A5006048374- COVID-19 Clinical Research Studies
- Obesity, Physical Activity, Diet
- Birth, Development, and Health
- Frailty in Older Adults
- Nutrition and Health in Aging
- Health Systems, Economic Evaluations, Quality of Life
- Cancer survivorship and care
- Language Development and Disorders
- Health disparities and outcomes
- Meta-analysis and systematic reviews
- SARS-CoV-2 and COVID-19 Research
- Balance, Gait, and Falls Prevention
- Long-Term Effects of COVID-19
- Advanced Causal Inference Techniques
- Gestational Diabetes Research and Management
- Child Nutrition and Water Access
- Pharmaceutical Practices and Patient Outcomes
- Nutritional Studies and Diet
- SARS-CoV-2 detection and testing
- Male Reproductive Health Studies
- Family and Disability Support Research
- Testicular diseases and treatments
- COVID-19 and healthcare impacts
- Breastfeeding Practices and Influences
- Iron Metabolism and Disorders
University College Cork
2016-2025
Health Research Board
2017-2025
Cork University Hospital
2019-2025
University Hospital Waterford
2024-2025
Google (United States)
2024
University College Dublin
2023
Hokkaido University
2023
Health Protection Surveillance Centre
2023
Children's Health Ireland at Crumlin
2023
Institute of Public Health
2023
To investigate associations between adverse childhood experiences (ACEs) and later-life depressive symptoms; to explore whether perceived social support (PSS) moderates these.We analysed baseline data from the Mitchelstown (Ireland) 2010-2011 cohort of 2047 men women aged 50-69 years. Self-reported measures included ACEs (Centre for Disease Control ACE questionnaire), PSS (Oslo Social Support Scale) symptoms (CES-D). The primary exposure was self-report at least one ACE. We also investigated...
Background: Promoting catch-up growth in malnourished children has health benefits, but recent evidence suggests that accelerated child weight gain increases adult chronic disease risk. Objective: We aimed to determine how birth (BW) and midchildhood relate blood pressure (BP) young adults. Design: pooled data from cohorts Brazil, Guatemala, India, the Philippines, South Africa. used conditional (CW), a residual of current regressed on prior weights, represent deviations expected 0 12, 12...
Multi-morbidity and polypharmacy increase the risk of non-trivial adverse drug reactions (ADRs) in older people during hospitalization. Despite this, there are no established interventions for hospital-acquired ADR prevention.We undertook a pragmatic, multi-national, parallel arm prospective randomized open-label, blinded endpoint (PROBE) controlled trial enrolling patients at six European medical centres. We 1,537 surgical with multi-morbidity on admission 1:1 ratio to SENATOR...
SARS-CoV-2 RNA quantification in wastewater is an important tool for monitoring the prevalence of COVID-19 disease on a community scale which complements case-based surveillance systems. As novel variants concern (VOCs) emerge there also need to identify primary circulating community, accomplished date by sequencing clinical samples. Quantifying offers cost-effective means augment these efforts. In this study, N1 concentrations and daily loadings were determined compared data collected as...
During April-July 2022, outbreaks of severe acute hepatitis unknown etiology (SAHUE) were reported in 35 countries. Five percent cases required liver transplantation, and 22 patients died. Viral metagenomic studies clinical samples from SAHUE showed a correlation with human adenovirus F type 41 (HAdV-F41) adeno-associated virus 2 (AAV2). To explore the association between those DNA viruses children Ireland, we quantified HAdV-F41 AAV2 collected wastewater treatment plant serving 40%...
Abstract Objective To evaluate the efficacy and safety of non‐ablative vaginal Er:YAG laser device in stress urinary incontinence (SUI) treatment. Methods We conducted a multicenter blinded randomized sham‐controlled trial which women with urodynamic SUI were randomization to active arm using therapy, sham handpiece. Patients received two treatments 1 month apart. The primary outcomes measure was h pad weight test measured at 6 months. Secondary durability treatment success 12 months,...
Data-driven approaches to dietary patterns are under-utilized; latent class analyses (LCA) particularly rare. The present study used an LCA identify subgroups of people with similar patterns, explore changes in over a 10-year period and relate these dynamics sociodemographic factors health outcomes.The 1998 baseline 2008 follow-up the Cork Kerry Diabetes Heart Disease Study. Diets were assessed standard FFQ. LCA, under assumption conditional independence, was mutually exclusive different...
Evidence suggests that inactivity during a hospital stay is associated with poor health outcomes in older medical inpatients. We aimed to estimate the associations of average daily step-count (walking) physical performance and length this population.
Objectives Fever is a common symptom of mostly benign illness in young children, yet concerning for parents. The aim this study was to describe parental knowledge, attitudes and beliefs regarding fever children aged ≤5 years age. Design A cross-sectional using previously validated questionnaire. Results were analysed descriptive statistics multivariable logistic regression. Setting Purposively selected primary schools (n=8) Cork, Ireland, paper-based Data collected from internet-based...
Abstract Background To measure the effects of an augmented prescribed exercise programme versus usual care, on physical performance, quality life and healthcare utilisation for frail older medical patients in acute setting. Methods This was a parallel single-blinded randomised controlled trial. Within 2 days admission, inpatients with anticipated length stay ≥3 days, needing assistance/aid to walk, were blindly randomly allocated intervention or control group. Until discharge, both groups...
The aim of this trial is to evaluate the effect SENATOR software on incident, adverse drug reactions (ADRs) in older, multimorbid, hospitalized patients. produces a report designed optimize older patients’ current prescriptions by applying published STOPP and START criteria, highlighting drug-drug drug-disease interactions providing non-pharmacological recommendations aimed at reducing risk incident delirium. We will conduct multinational, pragmatic, parallel arm Prospective Randomized...
In the intravenous iron therapy to treat deficiency anaemia in patients undergoing major abdominal surgery (PREVENTT) trial, use of did not reduce need for blood transfusion or patient complications length hospital stay. As part trial protocol, serum was collected at randomisation and on day surgery. These samples were analysed a central laboratory markers deficiency. We performed secondary analysis explore potential interactions between pre-operative intervention status outcome measures....
<ns3:p>Background In areas of social disadvantage up to 40–50% children enter preschool with speech and language skills significantly poorer than would be expected for their age. The Happy Talk trial tests if a community embedded, targeted selective programme that simultaneously engages parents early childhood educators, (1) improves outcomes in aged between 2 years 10 months 6 (2) is cost effective the health care system. Method large scale cluster randomised 12-week manualised intervention...
This study explores the incidence of preoperative hypophosphatemia and whether may have affected patient or trial outcomes for those who received ferric carboxymaltose.