Peter Bergman
A5066012504- Vitamin D Research Studies
- Antimicrobial Peptides and Activities
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Immunodeficiency and Autoimmune Disorders
- Immune Response and Inflammation
- Pediatric health and respiratory diseases
- Immune Cell Function and Interaction
- Vitamin C and Antioxidants Research
- Gut microbiota and health
- Diet and metabolism studies
- Plant and animal studies
- Cystic Fibrosis Research Advances
- Pharmacological Effects and Toxicity Studies
- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Streptococcal Infections and Treatments
- Microbial infections and disease research
- Insect and Arachnid Ecology and Behavior
- Respiratory viral infections research
- Lipoproteins and Cardiovascular Health
- Workplace Health and Well-being
- Neuropeptides and Animal Physiology
- Immunotherapy and Immune Responses
- Chronic Lymphocytic Leukemia Research
Karolinska University Hospital
2016-2025
Karolinska Institutet
2016-2025
Svenska Örtmedicinska Institute
2023
Stockholm University
2022
Rockefeller University
2022
National Bureau of Economic Research
2021
The University of Texas at Austin
2021
Columbia University
2018
National Center for Infectious Diseases
2015
Czech Academy of Sciences, Institute of Microbiology
2015
Abstract The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron (B.1.1.529) variant concern (VOC) has destabilized global efforts to control impact disease 2019 (COVID-19). Recent data have suggested that B.1.1.529 can readily infect people with naturally acquired or vaccine-induced immunity, facilitated in some cases by viral escape from antibodies neutralize ancestral SARS-CoV-2. However, appears be relatively uncommon such individuals, highlighting a...
Autosomal inborn errors of type I IFN immunity and autoantibodies against these cytokines underlie at least 10% critical COVID-19 pneumonia cases. We report very rare, biochemically deleterious X-linked TLR7 variants in 16 unrelated male individuals aged 7 to 71 years (mean: 36.7 years) from a cohort 1,202 patients 0.5 99 52.9 with unexplained pneumonia. None the 331 asymptomatically or mildly infected 1.3 102 38.7 tested carry such (p = 3.5 × 10-5). The phenotypes five hemizygous relatives...
The microbial metabolite Trimethylamine-N-oxide (TMAO) has been linked to adverse cardiovascular outcome and mortality in the general population.To assess contribution of TMAO inflammation chronic kidney disease (CKD) patients ranging from mild-moderate end-stage 1) associations with glomerular filtration rate (GFR) 2) effect dialysis renal transplantation (Rtx) 3) association inflammatory biomarkers 4) its predictive value for all-cause mortality.Levels metabolites were quantified by a...
Abstract Background We previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent interferon (IFN) immunity or autoantibodies against IFN, account for 15–20% cases life-threatening COVID-19 in unvaccinated patients. Therefore, the determinants remain be identified ~ 80% cases. Methods report here a genome-wide rare variant burden association analysis 3269 patients with COVID-19, 1373 SARS-CoV-2-infected individuals without pneumonia. Among 928...
T cells are critical in mediating the early control of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) breakthrough infection. However, it remains unknown whether memory can effectively cross-recognize new SARS-CoV-2 variants with a broad array mutations, such as emergent hypermutated BA.2.86 variant. Here, we report two separate cohorts, including healthy controls and individuals chronic lymphocytic leukemia, that spike-specific CD4
Shigella is a major cause of morbidity, mortality, and growth retardation for children in developing countries. Emergence antibiotic resistance among Shigellae demands the development effective medicines. Previous studies found that endogenous antimicrobial peptide LL-37 down-regulated rectal epithelium patients during shigellosis butyrate up-regulates expression colonic epithelial cells vitro decreases severity inflammation experimental shigellosis. In this study, Shigella-infected...
The antimicrobial peptide LL-37 is the only cathelicidin that has been described in humans. exerts chemotactic, immunomodulatory and angiogenic effects; activities are mediated through binding to formyl receptor like (FPRL)-1 receptor. Agonistic ligation of FPRL-1 can also induce down-regulation HIV-1 chemokine receptors reduce susceptibility infection vitro. Therefore, we have evaluated capacity inhibit Here demonstrate inhibits replication PBMC, including primary CD4+ T cells. This...
Low serum levels of 25-hydroxyvitamin D(3) are associated with an increased risk respiratory tract infections (RTIs). Clinical trials vitamin against various have been carried out but data so far not conclusive. Thus, there is a need for additional randomised controlled effects on infections.To investigate if supplementation could reduce infectious symptoms and antibiotic consumption among patients antibody deficiency or frequent RTIs.A double-blind trial.Karolinska University Hospital,...
LL-37 is a human antimicrobial peptide (AMP) of the cathelicidin family with multiple activities including mediator vitamin D-induced autophagy in macrophages, resulting intracellular killing Mycobacterium tuberculosis (Mtb). In previous trial healthy volunteers, we have shown that expression and subsequent Mtb-killing can be further enhanced by 4-phenylbutyrate (PBA), also an inducer expression. Here, explore potential mechanism(s) behind PBA LL-37-induced Mtb. Mtb infection macrophages...
Background Development of new tuberculosis (TB) drugs and alternative treatment strategies are urgently required to control the global spread TB. Previous results have shown that vitamin D3 (vitD3) 4-phenyl butyrate (PBA) potent inducers host defense peptide LL-37 possess anti-mycobacterial effects. Objective To examine if oral adjunctive therapy with 5,000IU vitD3 or 2x500 mg PBA PBA+vitD3 standard chemotherapy would lead enhanced recovery in sputum smear-positive pulmonary TB patients....
Background. Streptococcus pneumoniae forms part of the normal nasopharyngeal flora but can also cause a broad spectrum inflammatory diseases. Vitamin D has potent effects on human immunity, including induction antimicrobial peptides and suppression T-cell proliferation, its ability to modulate immune response pneumococci is unknown. Methods. Monocyte-derived dendritic cells (DCs) were stimulated with pneumococcal peptidoglycan (PGN) in presence or absence vitamin D. Expression maturation...
Abstract Background A 2017 meta-analysis of data from 25 randomised controlled trials vitamin D supplementation for the prevention acute respiratory infections revealed a protective effect intervention. Since then, 20 new RCTs have been completed. Methods Systematic review and (RCTs) ARI using random effects model. Pre-specified sub-group analyses were done to determine whether on risk varied according baseline 25-hydroxyvitamin (25[OH]D) concentration or dosing regimen. We searched MEDLINE,...
Many immunocompromised patients mount suboptimal humoral immunity after SARS-CoV-2 mRNA vaccination. Here, we assessed the single-cell profile of SARS-CoV-2-specific T cells post-mRNA vaccination in healthy individuals and with various forms immunodeficiencies. Impaired vaccine-induced cell-mediated was observed many patients, particularly solid-organ transplant chronic lymphocytic leukemia patients. Notably, an inherited lack mature B cells, i.e., X-linked agammaglobulinemia (XLA) displayed...
Mpox represents a persistent health concern with varying disease severity. Reinfections mpox virus (MPXV) are rare, possibly indicating effective memory responses to MPXV or related poxviruses, notably vaccinia (VACV) from smallpox vaccination. We assessed cross-reactive and virus-specific CD4
Although evidence has shown that vitamin D (VD) influences gut homeostasis, limited knowledge is available how VD regulates intestinal immunity against bacterial infection. In the present study, cyp2r1 mutant zebrafish, lacking capacity to metabolize VD, and zebrafish fed a diet devoid of were utilized as VD-deficient animal models. Our results confirmed expression antimicrobial peptides (AMPs) IL-22 was restrained susceptibility infection increased in zebrafish. Furthermore, induced AMP...