A5046409179- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Viral Infections and Immunology Research
- SARS-CoV-2 detection and testing
- COVID-19 Impact on Reproduction
- Vaccine Coverage and Hesitancy
- Viral gastroenteritis research and epidemiology
- Respiratory viral infections research
- Retinal and Optic Conditions
- Drug-Induced Adverse Reactions
- Clostridium difficile and Clostridium perfringens research
- Cytomegalovirus and herpesvirus research
- Genetic and phenotypic traits in livestock
- Urticaria and Related Conditions
- Milk Quality and Mastitis in Dairy Cows
- Viral-associated cancers and disorders
- Sepsis Diagnosis and Treatment
- Fungal Infections and Studies
- Cystic Fibrosis Research Advances
- Image Processing Techniques and Applications
- Blood groups and transfusion
- Oral microbiology and periodontitis research
- Thermal Regulation in Medicine
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- COVID-19 epidemiological studies
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2020-2024
Azienda Ospedaliera di Desio e Vimercate
2024
Ospedale Maggiore
2020-2022
Istituti di Ricovero e Cura a Carattere Scientifico
2020-2021
University of Milano-Bicocca
2012-2016
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
2015
We report a rapid increase in enterovirus D68 (EV-D68) infections, with 139 cases reported from eight European countries between 31 July and 14 October 2021. This upsurge is line the seasonality of EV-D68 was presumably stimulated by widespread reopening after COVID-19 lockdown. Most were identified September, but more are to be expected coming months. Reinforcement clinical awareness, diagnostic capacities surveillance urgently needed Europe.
Abstract Enterovirus D68 (EV-D68) infections are associated with severe respiratory disease and acute flaccid myelitis (AFM). The European Non-Polio Network (ENPEN) aimed to investigate the epidemiological genetic characteristics of EV-D68 its clinical impact during fall-winter season 2021–2022. From 19 countries, 58 institutes reported 10 481 (6.8%) EV-positive samples which 1004 (9.6%) were identified as (including 852 samples). Clinical data for 969 cases; 78.9% in children (0–5 years);...
Vaccines against COVID-19 are a powerful tool to control the current SARS-CoV-2 pandemic. A thorough description of their immunogenicity among people living with HIV (PLWHIV) is necessary. We aimed assess mRNA-1273 vaccine PLWHIV.In this prospective cohort, adult PLWHIV outpatients were enrolled during Italian vaccination campaign. Enrolment was allowed irrespective ongoing combination antiretroviral therapy (ART), plasma viral load and CD4+ T cell count. two-dose regimen mRNA-1273,...
: Coronavirus Disease 2019 (COVID-19) has rapidly spread worldwide, becoming an unprecedented public health emergency. Rapid detection of Severe Acute Respiratory Syndrome 2 (SARS-CoV-2) suspected cases is crucial to control the infection. We aimed evaluate time length negativization from onset symptoms in healthcare workers (HCWs) with COVID-19, and significant variations cycle threshold (CT) values gene positivity (E, RdRP, N genes) among positive individuals who returned work.
Great expectations are placed in vaccines against COVID-19 to control the pandemic. We reviewed antibody titres a cohort of healthcare workers (HCWs) vaccinated with BNT162b2 assess influence previous infection on them. stratified results according individual history nasopharyngeal swab (NPS) and symptoms. Among 3475 HCWs highest were recorded among those infected more than 6 months before vaccination, independently symptoms, followed by less especially uninfected HCWs. Vaccination can boost...
Abstract Coronavirus disease 2019 (COVID-19) is a pandemic viral affecting also obstetric patients and uncertainties exist about the prognostic role of inflammatory biomarkers hemocytometry values in with this infection. To clarify that, we have assessed several variables cohort hospitalized COVID-19 correlated at admission need oxygen supplementation during hospitalization. Overall, among 62 (27.3%) pregnant women 165 (72.7%) postpartum women, 21 (9.2%) received 2 (0.9%) required to...
A large proportion of SARS-CoV-2-infected individuals does not develop severe symptoms. Serological tests help in evaluating the spread infection and disease immunization. The aim this study was to prospectively examine trends risk factors SARS-CoV-2 blood donors.We screened 8798 asymptomatic donors presenting Milan from July 2020 February 2021 (10,680 presentations) before vaccination campaign for anti-nucleoprotein (NP) antibodies, anti-spike receptor-binding domain (RBD) antibodies...
Background: In Italy, healthcare workers (HCWs) were among the first to receive COVID-19 vaccination. Aim of present study is evaluate frequency and severity adverse events (AEs) following second dose BNT162b2 vaccine HCWs a large university hospital in Milan, Italy. Methods: One month after having received vaccine, filled-in form about type, severity, duration post-vaccination local systemic symptoms. We calculated overall AEs used multivariable Poisson regression models (adjusted for sex,...
Urticarial eruptions and angioedema are the most common cutaneous reactions in patients undergoing mRNA COVID-19 vaccinations. The vasoactive peptide bradykinin has long been known to be involved recently also urticaria. Bradykinin is mainly catabolized by angiotensin-converting enzyme (ACE), which inhibited ACE inhibitors, a commonly employed class of antihypertensive drugs. We evaluated risk developing urticaria/angioedema after inoculation with BNT162b2 vaccine population 3586 health care...
Abstract Background The pandemic of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome 2 (SARS-CoV-2), had a significant impact worldwide. Vaccines against COVID-19 appear as tool able to curb out mortality and reduce circulation virus. Little is known so far about clinical characteristics individuals who developed SARS-CoV-2 infection after having received vaccination, well temporal relationship between vaccine administration symptoms onset. Methods...
to evaluate immunogenicity and effectiveness of BNT162b2 COVID-19 vaccine in a cohort healthcare workers (HCWs).cohort study.in hospital Milan (Lombardy Region, Northern Italy) HCWs without ("negative cohort") with ("positive history SARS-CoV-2 infection or elevated serum antibody before the vaccination campaign (27.12.2020) were included. Data collection follow-up covered period 27.12.2020-13.05.2022.1. anti-spike-1 (anti-S1) levels after vaccination; 2. (VE) against infections (either...
since October 2020, a second SARS-CoV-2 epidemic wave has hit Italy. We investigate the frequency of positive nasopharyngeal swabs among HCWs during two waves and association with occupation demographic characteristics.
Coagulopathy and immune dysregulation have been identified as important causes of adverse outcomes in coronavirus disease (COVID-19). Mid-region proadrenomedullin (MR-proADM) is associated with endothelial damage has recently proposed a prognostic factor COVID-19. In non-COVID-19 immunocompromised patients, low vitro interferon gamma (IFNγ) production correlates infection risk mortality. This prospective, monocentric, observational study included adult patients consecutively admitted...
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Abstract Coronavirns disease 2019 is a pandemic viral affecting also obstetric patients and uncertainties exist about the prognostic role of inflammatory biomarkers hemocytometry values in with this infection. To clarify that, we assessed several variables cohort hospitalized coronavirus correlated at admission need oxygen supplementation during hospitalization. Overall, among 27 (61%) pregnant women 17 (39%) post-partum women, 6 (14%) received 2 (4%) required to intensive care unit but none...
The presumptive laboratory diagnosis of <em>Clostridium</em> <em>difficile</em> infection is achieved by the means detection a common antigen (glutamate dehydrogenase, GDH) in stool, then confirming positives either toxins A and B or molecular test for pathogenicity <em>locus</em>, encoding two binary toxin. fully automated chemiluminescence system GDH (LIAISON® C. difficile Toxin B) (DiaSorin, Gerenzano, Italy) allows performance these tests on large...
Aim: To evaluate the gene expression changes that occur soon after active infection of two susceptible cell types with human herpesvirus 8 (HHV-8). Materials & methods: The profile 282 genes involved in inflammatory process was investigated HHV-8 A1 or C3 subtype-infected and mock-infected epithelial cells lymphoid cells. Results: HHV-8-induced transcriptional profiles were very different. A robust increase found belonging to different categories, especially categories inflammation response...