A5022076964- HIV Research and Treatment
- Algebraic Geometry and Number Theory
- Gut microbiota and health
- Advanced Algebra and Geometry
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Cytomegalovirus and herpesvirus research
- Immune Cell Function and Interaction
- Clostridium difficile and Clostridium perfringens research
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- COVID-19 and healthcare impacts
- Algebraic structures and combinatorial models
- Homotopy and Cohomology in Algebraic Topology
- HIV-related health complications and treatments
- Geometry and complex manifolds
- Alkaloids: synthesis and pharmacology
- Immunodeficiency and Autoimmune Disorders
- Analytic and geometric function theory
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Healthcare cost, quality, practices
- COVID-19 Impact on Reproduction
- Workplace Violence and Bullying
- Mathematics and Applications
Vita-Salute San Raffaele University
2025
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2025
Ospedale Maggiore
2021-2023
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2021-2023
Vivantes Klinikum
2023
University of Milan
1997-2021
Azienda Socio Sanitaria Territoriale Santi Paolo e Carlo
2020-2021
University of Pavia
2020-2021
Institute for Transfusion Medicine
2021
University Orthopedics Center
2021
Objective: HIV-infected individuals with incomplete CD4+ T-cell recovery upon combination antiretroviral therapy (cART) display high levels of immune activation and microbial translocation. However, whether a link exists between gut damage poor immunological reconstitution remains unknown. Design: Cross-sectional study the gastrointestinal tract in late cART-treated individuals: 15 nonresponders (CD4+ <350 cells/μl and/or delta change from baseline <30%); full responders >350 >30%). Methods:...
Background: We explored the long-term effects of cART on markers gut damage, microbial translocation, and paired gut/blood microbiota composition, with a focus role exerted by different drug classes. Methods: enrolled 41 naïve HIV-infected subjects, undergoing blood fecal sampling prior to (T0) after 12 (T12) 24 (T24) months therapy. Fifteen HIV-uninfected individuals were as controls. analyzed: (i) T-cell homeostasis (flow cytometry); (ii) translocation (sCD14, EndoCab, 16S rDNA); (iii)...
Objective: Analysis of functionally defined T-cell differentiation in HIV-infected patients with low CD4+ on virologically suppressive HAART is crucial to design clinically efficacious treatments. Methods: We cross-sectionally investigated the maturation (CD45RA/CCR7, CD7) and function [antigen-specific enzyme-linked immunosorbent spot assay (ELISPOT), interleukin-2 (IL-2)/interferon-γ-producing cells] CD8+ T cells 34 immunological nonresponders (INRs): cell count less than or equal 200...
Abstract Thickening of the gallbladder wall is often associated with acute or chronic cholecystitis, adenomyomatosis and carcinoma seen in context liver systemic diseases (acute hepatitis, cirrhosis, sepsis). Here we present a case 61 y.o. man focal thickening wall, whom all imaging techniques were inconclusive. Pathological examination resected revealed acute-on-chronic cholecystitis. We describe cholecystitis absence classic clinical findings (Murphy’s sign, fever, gallstones, hydrops,...
Abstract We show that the hyper‐Kähler varieties of OG10‐type constructed by Laza–Saccà–Voisin (LSV) verify Lefschetz standard conjecture. This is an application a more general result, stating certain Lagrangian fibrations this The main technical assumption result fibration satisfies hypotheses Ngô's support theorem. Verifying LSV tenfolds do satisfy those independent interest. Another point interest paper definition and study conjecture in relative setting, its relation to classical absolute case.
We investigated the effect of LPS in vitro stimulation on T-cell activation HIV-infected patients with different CD4+ recovery HAART. PBMCs from 30 HIV-positive, HAART-treated, aviremic individuals reconstitution (Low Responders: < 350/μL; Intermediate 350–599/μL; High ≥ 600/μL) were cultured and proportion HLA-DR/CD38- Ki67-expressing CD4+/CD8+ T-cells was measured (flow cytometry). Upon stimulation, significantly higher CD8+HLA-DR+ cells shown LR IR versus HIV-negative controls. While...
Despite the well-known efficacy of anti-COVID-19 vaccines in preventing morbidity and mortality, several vaccinated individuals are diagnosed with SARS-CoV-2 breakthrough infection, which might require hospitalisation. This multicentre, observational, retrospective study aimed to investigate clinical characteristics outcomes vs. non-vaccinated patients, both hospitalised infection 3 major hospitals Northern Italy. Data collection was retrospective, paper electronic medical records adult...
Abstract Background Bendamustine, used for the treatment of indolent B-cell non-Hodgkin lymphoma and chronic lymphocytic leukemia, is known to cause prolonged myelosuppression lymphocytopenia has been associated with risk developing serious fatal infections. While reports localized CMV infections in asymptomatic patients exist, disseminated disease not described. Case presentation We report first case infection a 75-year-old male diagnosed lymphoplasmacytic lymphoma/Waldenström...
The association between chronic autoimmune thyroiditis (CAT) and differentiated thyroid cancer (DTC) remains controversial. incidence of DTC increases when screening procedures are implemented, as typically occurs in CAT patients being routinely submitted to ultrasound (US). aim this study was longitudinally evaluate the long-term development with CAT.A retrospective longitudinal cohort designed. For study, 510 a 10-year follow-up were enrolled. Patients divided two groups according presence...
We aimed to document data on the epidemiology and factors associated with clinical course leading death of patients hospitalised COVID-19.
We prove that any commutative group scheme over an arbitrary base of finite type a field with connected fibers and admitting relatively ample line bundle is polarizable in the sense Ng\^o. This extends applicability Ng\^o's support theorem to new cases, for example Lagrangian fibrations integral has consequences construction algebraic classes. Comment: comments welcome
We show that the hyper-Kähler varieties of OG10-type constructed by Laza-Saccà-Voisin (LSV) verify Lefschetz standard conjecture. This is an application a more general result, stating certain Lagrangian fibrations this The main technical assumption result fibration satisfies hypotheses Ngô's support theorem. Verifying LSV tenfolds do satisfy those independent interest. Another point interest paper definition and study conjecture in relative setting, its relation to classical absolute case.
HIV infection causes the progressive depletion of CD4+ T-lymphocytes and profound modifications T-cell homeostasis, which persist despite virologically-suppressive treatment have been linked to a worse clinical outcome. Enduring alterations gastrointestinal tract may represent underlying pathogenic mechanisms these phenomena. Twenty-six HIV-infected subjects were assessed over 12-month period following introduction antiretroviral therapy. 18 uninfected individuals enrolled as controls....
Despite integrase strand transfer inhibitor (INSTI)-containing regimens now being considered a preferred option for both initial therapy and switching strategies in virologically suppressed patients, their effects on lymphocyte phenotypes functions the course of effective combination antiretroviral (cART) are still unclear. Thus, we investigated effect 24-week elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate (EVG/c/FTC/TDF) regimen T cell compartment HIV reservoirs...