A5037487121- Dialysis and Renal Disease Management
- Parathyroid Disorders and Treatments
- Nutrition and Health in Aging
- Iron Metabolism and Disorders
- Chronic Kidney Disease and Diabetes
- Blood Pressure and Hypertension Studies
- Vitamin D Research Studies
- Folate and B Vitamins Research
- Muscle and Compartmental Disorders
- Biomarkers in Disease Mechanisms
- Advanced Glycation End Products research
- Central Venous Catheters and Hemodialysis
- Pharmacological Effects and Toxicity Studies
- Bone health and osteoporosis research
- Liver Disease Diagnosis and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Diet and metabolism studies
- Erythropoietin and Anemia Treatment
- Pancreatitis Pathology and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Renal function and acid-base balance
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Body Composition Measurement Techniques
- Cardiovascular Health and Disease Prevention
- Renal and Vascular Pathologies
Baxter (Sweden)
2016-2025
Karolinska Institutet
2016-2025
Baxter (Austria)
1997-2025
Baxter (United States)
2007-2024
Karolinska University Hospital
2015-2024
Riphah International University
2024
Western University
2024
Linköping University
2021
Zero to Three
2021
University of Oslo
2002-2020
Quantal release of the principal excitatory neurotransmitter glutamate requires a mechanism for its transport into secretory vesicles. Within brain, complementary expression vesicular transporters (VGLUTs) 1 and 2 accounts by all known neurons. We now report identification VGLUT3 many cells generally considered to classical transmitter with properties very different from glutamate. Remarkably, subpopulations inhibitory neurons as well cholinergic interneurons, monoamine neurons, glia express...
ABSTRACT. Various studies suggest a strong association between nutrition and clinical outcome in hemodialysis (HD) patients. Several morbidity factors that per se increase the risk of poor outcome, such as cardiovascular disease (CVD) inflammation, may also cause malnutrition. Among laboratory parameters used to assess nutritional status, serum albumin appears be particularly predictor mortality. This study assessed importance status inflammation other comorbidity predictors mortality HD...
Vesicular glutamate transporters (VGLUTs) 1 and 2 show a mutually exclusive distribution in the adult brain that suggests specialization for synapses with different properties of release. Consistent this distribution, inactivation VGLUT1 gene silenced subset ofexcitatory neurons adult. However, same cell populations exhibited VGLUT1-independent transmission early life. Developing hippocampal transiently coexpressed VGLUT2 at distinct synaptic sites short-term plasticity. The loss also...
Reduced muscle mass and strength are prevalent conditions in dialysis patients. However, not congruent; can diminish even though is maintained or increased. This study addresses phenotype mortality associations of these dysfunction entities alone combination (i.e., concurrent loss strength/mobility, here defined as sarcopenia).This included 330 incident patients (203 men, mean age 53±13 years, GFR 7±2 ml/min per 1.73 m(2)) recruited between 1994 2010 followed prospectively for up to 5 years....
Abstract. Objective. The lifespan of dialysis patients is as short in with metastatic cancer disease, mainly due to cardiovascular disease (CVD). DNA methylation an important cellular mechanism modulating gene expression associated ageing, inflammation and atherosclerotic processes. Design. was analysed peripheral blood leucocytes from three different groups chronic kidney (CKD) populations (37 CKD stages 3 4 patients, 98 stage 5 20 prevalent haemodialysis patients). Thirty‐six healthy...
The microbial metabolite Trimethylamine-N-oxide (TMAO) has been linked to adverse cardiovascular outcome and mortality in the general population.To assess contribution of TMAO inflammation chronic kidney disease (CKD) patients ranging from mild-moderate end-stage 1) associations with glomerular filtration rate (GFR) 2) effect dialysis renal transplantation (Rtx) 3) association inflammatory biomarkers 4) its predictive value for all-cause mortality.Levels metabolites were quantified by a...
We studied 115 patients (69 men, 46 women) with chronic renal failure (CRF) aged younger than 70 years close to the start of dialysis therapy assess prevalence malnutrition and study relationship between various nutritional parameters in these patients. Nutritional status was classified by means subjective global assessment. Anthropometric measurements (AMs) were performed, hand-grip strength (HGS) measured using Harpenden dynamometer. Body composition, including lean body mass (LBM),...
Abstract Three closely related proteins transport glutamate into synaptic vesicles for release by exocytosis. Complementary patterns of expression in glutamatergic terminals have been reported VGLUT1 and VGLUT2. VGLUT3 shows many cells not considered to be glutamatergic. Here we describe the changes VGLUT that occur during development. increases gradually after birth eventually predominates over other isoforms telencephalic regions. Expressed at high levels shortly birth, VGLUT2 declines...
Men treated with hemodialysis (HD) have a very poor prognosis and an elevated risk of premature cardiovascular disease (CVD). In the general population, associations between low testosterone concentrations been suggested. We performed prospective observational study involving well characterized cohort 126 men HD to examine relationship concentration subsequent mortality during mean follow-up period 41 mo. Independent age, serum creatinine, sexual hormone binding globulin (SHBG), levels...
High Mobility Group Box-1 (HMGB1) is a cytokine implicated in the pathogenesis of rheumatoid arthritis (RA) and other inflammatory diseases. The cholinergic anti-inflammatory pathway, vagus nerve-dependent mechanism, inhibits HMGB1 release experimental disease models. Here, we examine relationship between nerve activity patients with RA. We compared RR interval variability, an index cardiac vagal modulation, hsCRP serum levels, scores thirteen RA eleven age- sex-matched controls. In...
Summary Background and objectives Serum albumin is a widely used biomarker of nutritional status in patients with CKD; however, its usefulness debated. This study investigated serum correlation several markers incident prevalent dialysis patients. Design, setting, participants, & measurements In cross-sectional study, (bromocresol purple), other biochemical (serum creatinine), clinical (subjective global assessment [SGA]), anthropometric (handgrip strength; skinfold thicknesses),...
Abstract. Carrero JJ, Qureshi AR, Axelsson J, Yilmaz MI, Rehnmark S, Witt MR, Bárány P, Heimbürger O, Suliman ME, Alvestrand A, Lindholm B, Stenvinkel P (Karolinska Institutet, Stockholm; and Karo Bio AB, Novum, Huddinge; Sweden). Clinical biochemical implications of low thyroid hormone levels (total free forms) in euthyroid patients with chronic kidney disease. J Intern Med 2007; 262 : 690–701. Objectives. In this study, we explore the associations decreased inflammation, wasting survival...