A5036051354- Food Allergy and Anaphylaxis Research
- Asthma and respiratory diseases
- Immunodeficiency and Autoimmune Disorders
- Dermatology and Skin Diseases
- Vitamin D Research Studies
- Allergic Rhinitis and Sensitization
- Respiratory viral infections research
- Kawasaki Disease and Coronary Complications
- Urticaria and Related Conditions
- Immune Cell Function and Interaction
- Vitamin C and Antioxidants Research
- Eosinophilic Esophagitis
- Autoimmune and Inflammatory Disorders Research
- Climate Change and Health Impacts
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Neonatal Respiratory Health Research
- Inflammasome and immune disorders
- Vasculitis and related conditions
- Diabetes and associated disorders
- Drug-Induced Adverse Reactions
- Blood disorders and treatments
- Folate and B Vitamins Research
- Adolescent and Pediatric Healthcare
- Congenital Heart Disease Studies
Pontificia Universidad Católica de Chile
2016-2025
Institute for Health Metrics and Evaluation
2024
University of Washington
2024
Millennium Institute on Immunology and Immunotherapy
2014-2023
Nationwide Children's Hospital
2023
Harvard University
2008-2022
Boston Children's Hospital
2008-2022
Universidad del Desarrollo del Estado de Puebla
2022
Dana-Farber/Boston Children's Cancer and Blood Disorders Center
2015
Center for Rheumatology
2014
Little information is available concerning the natural history and optimal treatment of chronic nonbacterial osteomyelitis (CNO). We conducted a retrospective review to assess clinical characteristics responses large cohort pediatric CNO patients.Children diagnosed with at 3 tertiary care centers in United States between 1985 2009 were identified. Their charts reviewed, clinical, laboratory, histopathologic, radiologic data extracted.Seventy children (67% female patients) Median age onset...
Lrrc8a is a ubiquitously expressed gene that encodes leucine-rich repeat (LRR)–containing protein detected at higher levels on the surface of thymocytes than other immune cells. We generated Lrrc8a−/− mice to investigate role LRRC8A in lymphocyte development and function. had increased prenatal postnatal mortality, growth retardation, multiple tissue abnormalities. displayed modest block B cell but intact intrinsic In contrast, both Lrrc8a−/−→Rag2−/− bone marrow chimeras exhibited severe...
Abstract Background A 2017 meta-analysis of data from 25 randomised controlled trials vitamin D supplementation for the prevention acute respiratory infections revealed a protective effect intervention. Since then, 20 new RCTs have been completed. Methods Systematic review and (RCTs) ARI using random effects model. Pre-specified sub-group analyses were done to determine whether on risk varied according baseline 25-hydroxyvitamin (25[OH]D) concentration or dosing regimen. We searched MEDLINE,...
Vitamin D (VD) deficiency is common among patients with atopic dermatitis (AD) and often associated severity. However, randomized trials of VD supplementation in AD have had equivocal results, there little information regarding the effect on type 2 immunity patients.
BackgroundRespiratory syncytial virus (RSV) is responsible for most respiratory tract infections and hospitalizations in infants represents a significant economic burden public health. The development of safe, effective, affordable vaccine priority the WHO.MethodsWe conducted double-blinded, escalating-dose phase 1 clinical trial healthy males aged 18-50 years to evaluate safety, tolerability, immunogenicity recombinant Mycobacterium bovis BCG expressing nucleoprotein RSV (rBCG-N-hRSV). Once...
Abstract Background Recent studies suggest an association between higher latitude, a proxy of vitamin D ( VD ) status, and allergic diseases. Chile provides ideal setting to study this due its latitude span high rates deficiency in southern regions. The aim is explore the associations solar radiation with anaphylaxis admission rates. Methods We reviewed admissions C hile's hospital discharge database 2001 2010 investigated radiation. Results 2316 were registered. Median age patients was 41...
To assess efficacy, pharmacokinetics (PK) and safety of intravenous (i.v.) golimumab in patients with polyarticular-course JIA (pc-JIA).Children aged 2 to <18 years active pc-JIA despite MTX therapy for ≥2 months received 80 mg/m2 at weeks 0, 4, then every 8 through week 52 plus weekly 28. The primary major secondary endpoints were PK exposure model-predicted steady-state area under the curve (AUCss) over an 8-week dosing interval 28 52, respectively. ACR response also assessed.In total, 127...
ABSTRACT Itch and pain are both mediated by small sensory fibres. Atopic dermatitis (AD) patients usually report stress‐induced flares, but the impact of stress on fibres in lesional non‐lesional skin remains inconclusive. This observational study assessed effect acute profiles subjects with AD ( n = 18) healthy controls (HC, 21). Participants completed clinical psychological questionnaires, quantitative testing was performed HC. Assessments were done before after Montreal Imaging Stress...
Hereditary folate malabsorption is characterized by deficiency with impaired transport into the central nervous system (CNS). This disease megaloblastic anemia of early appearance, combined immunodeficiency, seizures, and cognitive impairment. The immunologic are responsive but neurological signs refractory to folic-acid treatment. We report a 7-year-old girl who has congenital SLC46A1 gene mutation unable from her gut circulatory consequently blood cerebrospinal fluid (CSF). As result she...
We aimed to assess whether the presence of radiographically confirmed calcinosis hands in patients with systemic sclerosis (SSc) is associated increased osteoclastogenesis. recruited 20 SSc (10 and 10 without calcinosis) age- gender-matched healthy controls. Hand radiographs were scored using validated Scleroderma Clinical Trials Consortium (SCTC) radiographic severity score for calcinosis. To evaluate osteoclastogenesis, peripheral blood mononuclear cells (PBMCs) cultured RANKL macrophage...
Atopic dermatitis (AD) is a systemic, multifactorial disease that causes significant morbidity and health care burden in Latin America (LA). Data on AD are scarce LA. Lack of registries non-standardized study methodologies, coupled with region-specific genetic, immunological, environmental factors, hamper data collection. A panel LA experts was given series relevant questions to address before conference. Each narrative discussed edited through numerous rounds deliberation until achieving...
Mevalonate kinase deficiency (MKD) is a rare inborn error of metabolism caused by mutations in the mevalonate (MVK) gene. The clinical phenotype variable, ranging from hyperimmunoglobulinemia D and periodic fever syndrome (HIDS) to mevalonic aciduria (MA), severe metabolic disease. We report here for first time (to our knowledge) case patient with MKD congenital dyserythropoietic anemia. Clinical laboratory characteristics inflammatory attacks were compatible HIDS, but mild dysmorphic...