Christèle Kyheng
A5081879638- Food Allergy and Anaphylaxis Research
- Immunodeficiency and Autoimmune Disorders
- Respiratory viral infections research
- Parathyroid Disorders and Treatments
- interferon and immune responses
- Drug-Induced Adverse Reactions
- Immune Response and Inflammation
- Bariatric Surgery and Outcomes
- SARS-CoV-2 and COVID-19 Research
- Nutrition and Health in Aging
- Eosinophilic Esophagitis
- Biomedical Research and Pathophysiology
- Neurological Complications and Syndromes
- Diet and metabolism studies
- Hemoglobinopathies and Related Disorders
- Blood donation and transfusion practices
- Alkaline Phosphatase Research Studies
- Pesticide Exposure and Toxicity
- Trace Elements in Health
- Bone fractures and treatments
- Obesity and Health Practices
- Eating Disorders and Behaviors
- Hip disorders and treatments
- Cardiovascular Disease and Adiposity
- Parvovirus B19 Infection Studies
Bicêtre Hospital
2018-2024
Assistance Publique – Hôpitaux de Paris
2019-2024
Université Paris-Saclay
2021-2024
Autosomal inborn errors of type I IFN immunity and autoantibodies against these cytokines underlie at least 10% critical COVID-19 pneumonia cases. We report very rare, biochemically deleterious X-linked TLR7 variants in 16 unrelated male individuals aged 7 to 71 years (mean: 36.7 years) from a cohort 1,202 patients 0.5 99 52.9 with unexplained pneumonia. None the 331 asymptomatically or mildly infected 1.3 102 38.7 tested carry such (p = 3.5 × 10-5). The phenotypes five hemizygous relatives...
Abstract Background We previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent interferon (IFN) immunity or autoantibodies against IFN, account for 15–20% cases life-threatening COVID-19 in unvaccinated patients. Therefore, the determinants remain be identified ~ 80% cases. Methods report here a genome-wide rare variant burden association analysis 3269 patients with COVID-19, 1373 SARS-CoV-2-infected individuals without pneumonia. Among 928...
Background The objective was to determine whether high-flow nasal cannula (HFNC), a promising respiratory support in infant bronchiolitis, could reduce the proportion of treatment failure requiring escalation care. Methods In this randomised controlled trial, we assigned infants aged <6 months who had moderate bronchiolitis receive either HFNC at 3 L·kg −1 ·min or standard oxygen therapy. Crossover not allowed. primary outcome patients care (mostly noninvasive ventilation) within 7 days...
X-linked hypophosphatemia (XLH) is a rare disease characterized by low phosphate levels. Scientific evidence points to link between and obesity in general population. The aim of our longitudinal observational study was investigate the prevalence associated factors large cohort children with XLH.We studied 172 XLH-children 5-20 years age (113 girls/59 boys). Anthropometric parameters (weight, height, BMI) were collected at birth during follow-up mean ages 5.3, 8.2, 11.3, 15.9 (groups 1, 2, 3,...
We previously reported inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity in 1-5% unvaccinated patients with life-threatening COVID-19, auto-antibodies against IFN another 15-20% cases.We report here a genome-wide rare variant burden association analysis 3,269 COVID-19 (1,301 1,968 new patients), 1,373 SARS-CoV-2-infected individuals without pneumonia. A quarter the tested had antibodies (234 928) were excluded from analysis.No gene reached significance. Under...
Growing body of scientific evidence points to link between fibroblast growth factor-23 (FGF-23) and unfavourable metabolic profile (obesity, insulin resistance, hyperglycemia) all-cause mortality in general population with normal kidney function. On the other hand, there is little information about situations characterized by pathophysiologically high FGF-23 such as chronic disease X-linked hypophosphatemia (XLH). The aim present longitudinal observational study was investigate...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences on calcified tissues ISSN 2052-1219 (online)
Children with liver transplantation (LT) treated tacrolimus can develop IgE-mediated food allergies. LT children were addressed by hepatologist pediatricians to an allergist pediatrician for suspicion of allergy reactions. A standardized questionnaire, including history personal and familial atopy, was performed each child. Skin prick test (SPT), specific IgE recombinants allergens realized SPT biological tests before after child compared. Thirty who underwent at age 2,8 years (2 months-10...