A5024285334- Advanced MRI Techniques and Applications
- HIV Research and Treatment
- Scientific Computing and Data Management
- HIV/AIDS drug development and treatment
- Superconducting Materials and Applications
- MRI in cancer diagnosis
- HIV/AIDS Research and Interventions
- Atomic and Subatomic Physics Research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Organ Donation and Transplantation
- Pediatric Urology and Nephrology Studies
- HIV-related health complications and treatments
- Delphi Technique in Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Long-Term Effects of COVID-19
- Hepatitis C virus research
- Organ Transplantation Techniques and Outcomes
- HIV, Drug Use, Sexual Risk
- Distributed and Parallel Computing Systems
- Cytomegalovirus and herpesvirus research
- COVID-19 and healthcare impacts
- SARS-CoV-2 detection and testing
- COVID-19 Impact on Reproduction
- Medical Imaging and Pathology Studies
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2018-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2020-2024
Ospedale Maggiore
2020-2024
University of Milan
2011-2022
University Orthopedics Center
2021
Institute for Transfusion Medicine
2021
Luigi Sacco Hospital
1987-2019
Ospedale Bassini
1998-2018
University of Milano-Bicocca
2017
Azienda Ospedaliera Universitaria Pisana
2004-2011
HIV persistence during combination antiretroviral therapy (cART) is the principal obstacle to cure. Mechanisms responsible for remain uncertain; infections may be maintained by and clonal expansion of infected cells or ongoing replication in anatomic locations with poor penetration. These mechanisms require different strategies eradication, determining their contributions essential. We used phylogenetic approaches investigate, at DNA level, populations blood, lymphoid, other tissues obtained...
The prevalence of the most severe forms HIV-associated neurocognitive disorders (HAND) is decreasing due to worldwide availability and high efficacy antiretroviral treatment (ART). However, several grades HIV-related cognitive impairment persist with effective ART remain a clinical concern for people HIV (PWH). pathogenesis these impairments has yet be fully understood probably multifactorial. In PWH undetectable peripheral HIV-RNA, presence viral escapes in cerebrospinal fluid (CSF) might...
Vaccines against COVID-19 are a powerful tool to control the current SARS-CoV-2 pandemic. A thorough description of their immunogenicity among people living with HIV (PLWHIV) is necessary. We aimed assess mRNA-1273 vaccine PLWHIV.In this prospective cohort, adult PLWHIV outpatients were enrolled during Italian vaccination campaign. Enrolment was allowed irrespective ongoing combination antiretroviral therapy (ART), plasma viral load and CD4+ T cell count. two-dose regimen mRNA-1273,...
•COVID-19 vaccination is a promising tool to control the SARS-CoV-2 pandemic.•Vaccinations in people living with HIV have been associated transient RNA increase.•We report case of non-suppressible viremia after COVID-19 vaccination. The latent viral reservoir main obstacle preventing eradication, as virus persists, integrated long-lived quiescent cells. Immune stimulatory by their nature, vaccines evaluated possible agents for 'shock and kill' strategies, which rely on using...
The HIV-1 clade C is prevalent worldwide and spread from Africa to South East Asia America early in the course of epidemic. As a consequence migration waves about 13% Italian epidemic sustained by this clade. Two hundred fifty-four pol sequences ARCA database collected during 1997-2011 were analyzed. Epidemiological networks geographical fluxes identified through phylogeny using Bayesian approaches. Patients' country origin was Italy, Africa, America, for 44.9%, 23.6%, 4.7%, 1.6%,...
Background Subtype A accounts for only 12% of HIV-1 infections worldwide but predominates in Russia and Former Soviet Union countries Eastern Europe. After an early propagation via heterosexual contacts, this variant spread explosively among intravenous drug users. distinct A1 Greece Albania, which penetrated directly from Africa. Clade 12.5% non-B subtypes Italy, being the most frequent after F1 subtype. Aim study was to investigate circulation subtype Italy trace its origin diffusion...
Despite the well-known efficacy of anti-COVID-19 vaccines in preventing morbidity and mortality, several vaccinated individuals are diagnosed with SARS-CoV-2 breakthrough infection, which might require hospitalisation. This multicentre, observational, retrospective study aimed to investigate clinical characteristics outcomes vs. non-vaccinated patients, both hospitalised infection 3 major hospitals Northern Italy. Data collection was retrospective, paper electronic medical records adult...
COVID-19 pandemic challenged the UNAIDS 90-90-90 targets. How affected HIV retention in care and whether it has disproportionally migrant people with (PWH) remained to be investigated. PWH ICONA Cohort follow-up each of study periods were included: 01/09/2019-29/02/2020 (pandemic period) 01/03/2018-31/08/2018 (historical period, as a control). Risk temporary loss (LTFU, defined no data recorded for person one year) was analyzed by logistic regression, status main exposure variable....
In a setting of free access to HIV care, we compared the early treatment outcomes HIV-infected undocumented migrants (UMs), documented (DMs), and Italian subjects.The clinical data 640 Italians 245 who started combined antiretroviral therapy (cART) at an clinic in Milan, Italy, were reviewed. The mainly Latin Americans (83 DMs 56 UMs) or sub-Saharan Africans (52 11 UMs), but minority other origin (33 10 UMs). Retention follow-up suppression between UMs, DMs, natives 12 months ± 90 days after...
Nocardia is primarily considered an opportunistic pathogen and affects patients with impaired immune systems, solid-organ transplant recipients (SOTRs), haematologic malignancies. We present the cases of six diagnosed nocardiosis at our center in last two years, describing various predisposing conditions alongside clinical manifestation, diagnostic workup, treatment course. Moreover, we propose a brief literature review on infections immunocompromised host, focusing SOTRs haematopoietic stem...