Giustino Parruti
A5074984739- Hepatitis C virus research
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- HIV/AIDS Research and Interventions
- HIV-related health complications and treatments
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Antibiotic Resistance in Bacteria
- SARS-CoV-2 and COVID-19 Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Systemic Lupus Erythematosus Research
- Sepsis Diagnosis and Treatment
- Antibiotic Use and Resistance
- Cytomegalovirus and herpesvirus research
- Parvovirus B19 Infection Studies
- Antibiotics Pharmacokinetics and Efficacy
- Receptor Mechanisms and Signaling
- Nosocomial Infections in ICU
- Liver Disease and Transplantation
- Pneumonia and Respiratory Infections
- Herpesvirus Infections and Treatments
- Chronic Lymphocytic Leukemia Research
- Respiratory Support and Mechanisms
Azienda USL di Pescara
2016-2025
Ospedale di Santo Spirito
2012-2024
University of Bologna
2023
University of Teramo
2023
Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise G. Caporale
2023
ASL Roma
2020-2022
University of Sassari
2016-2021
University of Rome Tor Vergata
2020
Presidio Ospedaliero
2020
Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani
2016-2019
Ceftazidime-avibactam (CAZ-AVI) has been approved in Europe for the treatment of complicated intra-abdominal and urinary tract infections, as well hospital-acquired pneumonia, gram-negative infections with limited options. CAZ-AVI displays vitro activity against Klebsiella pneumoniae carbapenemase (KPC) enzyme producers, but clinical trial data on its efficacy this setting are lacking.We retrospectively reviewed 138 cases caused by KPC-producing K. (KPC-Kp) adults who received...
The beta-adrenergic receptor system of the failing human heart is markedly desensitized. We have recently postulated that this desensitization may in part be caused by an increase kinase (beta ARK) expression. beta ARK thought to effect acting concert with inhibitor protein, called beta-arrestin. Two isoforms been identified both for and In present study, we investigated expression individual beta-arrestin left ventricles from control hearts. mRNAs all four proteins, beta-arrestin-1,...
Methods. Case patients were 32 congenitally infected children aged 1–5 years who had either hearing deficit and/or psychomotor retardation and whose mothers a confirmed or probable primary CMV infection at ≤20 weeks' gestation. Control subjects normal control matched by the weeks of maternal gestation (±1 week) mother's child's age year) evaluation.
Abstract Introduction A hypercoagulable condition was described in patients with coronavirus disease 2019 (COVID-19) and proposed as a possible pathogenic mechanism contributing to progression lethality. Aim We evaluated if in-hospital administration of heparin improved survival large cohort Italian COVID-19 patients. Methods In retrospective observational study, 2,574 unselected hospitalized 30 clinical centers Italy from February 19, 2020 June 5, laboratory-confirmed severe acute...
This retrospective case-control study was aimed at identifying potential independent predictors of severe/lethal COVID-19, including the treatment with Angiotensin-Converting Enzyme inhibitors (ACEi) and/or Angiotensin II Receptor Blockers (ARBs).All adults SARS-CoV-2 infection in two Italian provinces were followed for a median 24 days. ARBs ACEi treatments, and hypertension, diabetes, cancer, COPD, renal major cardiovascular diseases (CVD) extracted from clinical charts electronic health...
We carried out a prospective observational study to evaluate whether Monocyte Distribution Width (MDW) may play role in identifying patients with sepsis comparison Procalcitonin (PCT). prospectively enrolled all consecutive hospitalized at the Infectious Diseases Unit of Pescara General Hospital for bacterial infection or sepsis. MDW values were collected patients. Clinical characteristics, demographic data, past and present medical history, microbiological results, PCT, as well neutrophil...
Receptor phosphorylation is a key step in the process of desensitization beta-adrenergic and other related receptors. A selective kinase (called receptor kinase, beta ARK) has been identified which phosphorylates agonist-occupied form receptor. Recently bovine ARK cDNA cloned highest levels specific mRNA were found highly innervated tissues. It was proposed that may be primarily active on synaptic In present study, human sequenced. The sequence very similar to (the overall amino acid...
Abstract Background & Aims Despite the excellent efficacy of direct‐acting antivirals ( DAA ) reported in clinical trials, virological failures can occur, often associated with development resistance‐associated substitutions RAS s). This study aimed to characterize presence clinically relevant s all classes real‐life failures. Methods Of 200 that were analyzed 197 ‐treated patients, 89 pegylated‐interferon+ribavirin (Peg IFN + RBV and 111 without HCV ‐1a/1b/1g/2/3/4=58/83/1/6/24/25;...
Abstract Weight gain and body mass index (BMI) increase are central issues in patients living with HIV who need to minimize the risk of metabolic disease. Information collected through SCOLTA cohort revealed significant 1-year BMI treated dolutegravir (P = .004), raltegravir .0004), elvitegravir darunavir .0006), rilpivirine .029). correlated low baseline .002) older age .0007) Centers for Disease Control Prevention stages A/B, lower .005) CD4+ T-cell count .007) at enrollment stage C.
Background: It is unclear whether lack of immunological response despite viral suppression and relatively preserved CD4+ T-cell count associated with increased risk AIDS or severe non-AIDS events. Methods: Patients initiating first combination antiretroviral therapy (cART) were studied from load 80 copies/ml less up to AIDS, serious events (malignancies, infections, acute kidney injury, cardiovascular events, liver decompensation) death. Follow-up was right censored if more than 500....
We aimed to assess the prevalence of hypertension in an unselected human immunodeficiency virus (HIV)–infected population and identify factors associated with prevalence, treatment, control. used a multicenter, cross-sectional, nationwide study that sampled 1,182 unselected, consecutive, HIV-infected patients. Office blood pressure was accurately measured standard procedures. Patients were 71% men 92% white, median age 47 years (range = 18–78); 6% antiretroviral treatment naive. The overall...
Abstract Background Dual therapy (DT) with boosted protease inhibitors (bPIs) plus lamivudine has been shown to be superior bPI monotherapy in virologically suppressed patients despite previous selection of the resistance M184V mutation. We compared virological efficacy lamivudine-based DT and without a history detection. Methods retrospectively analyzed HIV-RNA ≤50 copies/mL switching at least 1 genotype ARCA database. Time failure (VF; ≥200 or 2 consecutive >50 copies/mL) treatment...
Abstract Background Few data are reported in the literature about outcome of patients with severe extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E) infections treated ceftolozane/tazobactam (C/T), empiric or definitive therapy. Methods A multicenter retrospective study was performed Italy (June 2016–June 2019). Successful clinical defined as complete resolution signs/symptoms related to ESBL-E infection and lack microbiological evidence infection. The primary end point...
•An international cohort of 3,355 patients with hepatitis C from 22 countries was evaluated for drug resistance following DAA therapy.•Nearly all harbored drug-resistant variants after treatment failure, over 2/3 having against ≥2 classes.•Pathways to included enrichment highly resistant and selection multiple variants.•Previously unrecognized in who failed NS5A inhibitors were identified at high frequencies.•Resistance frequent older people cirrhosis those infected genotypes 1b 4 failure....
Two Alternatively Spliced Forms of 0-Arrestin-1 and Arrestin expression function (5, 11).In these cells, we found that mRNA kinase activity PARK-1 a n d PARK-
Beta-adrenergic receptor kinase (beta ARK) is a serine-threonine involved in the process of homologous desensitization G-coupled receptors. beta ARK member multigene family, consisting six known subtypes, also named G protein-coupled kinases (GRK 1-6). In this study we investigated expression GRKs during T cell activation, which fundamental importance regulating immune responses. activation was induced by exposing mononuclear leukocytes (MNL) to PHA and confirmed tritiated thymidine...
Herpes zoster (HZ) is a common disease, characterized by rash-associated localized pain. Its main complication, post-herpetic neuralgia (PHN), difficult to treat and may last for months years in the wake of rash resolution. Uncertainties remain as knowledge predictors HZ-related pain, including role antiviral therapy preventing PHN ordinary clinical practice. This prospective cohort study was aimed at investigating pain intensity HZ presentation its correlates, well incidence predictors....
A total of 43 A. baumannii strains, isolated from patients affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and bacterial sepsis, were analyzed antimicrobial susceptibility testing. All strains resistant to almost three different classes antibiotics, including carbapenems colistin. The whole-genome sequencing (WGS) eight selected isolates showed the presence insertion sequences (ISs), such as ISAba13, ISAba26, IS26, ISVsa3, ISEc29, IS6100 IS17, giving a high ability...