A5001567119- Autoimmune and Inflammatory Disorders Research
- Adolescent and Pediatric Healthcare
- Inflammasome and immune disorders
- Rheumatoid Arthritis Research and Therapies
- Ocular Diseases and Behçet’s Syndrome
- Systemic Lupus Erythematosus Research
- Kawasaki Disease and Coronary Complications
- Family and Disability Support Research
- Acute Lymphoblastic Leukemia research
- Vasculitis and related conditions
- Childhood Cancer Survivors' Quality of Life
- Renal function and acid-base balance
- Pericarditis and Cardiac Tamponade
- COVID-19 Clinical Research Studies
- Pulmonary Hypertension Research and Treatments
- Autism Spectrum Disorder Research
- Retinal and Optic Conditions
- Neurogenetic and Muscular Disorders Research
- Cardiac Imaging and Diagnostics
- Respiratory Support and Mechanisms
- Neurological Disorders and Treatments
- Renal Diseases and Glomerulopathies
- Skin and Cellular Biology Research
- Coronary Artery Anomalies
- Long-Term Effects of COVID-19
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2016-2025
University of Milan
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2007-2024
Ospedale Maggiore
2017-2024
Belarusian Medical Academy of Post-Graduate Education
2020
Rambam Health Care Campus
2020
Office of Adolescent Health
2020
Shupyk National Healthcare University of Ukraine
2020
Gazi University
2019
Bambino Gesù Children's Hospital
2018
Abstract Objective To develop and validate a composite disease activity score for juvenile idiopathic arthritis (JIA), the Juvenile Arthritis Disease Activity Score (JADAS). Methods The JADAS includes 4 measures: physician global assessment of activity, parent/patient well‐being, active joint count, erythrocyte sedimentation rate. These variables are part American College Rheumatology (ACR) Pediatric 30 (Pedi 30), Pedi 50, 70 criteria improvement. Validation analyses were conducted on...
To report methodology and overall clinical, laboratory radiographic characteristics for Henoch-Schönlein purpura (HSP), childhood polyarteritis nodosa (c-PAN), c-Wegener granulomatosis (c-WG) c-Takayasu arteritis (c-TA) classification criteria.The preliminary Vienna 2005 consensus conference, which proposed criteria paediatric vasculitides, was followed by a EULAR/PRINTO/PRES - supported validation project divided into three main steps. Step 1: retrospective/prospective web-data collection...
The Lupus Foundation of America (LFA) convened an international working group to obtain a consensus definition disease flare in lupus. With help from the Paediatric Rheumatology International Trials Organization (PRINTO), two web-based Delphi surveys physicians were conducted. Subsequently, LFA held second conference followed by third survey reach community-wide agreement for definition. Sixty-nine 120 (57.5%) polled responded first survey. Fifty-nine responses available draft 12 preliminary...
Objective. To develop and test a new multidimensional questionnaire for assessment of children with juvenile idiopathic arthritis (JIA) in standard clinical care. Methods. The Juvenile Arthritis Multidimensional Assessment Report (JAMAR) includes 15 parent or patient-centered measures items that assess well-being, pain, functional status, health-related quality life, morning stiffness, disease activity, status course, joint disease, extraarticular symptoms, side effects medications,...
Objective. To evaluate the measurement properties of 21-numbered circle visual analog scales (VAS) and traditional 10-cm horizontal line VAS for physician parent subjective ratings in children with juvenile idiopathic arthritis (JIA). Methods. We studied 2 patient samples whom global rating overall disease activity, child’s well-being, intensity pain were performed using (n = 397) or 471). The performances formats examined by assessing construct validity, score distribution, responsiveness...
Abstract Background Italy was the first Western country to be hit by SARS-CoV-2 epidemic. There is now mounting evidence that a minority of children infected with SARS-CoV2 may experience severe multisystem inflammatory syndrome, called Multisystem Syndrome associated Coronavirus Disease 2019 (MIS-C). To date no universally agreed approach available for this disease. Main body as facing second hity COVID-19 cases, we fear recrudescence MIS-C cases. We have, therefore, decided prepare report...
Abstract Objective To develop and validate a new short simple measure of physical function in children with juvenile idiopathic arthritis (JIA). Methods The Juvenile Arthritis Functionality Scale (JAFS) is 15‐item questionnaire that explores 3 body areas (lower limbs, hand/wrist, upper segment). Validation the Italian version instrument was accomplished by evaluating 211 consecutive JIA patients ages 2.2–18 years. instrument's feasibility, face content validity, construct discriminative...
Behçet's disease is a rare multi-systemic inflammatory with unknown etiology which involves principally oral and genital mucosa, skin eyes. Average age at onset of the about 25-30 years, but it may be diagnosed before 16. It not very in Italy, even though there are limited data concerning epidemiology. Aim this study to describe baseline an Italian cohort patients as having BD or probable BD. We described first national epidemiological on children coming from 16 Pediatric Rheumatologic...
Coronavirus disease 19 is a global healthcare emergency with high lethality rate. Relevant inflammatory cytokine storm associated severity of disease, and IL1 inhibition cornerstone treatment for hyperinflammatory diseases. We present here the case patient critical COVID-19 successfully treated IL-1 receptor antagonist (anakinra).
Anti-TNF-α agents have significantly changed the management of juvenile idiopathic arthritis (JIA). We evaluated safety and efficacy adalimumab (ADA) infliximab (IFX) for treatment JIA-associated uveitis in patients treated ≥ 2 years.Patients with IFX ADA were managed by a standardized protocol data entered ORCHIDEA registry. At baseline, all refractory to standard immunosuppressive or corticosteroid-dependent. Data recorded every 3 months course, number/type ocular flares complications,...
To develop a composite disease activity score for systemic JIA (sJIA) and to provide preliminary evidence of its validity.The Juvenile Arthritis Disease Activity Score (sJADAS) was constructed by adding the four items original JADAS fifth item that aimed quantify features. Validation analyses were conducted on patients with definite or probable/possible sJIA enrolled at first visit time flare, who had active manifestations, which should include fever. Patients reassessed 2 weeks 3 months...
To explore the parent and child acceptable symptom state in juvenile arthritis (JA-PASS JA-CASS, respectively) estimate JA-PASS JA-CASS cutoff values for outcome measures.Children with idiopathic (JIA) their parents completed a multi-dimensional questionnaire that included parent-reported child-reported outcomes question about whether they considered disease as satisfactory. Additional assessments demographic data, physician-reported outcomes, acute-phase reactant levels. Stepwise logistic...
The epidemiology of juvenile idiopathic arthritis (JIA) is variable worldwide. In particular, a wide disparity exists in the prevalence diverse disease subtypes across different geographic areas. therapeutic approach to JIA not standardized and no established widely accepted guidelines are available. past decade, there have been important progresses management disease, but availability novel costly biologic medications uniform throughout world. This issue may significant impact on prognosis,...
Abstract Objective The main aim of this study was to define the best treatment option for multisystem inflammatory syndrome in children (MIS-C) and analyse role anakinra. Methods This is a multicentre retrospective cohort study. Patients were treated according attending physician’s decision. patients divided into four groups on basis first at time admittance: (i) IVIG, (ii) IVIG methylprednisolone (≤2 mg/kg/day), (iii) with high-dose (>2 mg/kg/day) (iv) anakinra or without and/or...
To investigate the disease outcomes of a cross-sectional sample children with longstanding juvenile idiopathic arthritis (JIA) seen between September 2002 and December 2006, to provide benchmarking obtained current treatment.All consecutive patients were included if they met following criteria: diagnosis JIA, duration > or = 5 years, informed consent. Outcome assessments activity, inactive disease, minimal pain, physical function, health-related quality life (HRQOL), auxometric measurements,...
To develop and validate a new short simple measure of health-related quality life (HRQL) in children with juvenile idiopathic arthritis (JIA).The Paediatric Rheumatology Quality Life Scale (PRQL) is 10-item questionnaire that explores HRQL two domains: physical health (PhH) psychosocial (PsH). Validation the parent proxy report child self-report versions instrument was accomplished by evaluating 472 JIA patients approximately 800 healthy children. analyses included assessment feasibility,...