A5033997166- Mosquito-borne diseases and control
- Malaria Research and Control
- Viral Infections and Vectors
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Leptospirosis research and findings
- Travel-related health issues
- Venomous Animal Envenomation and Studies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Liver Disease Diagnosis and Treatment
- Vector-borne infectious diseases
- Parasites and Host Interactions
- Rabies epidemiology and control
- Vibrio bacteria research studies
- HIV/AIDS Research and Interventions
- Adolescent Sexual and Reproductive Health
- Bacteriophages and microbial interactions
- COVID-19 epidemiological studies
- Viral Infections and Outbreaks Research
- Drug-Induced Hepatotoxicity and Protection
- Mental Health Treatment and Access
- Sepsis Diagnosis and Treatment
- HIV/AIDS drug development and treatment
- Monoclonal and Polyclonal Antibodies Research
UNSW Sydney
2016-2025
The University of Sydney
2021-2023
Australian Centre for HIV and Hepatitis Virology Research
2021
University of Colombo
2010-2020
National Hospital of Sri Lanka
2009-2020
University of North Carolina at Chapel Hill
2020
New York University
2020
University College London
2010
The challenge of imparting a large amount knowledge within limited time period in way it is retained, remembered and effectively interpreted by student considerable. This has resulted crucial changes the field medical education, with shift from didactic teacher centered subject based teaching to use interactive, problem based, learning. study tested hypothesis that learning styles (visual, auditory, read/write kinesthetic) approaches (deep, strategic superficial) differ among first final...
Considerable concerns relating to the duration of protective immunity against severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) exist, with evidence antibody titers declining rapidly after infection and reports reinfection. Here, we monitor responses SARS-CoV-2 receptor-binding domain (RBD) for up 6 months infection. While are maintained, ∼13% cohort's neutralizing return background. However, encouragingly, in a selected subset 13 participants, 12 have detectable RBD-specific...
Understanding the long-term maintenance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunity is critical for predicting protection against reinfection. In an age- and gender-matched cohort 24 participants, association disease severity early immune responses on humoral 12 months post-infection examined. All severely affected participants maintain a stable subset SARS-CoV-2 receptor-binding domain (RBD)-specific memory B cells (MBCs) good neutralizing antibody breadth...
The endemic area for dengue fever extends over 60 countries, and approximately 2.5 billion people are at risk of infection. incidence has multiplied many times the last five decades an alarming rate. In areas, waves infection occur in epidemics, with thousands individuals affected, creating a huge burden on limited resources country's health care system. While illness passes off as simple febrile episode many, few have severe marked by hypovolemic shock bleeding. Iatrogenic fluid overload...
Hepatitis C virus (HCV) is a rapidly evolving RNA that has been classified into seven genotypes. All HCV genotypes cause chronic hepatitis, which ultimately leads to liver diseases such as cirrhosis. The are unevenly distributed across the globe, with 1 and 3 being most prevalent. Until recently, molecular epidemiological studies of evolution within host at population level have limited analyses partial viral genome segments, it technically challenging amplify sequence full-length 9.6 kb...
Abstract In 2017, a dengue epidemic of unexpected magnitude occurred in Sri Lanka. A total 186,101 suspected cases and 440 dengue-related deaths occurred. We conducted comprehensive analysis this by comparing national surveillance data for 2017 with from the preceding 5 years. all Lanka districts, incidence increased significantly over during previous Older schoolchildren young adults were more clinically symptomatic than those at extremes age. Limited virologic showed dominant circulating...
•An international cohort of 3,355 patients with hepatitis C from 22 countries was evaluated for drug resistance following DAA therapy.•Nearly all harbored drug-resistant variants after treatment failure, over 2/3 having against ≥2 classes.•Pathways to included enrichment highly resistant and selection multiple variants.•Previously unrecognized in who failed NS5A inhibitors were identified at high frequencies.•Resistance frequent older people cirrhosis those infected genotypes 1b 4 failure....
Abstract Copper sulphate ingestion (accidental or deliberate) is a rare form of poisoning usually limited to the Indian subcontinent. Though rates are on decline, it essential that physicians aware its lethal complications and management strategies. The main copper include intravascular haemolysis, methaemoglobinaemia, acute kidney injury rhabdomyolysis. dose can be as small 10 grams. We have explored with examples from two case presentations. also recommend measures for prevention such events.
Pathogenesis of disease severity in leptospirosis is not clearly understood whether it due to direct damage by pathogen or adverse immune responses. Knowledge on biomarkers oxidative stress which could be used identifying patients with severe illness has shown great value management. Thus, the main aim this study was assess serum proteins and lipids, their significance as leptospirosis. In regions endemic for both dengue, cases are often misdiagnosed dengue during epidemics. Therefore,...
This review examines the interactions of financial status and HIV its implications for women. MEDLINE Google scholar were searched using keywords 'women', 'poverty' 'HIV' in any field article. The search was limited to articles published English over last 10 years. first section article tries establish whether poverty or wealth is a risk factor HIV. There credible evidence both arguments. While shows an increased sexes, places women at special disadvantage. second explains how interacts with...
Breast cancer is the commonest in women worldwide. Although programmes promoting breast awareness are being carried out throughout Sri Lanka, few have targeted school students. We conducted this study to assess knowledge, attitudes and practices regarding with reference screening, services available, self-examination, sources of information, among adolescent schoolgirls Colombo District Lanka.The related were assessed 859 girls schools within District, using a self-administered...