Giovanni Guaraldi
A5006204124- HIV-related health complications and treatments
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- COVID-19 Clinical Research Studies
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Pneumocystis jirovecii pneumonia detection and treatment
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Nutrition and Health in Aging
- Frailty in Older Adults
- Bone and Joint Diseases
- Cytomegalovirus and herpesvirus research
- Liver Disease and Transplantation
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes and associated disorders
- Dermatological and COVID-19 studies
- Cardiovascular Disease and Adiposity
- Renal Transplantation Outcomes and Treatments
- Hormonal and reproductive studies
- Lipoproteins and Cardiovascular Health
- Vitamin D Research Studies
- Hepatitis B Virus Studies
- COVID-19 and healthcare impacts
University of Modena and Reggio Emilia
2016-2025
Azienda Ospedaliero-Universitaria di Modena
2016-2025
GTx (United States)
2017-2024
Morpho (United States)
2021-2024
University of Colorado Anschutz Medical Campus
2023
May Institute
2023
University Hospital of Bern
2023
Hyundai Mobis (South Korea)
2023
Azienda Sanitaria Unità Locale di Reggio Emilia
2020-2021
Ysbyty Ystrad Fawr
2021
(See the Editorial Commentary by Capeau, on pages 1127–9.) Background. Human immunodeficiency virus (HIV)–infected patients may have a greater risk of noninfectious comorbidities (NICMs) compared with general population. We assessed prevalence and factors for NICMs in large cohort HIV-infected adults these findings data from matched control subjects. Methods. performed case-control study involving antiretroviral therapy (ART)–experienced treated at Modena University, Italy, 2002 through...
Abstract The immune system of patients infected by SARS-CoV-2 is severely impaired. Detailed investigation T cells and cytokine production in affected COVID-19 pneumonia are urgently required. Here we show that, compared with healthy controls, patients’ cell compartment displays several alterations involving naïve, central memory, effector memory terminally differentiated cells, as well regulatory PD1 + CD57 exhausted cells. Significant exist also lineage-specifying transcription factors...
The severe acute respiratory syndrome-coronavirus 2 outbreak spread rapidly in Italy and the lack of intensive care unit (ICU) beds soon became evident, forcing application noninvasive support (NRS) outside ICU, raising concerns over staff contamination. We aimed to analyse safety hospital feasibility outcomes NRS applied patients ICU.In this observational study, data from 670 consecutive with confirmed coronavirus disease 2019 referred pulmonology units nine hospitals between March 1 May...
In patients infected by SARS-CoV-2 who experience an exaggerated inflammation leading to pneumonia, monocytes likely play a major role but have received poor attention. Thus, we analyzed peripheral blood from with COVID-19 pneumonia and found that these cells show signs of altered bioenergetics mitochondrial dysfunction, had reduced basal maximal respiration, spare respiratory capacity, decreased proton leak. Basal extracellular acidification rate was also diminished, suggesting capability...
Abstract Background C-reactive protein (CRP) is a non-specific acute phase reactant elevated in infection or inflammation. Higher levels indicate more severe and have been used as an indicator of COVID-19 disease severity. However, the evidence for CRP prognostic marker yet to be determined. The aim this study examine response patients hospitalized with determine utility on admission predicting inpatient mortality. Methods Data were collected between 27 February 10 June 2020, incorporating...
<h3>Objective:</h3> To establish whether HIV disease is associated with abnormal levels of age-related brain atrophy, by estimating apparent age using neuroimaging and exploring these estimates related to status, age, cognitive performance, HIV-related clinical parameters. <h3>Methods:</h3> A large sample virologically suppressed HIV-positive adults (n = 162, 45–82 years) highly comparable HIV-negative controls 105) were recruited as part the Comorbidity in Relation AIDS (COBRA)...
Background The European AIDS Clinical Society (EACS) Guidelines cover key aspects of HIV management with major updates every two years. Guideline highlights 2019 were extended a new section focusing on drug–drug interactions and other prescribing issues in people living (PLWH). recommendations for treatment‐naïve PLWH updated four preferred regimens favouring unboosted integrase inhibitors. A two‐drug regimen dolutegravir lamivudine, three‐drug including doravirine also added to the...
The COVID-19 pandemic caused by SARS-CoV-2 is a continuous challenge worldwide, and there an urgent need to map the landscape of immunogenic immunodominant epitopes recognized CD8+ T cells. Here, we analyze samples from 31 patients with for cell recognition 500 peptide-HLA class I complexes, restricted 10 common HLA alleles. We identify 18 epitopes, including epitope features derived ORF1ab HLA-A*01:01. In-depth characterization SARS-CoV-2-specific responses acute critical severe disease...
Abstract Background The European AIDS Clinical Society (EACS) guidelines were revised in 2023 for the 19th time, and all aspects of HIV care updated. Key Points Guidelines Update Version 12.0 recommend same six first‐line treatment options antiretroviral (ART)‐naïve adults as versions 11.0 11.1: tenofovir‐based backbone plus an unboosted integrase inhibitor or doravirine; abacavir/lamivudine dolutegravir; dual therapy with lamivudine emtricitabine dolutegravir. long‐acting section has been...
Abstract Background The European AIDS Clinical Society (EACS) Guidelines were revised in 2021 for the 17th time with updates on all aspects of HIV care. Key points update Version 11.0 recommend six first‐line treatment options antiretroviral (ART)‐naïve adults: tenofovir‐based backbone plus an unboosted integrase inhibitor or doravirine; abacavir/lamivudine dolutegravir; dual therapy lamivudine emtricitabine dolutegravir. Recommendations preferred and alternative combinations from birth to...
The prevalence and predictors of nonalcoholic fatty liver disease (NAFLD) in human immunodeficiency virus (HIV)-infected highly active antiretroviral therapy-experienced patients the association NAFLD with risk cardiovascular subclinical atherosclerosis are unknown.We performed a cross-sectional observational study. was defined by liver-spleen attenuation values <1.1 on computed tomography persons who had neither evidence chronic viral hepatitis nor significant history alcohol consumption.We...
Background Metabolic diseases are frequently observed in HIV‐infected persons and, as the risk of contracting these is age‐related, their prevalence will increase future a consequence benefits antiretroviral therapy (ART). Summary guidelines All should be screened at regular intervals for history metabolic disease, dyslipidaemia, diabetes mellitus, hypertension and alteration body composition; cardiovascular renal function also assessed. Efforts to prevent disease vary intensity depending on...
Thirty-four human immunodeficiency virus (HIV) specialists from 16 countries contributed to this project, whose primary aim was provide guidance on the screening, diagnosis, and monitoring of bone disease in HIV-infected patients. Four clinically important questions management were identified, recommendations, based literature review expert opinion, agreed upon. Risk fragility fracture should be assessed primarily using Fracture Assessment Tool (FRAX), without dual-energy X-ray...
Objectives: Aging with HIV is associated multisystem vulnerability that might be well characterized by frailty. We sought to construct a frailty index based on health deficit accumulation in large clinical cohort and evaluate its validity including the ability predict mortality incident multimorbidity. Design methods: This an analysis of data from prospective Modena Metabolic Clinic cohort, 2004–2014. Routine variables were screened for potential inclusion index. Content, construct,...
Geriatric Patients Living with HIV/AIDS (GEPPO) is a new prospective observational multicentre cohort consisting of all the HIV-positive geriatric patients being treated at 10 clinics in Italy, and HIV-negative controls attending single clinic. The aim this analysis GEPPO was to compare prevalence risk factors individual non-communicable diseases (NCD), multi-morbidity (MM) polypharmacy (PP) amongst HIV positive negative enrolment into cohort. This cross-sectional study conducted between...
The increasing life spans of people infected with human immunodeficiency virus (HIV) reflect enormous treatment successes and present new challenges related to aging. Even suppression viral loads immune reconstitution, HIV-positive individuals exhibit excess vulnerability multiple health problems that are not AIDS-defining. With the accumulation problems, it is likely many aging treated HIV infection may be identified as frail. Studies frailty in currently limited but suggest might feasible...