrexate or mycophenolate. In case of nonresponse partial response, tocilizumab (TOC) appears be a promising option. Methods Participants the Pediatric Rheumatology Email Board were asked report patients jlSc treated TOC. Results Six centers responded and reported 11 patients. The mean age at disease onset was 5.5 years. Disease duration time initiation TOC 4.5 A total 5 had linear subtype, 2 Parry...
To develop and test a hybrid measure of muscle strength for juvenile dermatomyositis (JDM), which is based on the combination Manual Muscle Testing in 8 muscles (MMT-8) Childhood Myositis Assessment Scale (CMAS) but more comprehensive than former feasible latter.The MMT-8/CMAS (hMC) composed all items MMT-8 3 CMAS: time head lift, assessment abdominal muscles, floor rise. The score ranges 0-100, with 100 indicating normal strength. Validation procedures were conducted using large...
Background: NF-kB1 is a master regulator of both acquired and innate responses. NFKB1 loss-of-function mutations elicit wide clinical phenotype with asymptomatic individuals at one end the spectrum patients common variable immunodeficiency, combined immunodeficiency or autoinflammation other. Impairment immunity disseminated Mycobacterium genavense infection expands immunological NF-κB1 deficiency. Objective: Functional molecular characterization patient novel Methods: Circulating T, B,...