Soo Aleman
A5043318824- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Immune Cell Function and Interaction
- Liver Disease and Transplantation
- Long-Term Effects of COVID-19
- HIV/AIDS drug development and treatment
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- CAR-T cell therapy research
- HIV Research and Treatment
- Immunodeficiency and Autoimmune Disorders
- Chronic Lymphocytic Leukemia Research
- Hepatitis Viruses Studies and Epidemiology
- Immune responses and vaccinations
- HIV, Drug Use, Sexual Risk
- Gut microbiota and health
- SARS-CoV-2 detection and testing
- HIV/AIDS Research and Interventions
- Viral Infections and Immunology Research
- COVID-19 and Mental Health
- Phagocytosis and Immune Regulation
- Dermatological and COVID-19 studies
Karolinska Institutet
2016-2025
Karolinska University Hospital
2016-2025
Louisiana State University
2023-2024
Louisiana State University Health Sciences Center New Orleans
2023-2024
Svenska Örtmedicinska Institute
2017-2023
Universidad Tecnológica del Perú
2023
University of Pisa
2023
Center for Disease Analysis
2022
Creative Commons
2022
Evidence (Italy)
2021
Summary The disease burden of hepatitis C virus ( HCV ) is expected to increase as the infected population ages. A modelling approach was used estimate total number viremic infections, diagnosed, treated and new infections in 2013. In addition, model change progression mortality 2013–2030. Finally, expert panel consensus capture current treatment practices each country. Using today's paradigm, projected decline or remain flat all countries studied. However, same time period, individuals with...
Understanding innate immune responses in COVID-19 is important to decipher mechanisms of host and interpret disease pathogenesis. Natural killer (NK) cells are effector lymphocytes that respond acute viral infections but might also contribute immunopathology. Using 28-color flow cytometry, we here reveal strong NK cell activation across distinct subsets peripheral blood patients. This pattern was mirrored scRNA-seq signatures bronchoalveolar lavage from Unsupervised high-dimensional analysis...
Abstract The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron (B.1.1.529) variant concern (VOC) has destabilized global efforts to control impact disease 2019 (COVID-19). Recent data have suggested that B.1.1.529 can readily infect people with naturally acquired or vaccine-induced immunity, facilitated in some cases by viral escape from antibodies neutralize ancestral SARS-CoV-2. However, appears be relatively uncommon such individuals, highlighting a...
More information is needed about the long-term effects of low-dose aspirin (≤160 mg) on incident hepatocellular carcinoma, liver-related mortality, and gastrointestinal bleeding in persons with chronic hepatitis B or C virus infection.
Background. The long-term effect of sustained virologic response (SVR) to antiviral therapy on the risk developing hepatocellular carcinoma (HCC), liver complications, liver-related death, and overall death in hepatitis C virus (HCV)–infected patients with cirrhosis is not fully known. Methods. These risks were evaluated during follow-up 351 HCV-related cirrhosis. One hundred ten SVR, 193 non-SVR, 48 who untreated included a multicenter cohort that was initiated 2001 prospectively followed...
ABSTRACT SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against COVID-19. We systematically mapped the functional and phenotypic landscape of cell responses in a large cohort unexposed individuals as well exposed family members with acute or convalescent Acute phase displayed highly activated cytotoxic phenotype that correlated various clinical markers disease severity, whereas were polyfunctional stem-like phenotype. Importantly, detectable...
MAIT cell activation and decline in blood are associated with COVID-19 severity, features that dynamically recover convalescence.
Abstract Despite notable scientific and medical advances, broader political, socioeconomic behavioural factors continue to undercut the response COVID-19 pandemic 1,2 . Here we convened, as part of this Delphi study, a diverse, multidisciplinary panel 386 academic, health, non-governmental organization, government other experts in from 112 countries territories recommend specific actions end persistent global threat public health. The developed set 41 consensus statements 57 recommendations...
Dendritic cells (DCs) and monocytes are crucial mediators of innate adaptive immune responses during viral infection, but misdirected by these may contribute to immunopathology. Here, we performed high-dimensional flow cytometry-analysis focusing on mononuclear phagocyte (MNP) lineages in SARS-CoV-2-infected patients with moderate severe COVID-19. We provide a deep comprehensive map the MNP landscape A redistribution monocyte subsets toward intermediate general decrease circulating DCs was...
Coinfection with hepatitis D virus (HDV) accelerates the progression of liver disease associated chronic B. Bulevirtide inhibits entry HDV into hepatocytes.In this ongoing phase 3 trial, patients D, or without compensated cirrhosis, were randomly assigned, in a 1:1:1 ratio, to receive bulevirtide subcutaneously at 2 mg per day (2-mg group) 10 (10-mg for 144 weeks no treatment 48 followed by 96 (control group). Patients will complete additional follow-up after end treatment. The primary point...
T cells are critical in mediating the early control of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) breakthrough infection. However, it remains unknown whether memory can effectively cross-recognize new SARS-CoV-2 variants with a broad array mutations, such as emergent hypermutated BA.2.86 variant. Here, we report two separate cohorts, including healthy controls and individuals chronic lymphocytic leukemia, that spike-specific CD4
Summary The number of hepatitis C virus ( HCV ) infections is projected to decline while those with advanced liver disease will increase. A modeling approach was used forecast two treatment scenarios: (i) the impact increased efficacy keeping treated patients constant and (ii) increasing rate. This analysis suggests that successful diagnosis a small proportion can contribute significantly reduction burden in countries studied. largest ‐related morbidity mortality occurs when combined higher...