A5020941004- Bone and Joint Diseases
- Autoimmune and Inflammatory Disorders Research
- Inflammasome and immune disorders
- Hematological disorders and diagnostics
- Acute Lymphoblastic Leukemia research
- Bone health and treatments
- Orthopedic Infections and Treatments
- Adolescent and Pediatric Healthcare
- Osteomyelitis and Bone Disorders Research
- Vasculitis and related conditions
- Infectious Diseases and Tuberculosis
- Urticaria and Related Conditions
- Bone health and osteoporosis research
- Renal Diseases and Glomerulopathies
- Rheumatoid Arthritis Research and Therapies
- Sarcoidosis and Beryllium Toxicity Research
- Hip disorders and treatments
- Childhood Cancer Survivors' Quality of Life
- Musculoskeletal Disorders and Rehabilitation
- Immune Cell Function and Interaction
- Child and Adolescent Health
- Spondyloarthritis Studies and Treatments
- Kawasaki Disease and Coronary Complications
- Heparin-Induced Thrombocytopenia and Thrombosis
- Chronic Myeloid Leukemia Treatments
University of Calgary
2012-2025
Alberta Bone and Joint Health Institute
2025
Alberta Children's Hospital
2007-2023
McGill University
2012-2015
Brock University
2012-2015
Université de Montréal
2012-2015
University of British Columbia
2015
University of Ottawa
2012-2015
Dalhousie University
2015
University of Manitoba
2015
Vertebral fractures due to osteoporosis are a potential complication of childhood acute lymphoblastic leukemia (ALL). To date, the incidence vertebral during ALL treatment has not been reported.We prospectively evaluated 155 children with first 12 months therapy. Lateral thoracolumbar spine radiographs were obtained at baseline and months. bodies assessed for incident using Genant semiquantitative method, relevant clinical indices such as bone mineral density (BMD), back pain, presence...
The purpose of this article was to determine the incidence and predictors vertebral fractures (VF) during 4 years after diagnosis in pediatric acute lymphoblastic leukemia (ALL).Children were enrolled within 30 days chemotherapy initiation, with incident VF assessed annually on lateral spine radiographs according Genant method. Extended Cox models used assess association between clinical predictors.A total 186 children ALL completed baseline evaluation (median age, 5.3 years; interquartile...
To determine the incidence and longitudinal trends of Wegener's granulomatosis (WG) in pediatric population Southern Alberta over last 15 years.Fifteen cases childhood WG were confirmed. The average annual was 2.75 cases/million/year, with a steep increase 5 years to 6.39 cases/million/year.In during past comparable reported adults it seems be increasing. Further studies are required if this is regional or global phenomenon.
Background Confirmation of early long-bone epiphyseal osteonecrosis in pediatric patients with leukemia allows for medical and surgical intervention before articular surface collapse. MRI detects osteonecrosis, but multiple focused MR images are required to capture all lesions. Questions/purposes We determined whether whole-body (WB-MRI) could (1) assist diagnosing other osteonecroses, (2) characterize involvement, (3) detect preferential sites osteonecrosis. Patients Methods retrospectively...
To develop Canadian recommendations for the screening, monitoring, and treatment of uveitis associated with juvenile idiopathic arthritis (JIA). Recommendations were developed using Grading Assessment, Development, Evaluation (GRADE)-ADOLOPMENT approach. A working group 14 pediatric rheumatologists, 6 ophthalmologists, 2 methodologists, 3 caregiver/patient representatives reviewed recent American College Rheumatology (ACR)/Arthritis Foundation (AF) worked in pairs to evidence-to-decision...
Abstract: Discoid lupus erythematosus (DLE) is rare in childhood. We report the case of a 5‐year‐old girl who presented with erythematous scaly plaques, scarring alopecia, involving approximately 40% her scalp. Histopathology confirmed diagnosis DLE. Treatment intravenous methylprednisolone, hydroxychloroquine, oral prednisone, topical corticosteroids, and sunscreen lead to reversal alopecia re‐growth hair.
Interference with the molecular mechanisms that generate tumor supportive niches in bone microenvironment is a rational approach to inhibit growth of hematological malignancies. However, advancement knowledge this area has been slowed down by lack vitro models facilitate screening potential candidate agents. The rare cases acute lymphoblastic leukemia (ALL) children presenting extensive involvement may represent an exaggerated form some aspects normal tumor-bone interactions. Thus, these can...
Osteonecrosis (ON) is a serious complication of childhood acute lymphoblastic leukemia. We determined the prevalence osteonecrotic lesions in our patient population by one-time multisite magnetic resonance imaging (MRI) more than 1 year following leukemia therapy. MRI findings were evaluated relationship to clinical factors (including longitudinal changes bone mineral density [BMD]). Eighty-six children enrolled Steroid Associated Osteoporosis Pediatric Population (STOPP) study for ON at 3.1...
ABSTRACT Due to concerns about cumulative radiation exposure in the pediatric population, it is not standard practice perform spine radiographs most conditions that predispose vertebral fracture (VF). In this study we examined accuracy of two clinical predictors, back pain and lumbar bone mineral density (LS BMD), derive four case-finding paradigms for detection prevalent VF (PVF). Subjects were 400 children at risk PVF (leukemia 186, rheumatic disorders 135, nephrotic syndrome 79). Back was...
A girl in middle childhood was referred to rheumatology with a 1-month history of progressive skull pain, preceded by fleeting musculoskeletal symptoms. Apart from scaly rash on her scalp, she well, moderately elevated inflammatory markers. Skull imaging (radiographs, CT and MRI) revealed osteolytic lesions, soft tissue swelling pachymeningeal enhancement at frontal temporal convexities. Langerhans cell histiocytosis, bone infection/inflammation or malignancy considered. Skin biopsies...
Abstract Generalized pustular psoriasis (GPP) is a severe form of psoriasis, which rare in pediatric and adult patients. It characterized by sterile lesions that appear on erythematous skin, associated with systemic features. A recent identification mutations the IL36RN gene some GPP patients has led to diagnosis new autoinflammatory disease, interleukin‐36‐receptor antagonist deficiency (DITRA). DITRA represents an emerging group diseases hyperkeratotic skin involvement, called...
ABSTRACT Vertebral fractures are clinically important sequelae of a wide array pediatric diseases. In this study, we examined the accuracy case-finding strategies for detecting incident vertebral (IVF) over 2 years in glucocorticoid-treated children (n = 343) with leukemia, rheumatic disorders, or nephrotic syndrome. Two clinical situations were addressed: prevalent fracture (PVF) scenario (when baseline PVF status was known), which assessed utility and low lumbar spine bone mineral density...
Granulomatosis with Polyangiitis (GPA) is a rare and potentially lethal vasculitis, which predominantly affects small vessels. GPA can present palpable purpura, hemorrhagic macules bullae similar to skin lesions found in the most common vessel vasculitis childhood, Henoch-Schoenlein Purpura (HSP), leading diagnostic confusion.
Background: The characteristics and burden of childhood arthritis have never been studied on a worldwide basis. We aimed to investigate prevalence disease categories, treatment modalities status across different geographic areas.
We describe an 11-year prospective clinical and radiologic course of a 6-year-old boy with bilateral Legg-Calvé-Perthes disease, who was treated intravenous pamidronate (IV-PAM). His baseline radiographs showed grade IV avascular necrosis/Catterall stage IV, at worst he progressed to lateral pillar/Herring C bilaterally. disease initially extremely functionally limiting expected poor outcome eventual joint replacement. Because IV-PAM stops bone breakdown allows for ongoing formation while...
Background/Purpose: To estimate the incidence of periodic fever syndromes in Canadian paediatric population, to describe patterns presentation, and raise awareness medical community. Methods: This study was initiated though Pediatric Surveillance Program (CPSP), is being carried out over a three year period which will conclude September 2014. The case definition includes patients less than 18 years age presenting with newly diagnosed syndrome. Conditions under surveillance...
ObjectivesTo evaluate in a prospective international cohort of juvenile systemic lupus erythematosus (JSLE) with active renal disease (ARD) response to therapy over 24-month period. Patients & Methods134 new onset and 106 flared JSLE patients ARD, age < 18 years, were included.JSLE activity parameters therapeutic approaches analyzed at baseline, 6, 12 24 months, 4 geographic areas.Response was assessed according the PRINTO/ACR criteria "as observed" as "per intention-to-treat (ITT)".