Cillian De Gascun
A5016686237- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- Hepatitis C virus research
- Viral Infections and Immunology Research
- Cytomegalovirus and herpesvirus research
- COVID-19 Clinical Research Studies
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- Animal Virus Infections Studies
- HIV/AIDS drug development and treatment
- SARS-CoV-2 detection and testing
- Hepatitis B Virus Studies
- Virus-based gene therapy research
- Polyomavirus and related diseases
- Vaccine Coverage and Hesitancy
- Herpesvirus Infections and Treatments
- Liver Disease Diagnosis and Treatment
- Influenza Virus Research Studies
- Virology and Viral Diseases
- Parvovirus B19 Infection Studies
- Hepatitis Viruses Studies and Epidemiology
- HIV, Drug Use, Sexual Risk
- HIV-related health complications and treatments
- Antenna Design and Analysis
University College Dublin
2016-2025
National University of Ireland
2016-2025
Health Protection Surveillance Centre
2023
University College Cork
2023
Children's Health Ireland at Crumlin
2023
Hokkaido University
2023
University of Maryland, College Park
2022
Global Virus Network
2022
University of York
2022
Trinity College Dublin
2021
Understanding HIV-1 subtype distribution and epidemiology can assist preventive measures clinical decisions. Sequence variation may affect antiviral drug resistance development, disease progression, evolutionary rates transmission routes. We investigated the of in Europe Israel a representative sample patients diagnosed between 2002 2005 related it to demographic data available. 2793 PRO-RT sequences were subtyped either with REGA Subtyping tool or by manual procedure that included...
We report a rapid increase in enterovirus D68 (EV-D68) infections, with 139 cases reported from eight European countries between 31 July and 14 October 2021. This upsurge is line the seasonality of EV-D68 was presumably stimulated by widespread reopening after COVID-19 lockdown. Most were identified September, but more are to be expected coming months. Reinforcement clinical awareness, diagnostic capacities surveillance urgently needed Europe.
SARS-CoV-2 RNA quantification in wastewater is an important tool for monitoring the prevalence of COVID-19 disease on a community scale which complements case-based surveillance systems. As novel variants concern (VOCs) emerge there also need to identify primary circulating community, accomplished date by sequencing clinical samples. Quantifying offers cost-effective means augment these efforts. In this study, N1 concentrations and daily loadings were determined compared data collected as...
A severe third wave of COVID-19 disease affected Ireland in the first 3 months 2021. In this wave, 1 second-trimester miscarriage and 6 stillbirths were observed Irish population because placental insufficiency as a result SARS-CoV-2 placentitis. This observation was at odds with country's previous experience pregnant mothers.To describe clinical pathologic features these pregnancy losses.Retrospective review data cases miscarriage, stillbirth, or neonatal death identified by perinatal...
Abstract Enterovirus D68 (EV-D68) infections are associated with severe respiratory disease and acute flaccid myelitis (AFM). The European Non-Polio Network (ENPEN) aimed to investigate the epidemiological genetic characteristics of EV-D68 its clinical impact during fall-winter season 2021–2022. From 19 countries, 58 institutes reported 10 481 (6.8%) EV-positive samples which 1004 (9.6%) were identified as (including 852 samples). Clinical data for 969 cases; 78.9% in children (0–5 years);...
Chronic infection with hepatitis B virus and HIV causes significant morbidity mortality. Effective antiviral treatment is available for both. Ireland has historically been considered a low prevalence country. However, increasing inward migration diversity, this may be changing. The aim of study was to measure the community infections in Irish residents born between years 1965 1985. Anonymised residual serum samples from blood tests ordered by general practitioners tested eight hospital...
During April-July 2022, outbreaks of severe acute hepatitis unknown etiology (SAHUE) were reported in 35 countries. Five percent cases required liver transplantation, and 22 patients died. Viral metagenomic studies clinical samples from SAHUE showed a correlation with human adenovirus F type 41 (HAdV-F41) adeno-associated virus 2 (AAV2). To explore the association between those DNA viruses children Ireland, we quantified HAdV-F41 AAV2 collected wastewater treatment plant serving 40%...
Abstract Human adenovirus (HAdV) serotype 14 is rarely identified. However, an emerging variant, termed HAdV-14p1, recently has been described in the United States association with outbreaks of acute respiratory disease high rates illness and death. We retrospectively analyzed specimens confirmed positive for HAdV by immunofluorescence, virus culture, or real-time PCR during July 1, 2009–July 31, 2010, describe 9 cases HAdV-14p1 infection characteristic mutations fiber E1A genes that are...
Human adenovirus (HAdV) serotype 14 is rarely identified. However, an emerging variant, termed HAdV-14p1, recently has been described in the United States association with outbreaks of acute respiratory disease high rates illness and death. We retrospectively analyzed specimens confirmed positive for HAdV by immunofluorescence, virus culture, or real-time PCR during July 1, 2009-July 31, 2010, describe 9 cases HAdV-14p1 infection characteristic mutations fiber E1A genes that are...
In February 2015, an outbreak of recently acquired HIV infections among people who inject drugs (PWID) was identified in Dublin, following similar outbreaks Greece and Romania 2011. We compared drug risk behaviours 15 cases 39 controls. Injecting a synthetic cathinone, snow blow, associated with recent infection (AOR: 49; p=0.003). Prevention control efforts are underway PWID but may also be needed elsewhere Europe.
In 2018, an upsurge in echovirus 30 (E30) infections was reported Europe. We conducted a large-scale epidemiologic and evolutionary study of 1,329 E30 strains collected 22 countries Europe during 2016-2018. Most cases affected persons 0-4 years age (29%) 25-34 (27%). Sequences were divided into 6 genetic clades (G1-G6). (53%) sequences belonged to G1, followed by G6 (23%), G2 (17%), G4 (4%), G3 (0.3%), G5 (0.2%). Each clade encompassed unique individual recombinant forms; G1 displayed >2...
BackgroundMpox, caused by monkeypox virus (MPXV), was considered a rare zoonotic disease before May 2022, when global epidemic of cases in non-endemic countries led to the declaration Public Health Emergency International Concern. Cases mpox Ireland, country without previous reports, could reflect extended local transmission or multiple epidemiological introductions.AimTo elucidate origins and molecular characteristics MPXV circulating Ireland between 2022 October 2023.MethodsWhole genome...
Abstract Background Healthcare workers (HCWs) are at increased risk of SARS-CoV-2 infection. This persists despite the implementation mitigating factors, including vaccination. The ongoing impact incident infection and symptomatic COVID-19 disease in vaccinated HCWs is poorly understood. Aim We aimed to describe epidemiology infections, as well investigating serological, clinical demographic factors associated with developing Design was a multi-centre prospective longitudinal study followed...
An outbreak of severe acute hepatitis unknown aetiology in children (HUAC) was reported by the United Kingdom (UK) spring 2022. Within days, a corresponding increase identified Ireland. A multi-agency incident management team (IMT), led Health Protection Surveillance Centre (HPSC), established national case definition, trawling questionnaire, testing protocol and communications plan. Between 1 October 2021 12 May 2023, 44 probable three possible cases HUAC were Ireland with median age 3...