A5089324012- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Hepatitis C virus research
- Systemic Lupus Erythematosus Research
- Multiple Sclerosis Research Studies
- Reproductive System and Pregnancy
- Psoriasis: Treatment and Pathogenesis
- Hematopoietic Stem Cell Transplantation
- Hepatitis B Virus Studies
- Spaceflight effects on biology
- Animal Virus Infections Studies
- Celiac Disease Research and Management
- Blood groups and transfusion
- Endometriosis Research and Treatment
- Sports Performance and Training
- HIV-related health complications and treatments
- Orthopaedic implants and arthroplasty
- COVID-19 Clinical Research Studies
- Monoclonal and Polyclonal Antibodies Research
- HIV/AIDS drug development and treatment
- IL-33, ST2, and ILC Pathways
- Platelet Disorders and Treatments
- Cytokine Signaling Pathways and Interactions
- Influenza Virus Research Studies
- Viral gastroenteritis research and epidemiology
Irish Blood Transfusion Service
2004-2025
St. Vincent's University Hospital
2010
University College Dublin
2010
Johnson Space Center
2004-2007
The role of cytotoxic T lymphocyte responses, restricted by human leukocyte antigen (HLA) class I alleles, is recognized as highly significant in the successful clearance hepatitis C virus (HCV). frequency alleles females inoculated with HCV genotype 1b from a single source was examined for an association outcome. Class typing performed using polymerase chain reaction sequence-specific primers 227 female subjects: 141 had chronic infection and 86 viral clearance. Statistical analysis...
Hepatitis C is a common infection with significant morbidity and mortality, only minority of patients successfully clear the infection. Identification factors that influence disease progression in HCV difficult owing to lack well-defined patient cohorts. However, recent evidence supports role for innate immune system virus clearance. In this study, we investigated genes their contribution unique cohort well-controlled HCV-infected patients. The Irish uniquely homogenous; were infected single...
The relationship between prevalence of multiple sclerosis (MS) and latitude may be due to both genetic environmental factors. hypothesis that, in Ireland, MS is increasing that north-south differences relate variation serum 25-hydroxyvitamin D (25(OH)D) levels was tested this study.Patients matched control subjects were identified counties Donegal, Wexford South Dublin through sources. Prevalence determined. Blood samples taken for 25(OH)D intact parathyroid hormone measurement, DNA...
Anti-tumour necrosis factor (TNF)-α therapies have revolutionized the treatment of psoriasis; however, up to 50% patients do not respond satisfactorily. Identification pharmacogenetic markers response is an important stop in development individually tailored treatment. The objective this study was assess association human leucocyte antigen (HLA)-C, killer immunoglobulin receptor (KIR) and vitamin D (VDR) genotypes with by etanercept adalimumab.This a 138 severe chronic plaque psoriasis who...
An outbreak of severe acute hepatitis unknown aetiology in children (HUAC) was reported by the United Kingdom (UK) spring 2022. Within days, a corresponding increase identified Ireland. A multi-agency incident management team (IMT), led Health Protection Surveillance Centre (HPSC), established national case definition, trawling questionnaire, testing protocol and communications plan. Between 1 October 2021 12 May 2023, 44 probable three possible cases HUAC were Ireland with median age 3...
The frequencies of human leucocyte antigen (HLA) class I and II alleles haplotypes 250 Irish unrelated bone marrow donors were determined by high resolution polymerase chain reaction (PCR), using a combination reverse line blot hybridization PCR with sequence-specific primers. Phylogenetic analyses indicate that this population is closely related to British, North-western European, American Australian Caucasian populations. These observations are consistent recognized historical,...
Aims Hip resurfacing remains a potentially valuable surgical procedure for appropriately-selected patients with optimised implant choices. However, concern regarding high early failure rates continues to undermine confidence in use. A large contributor is adverse local tissue reactions around metal-on-metal (MoM) bearing surfaces. Such phenomena have been well-explored MoM total hip arthroplasties, but comparable data equivalent procedures lacking. In order define genetic predisposition, we...
Background Hepatitis C virus infection is a major cause of nonA, nonB hepatitis worldwide. A high prevalence immunological abnormalities has been shown to occur in patients with chronic infection. Aim The aim this study was assess the development sicca syndrome cohort infected single strain virus, namely genotype 1b, and correlate viral persistence human leukocyte antigen type patients. Methods Ninety-five were used study, 32 whom polymerase chain reaction-negative 63 reaction-positive....
The contribution of human leucocyte antigen (HLA) to the genetic risk for multiple sclerosis (MS) in patients Northern European Caucasoid ancestry has been known since 1970s. northern part Ireland, including county Donegal, is be a high-risk area development MS. Recorded prevalence rates Wexford south-east Ireland have markedly lower and suggest existence gradient within island. To evaluate association HLA-DRB1 -DQB1 haplotypes with MS both we examined total 118 400 regionally matched...
SUMMARY Background HLAMatchmaker has been used in the Irish Blood Transfusion Service ( IBTS ) to select platelets for HLA ‐alloimmunised, platelet refractory thrombocytopaenic patients since 2006. Although available 2002, only three studies have published supporting programme's effectiveness this indication. Objectives We sought examine increments ‐matched HMPs at various matchmaker scores and impact of transfusing older ABO ‐mismatched patient group. Methods/Materials A total 20...
Abstract: We report the definition of an HLA class I null allele that has been identified within B35 group by a combination serological and molecular typing. This allele, which named B*3540N, was detected in French, potential unrelated hematopoietic stem cell donor unknown ethnic origin, selected as probable match for Irish patient. The presence initially determined absence reactivity typing, contrast to positive reactions PCR‐SSP PCR‐SSO Subsequent sequencing clones containing full genomic...
Abstract The recent pandemic was caused by the emergence of a new human pathogen, SARS-CoV-2. While rapid development many vaccines provided an end to immediate crisis, there remains urgent need understand more about this virus and what constitutes beneficial immune response in terms successful resolution infection. Indeed, is key for that provide long lasting protective immunity. interferon lambda (IFNL) family cytokines are produced early infection generally considered anti-viral...
HLA class II typing by sequence specific oligonucleotide probes (SSOP) on the family of a Burkit's Lymphoma patient produced hybridization patterns indicating presence two DRB1, and linked DQB1 genes same maternal chromosome. DRB exon 2 amplification products associated with novel haplotype were identified DNA techniques: These corresponded to DRB1*0101, DRB1*1501, DRB5*01, DQB1*0501 DQB1*0602 alleles. alleles seen co-segregate among siblings sharing haplotype. The patient, his mother each...
Background: Trends have recently been observed suggesting more rapid progression in newly-diagnosed HIV-positive patients. This data is limited by an inability to specifically identify the time of infection. Our cohort displays heterogenous acquisition risk and significant immigration from countries high prevalence, ideal study changing epidemiology. Methods: A retrospective was undertaken comparing newly diagnosed HIV patients attending first half 2004 with those 2008. Baseline demographics...
1833 INRODUCTION: Exercise countermeasures during long duration space flight have historically employed treadmill and cycle exercises with little or no resistive component. On the Russian Mir Space Station, crewmembers performed exercise bungee cords (max resistance: 40 kg). An interim device (iRED; max 135 kg) was deployed for use by on International Station (ISS) to compliment aerobic exercise. Due operational hardware constraints, iRED has not been used extent originally planned. The...
<h3>Introduction</h3> Reports suggest increasing multiple sclerosis (MS) prevalence, which distinctively rises with latitude. Genetic factors contribute but vitamin D deficiency is a possible co-factor. <h3>Hypotheses</h3> In Ireland, lower in MS patients than controls. Greater prevalence at higher latitudes corresponds to levels. Prevalence greater 2001. <h3>Patients and Methods</h3> Patients controls Donegal, Wexford South Dublin attended research clinics from November 2007 March 2008....
1833 INRODUCTION: Exercise countermeasures during long duration space flight have historically employed treadmill and cycle exercises with little or no resistive component. On the Russian Mir Space Station, crewmembers performed exercise bungee cords (max resistance: 40 kg). An interim device (iRED; max 135 kg) was deployed for use by on International Station (ISS) to compliment aerobic exercise. Due operational hardware constraints, iRED has not been used extent originally planned. The...