A5075139247- Kawasaki Disease and Coronary Complications
- Autoimmune and Inflammatory Disorders Research
- Adolescent and Pediatric Healthcare
- Coronary Artery Anomalies
- Systemic Lupus Erythematosus Research
- Renal Diseases and Glomerulopathies
- Immunodeficiency and Autoimmune Disorders
- Vasculitis and related conditions
- Inflammasome and immune disorders
- Parvovirus B19 Infection Studies
- Mechanical Circulatory Support Devices
- Immune Cell Function and Interaction
- Cardiac Structural Anomalies and Repair
- COVID-19 Clinical Research Studies
- Venous Thromboembolism Diagnosis and Management
- Family and Disability Support Research
- Eosinophilic Disorders and Syndromes
- Antifungal resistance and susceptibility
- Vascular Tumors and Angiosarcomas
- Nail Diseases and Treatments
- Drug-Induced Adverse Reactions
- Streptococcal Infections and Treatments
- Tuberculosis Research and Epidemiology
- Blood Coagulation and Thrombosis Mechanisms
- Inflammatory Myopathies and Dermatomyositis
Institute of Child Health
2016-2025
Apollo Gleneagles Hospitals
2024
Apollo Hospitals
2022
Fortis Hospital
2021
Bristol Royal Hospital for Children
2014
To describe the clinical, laboratory, and histopathologic features, current treatment, outcome of patients with macrophage activation syndrome (MAS) complicating systemic juvenile idiopathic arthritis (JIA).In this multinational, multicenter study, pediatric rheumatologists hemato-oncologists entered patient data collected retrospectively into a web-based database.A total 362 patients, 22% whom had MAS at onset JIA, were included in study by 95 investigators from 33 countries. The most...
To develop a composite disease activity score for systemic JIA (sJIA) and to provide preliminary evidence of its validity.The Juvenile Arthritis Disease Activity Score (sJADAS) was constructed by adding the four items original JADAS fifth item that aimed quantify features. Validation analyses were conducted on patients with definite or probable/possible sJIA enrolled at first visit time flare, who had active manifestations, which should include fever. Patients reassessed 2 weeks 3 months...
Abstract Background Post‐COVID multisystem hyperinflammatory syndrome in children (MISC) has clinical and laboratory similarities with Kawasaki disease (KD). Inflammatory markers like C‐reactive protein (CRP), interleukin 6 (IL6) as well N‐terminal probrain natriuretic peptide (NT‐proBNP) are elevated both. This study attempts a comparative analysis of the 3 an attempt at early differentiation for planning appropriate management. Methodology analytical conducted Institute Child Health,...
A term infant girl with uneventful antenatal history had an erythematous rash followed by fever from day 8. She was diagnosed late-onset sepsis and treated accordingly. received immunoglobulin for persistent thrombocytopenia, after which there transient improvement. The patient transferred to our hospital on 25 recurrence of fever, watery diarrhea, a generalized maculopapular rash. On admission, she tachycardia, tachypnoea, anemia, hypoalbuminemia, edema. Reverse transcriptase-polymerase...
Abstract Background: While classical Kawasaki disease (KD) is easily diagnosed by a well-established set of diagnostic criteria, the diagnosis incomplete KD remains elusive. Clinical Description: A 1-year-old girl presented with high fever, painful swelling, and redness over anterior part neck, associated swallowing difficulty. There was no rash, eyes, or lymphadenopathy. Management Outcome: Considering cellulitis antibiotics were initiated. She developed stridor received dexamethasone....
Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome reflects a serious hypersensitivity reaction to drugs, is characterized by skin rash, fever, lymph node enlargement, internal organ involvement. So far, numerous drugs such as sulfonamides, phenobarbital, sulfasalazine, carbamazepine, phenytoin have been reported cause DRESS syndrome. We report case of 10-year-old girl who developed clinical manifestations lymphadenopathy, hypereosinophilia, visceral involvement (hepatitis...
We present clinical, biochemical, and histopathological characteristics treatment outcomes of biopsy proven childhood lupus nephritis (LN) from a low/middle income setting treated in the current era increased use Mycophenolate Mofetil (MMF) biologics.Retrospective observational study children (1-18 years) with LN 01.01.2010 to 31.01.2020.60 met our inclusion criteria (80%, n = 48 were females). The median age at diagnosis was 11 (IQR: 9-12) years. most common extra-renal manifestation...
Abstract Drug rash, eosinophilia, and systemic symptoms ( DRESS ) syndrome is a severe hypersensitivity reaction that usually occurs within 6 weeks of exposure to the offending drug. Diagnosis straightforward in patients with pyrexia, skin hepatitis, eosinophilia preceding history agents often associated syndrome, such as aromatic anticonvulsants sulfa drugs, but diagnosis may still be challenge. We report 4‐year‐old child probable complicated by multiple hematologic complications developed...
Macrophage activation syndrome (MAS) is a dreaded complication of systemic inflammatory diseases and most commonly seen in juvenile idiopathic arthritis (sJIA). We evaluate the clinical features, laboratory findings outcomes pediatric MAS, assess response to different pharmacological therapies, finally identify possible factors associated with an unfavorable outcome.This retrospective analysis data from patients diagnosed as having admitted between July 2008 April 2018 into Department...