A5016520780- Respiratory viral infections research
- Immune Cell Function and Interaction
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- COVID-19 Clinical Research Studies
- Pneumonia and Respiratory Infections
- Kawasaki Disease and Coronary Complications
- Viral gastroenteritis research and epidemiology
- Neonatal Respiratory Health Research
- Immunodeficiency and Autoimmune Disorders
- Vaccine Coverage and Hesitancy
- SARS-CoV-2 and COVID-19 Research
- Congenital Diaphragmatic Hernia Studies
- Animal Virus Infections Studies
- Infectious Diseases and Tuberculosis
- Animal Disease Management and Epidemiology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Phenothiazines and Benzothiazines Synthesis and Activities
- Sepsis Diagnosis and Treatment
- Antibiotic Resistance in Bacteria
- Calcium signaling and nucleotide metabolism
- Blood disorders and treatments
- Macrophage Migration Inhibitory Factor
- Vasculitis and related conditions
- Microbial Metabolic Engineering and Bioproduction
Clínica Alemana
2021-2023
Universidad del Desarrollo
2021-2023
Millennium Institute on Immunology and Immunotherapy
2015-2020
Pontificia Universidad Católica de Chile
2015-2020
Universitat de Barcelona
2011-2013
Hospital Clínic de Barcelona
2011-2013
The antibody profile against autoantigens previously associated with autoimmune diseases and other human proteins in patients COVID-19 or multisystem inflammatory syndrome children (MIS-C) remains poorly defined. Here we show that 30% of adults had autoantibodies the lung antigen KCNRG, 34% antibodies to SLE-associated Smith-D3 protein. Children rarely autoantibodies; one 59 GAD65 acute onset insulin-dependent diabetes. While SLE/Sjögren’s (Ro52, Ro60, La) and/or gastritis (gastric ATPase)...
One of the major problems in production lipids for biotechnological purposes using microalgae is maintaining a high productivity these molecules without reducing cellular biomass. High rates are usually obtained by cultivating under different stress conditions. However, many changes result lower biomass productivity. Therefore, optimization culture conditions and genetic modification techniques organisms needed to generate robust new strains profitable economic use.In this work, we describe...
BackgroundRespiratory syncytial virus (RSV) is responsible for most respiratory tract infections and hospitalizations in infants represents a significant economic burden public health. The development of safe, effective, affordable vaccine priority the WHO.MethodsWe conducted double-blinded, escalating-dose phase 1 clinical trial healthy males aged 18-50 years to evaluate safety, tolerability, immunogenicity recombinant Mycobacterium bovis BCG expressing nucleoprotein RSV (rBCG-N-hRSV). Once...
Dysregulation in neutrophil extracellular trap (NET) formation and degradation may play a role the pathogenesis severity of COVID-19; however, its pediatric manifestations this disease, including multisystem inflammatory syndrome children (MIS-C) chilblain-like lesions (CLLs), otherwise known as "COVID toes," remains unclear. Studying multinational cohorts, we found that, CLLs, NETs were significantly increased serum skin. There was geographic variability prevalence MIS-C, association with...
The Human Respiratory Syncytial Virus (hRSV) and the Metapneumovirus (hMPV) are two pneunoviruses that leading agents causing acute lower respiratory tract infections (ALRTIs) affecting young infants, elderly immunocompromised patients worldwide. Since these pathogens were first discovered, many approaches for licensing of safe effective vaccines have been explored being unsuccessful to date. We previously described immunization with recombinant strains Mycobacterium bovis Bacillus...
Human NK cell deficiency (NKD) is a primary immunodeficiency in which the main clinically relevant immunological defect involves missing or dysfunctional cells. Here, we describe familial NKD case 2 siblings had substantive and neutropenia absence of other immune system abnormalities. Exome sequencing identified compound heterozygous variants Go-Ichi-Ni-San (GINS) complex subunit 4 (GINS4, also known as SLD5), an essential component human replicative helicase, demonstrate to have damaging...
Chronic kidney disease (CKD) patients have an increased risk of morbidity and mortality following SARS-CoV-2 infection. Vaccination in these is prioritized, monitoring the immune response paramount to define further vaccination strategies. This prospective study included a cohort 100 adult CKD patients: 48 with transplant (KT) 52 on hemodialysis without prior COVID-19. The were assessed for humoral cellular responses after four months anti-SARS-CoV-2 primary two-dose scheme (CoronaVac or...
Human respiratory syncytial virus (hRSV) and human metapneumovirus (hMPV) cause acute tract infections in children worldwide. Natural killer T (NKT) cells are unconventional lymphocytes, their TCRs recognize glycolipids bound to the MHC-I-like molecule, CD1d. These modulate inflammatory response viral infections. Here, we evaluated contribution of NKT both hRSV hMPV A significant decrease number neutrophils, eosinophils, CD103+DCs infiltrating lungs, as well an increased production IFN-γ,...
T cells play an essential role in the immune response against human respiratory syncytial virus (hRSV). It has been described that both CD4+ and CD8+ can contribute to clearance of during infection. However, for some individuals, such lead exacerbated detrimental inflammatory with high recruitment neutrophils lungs. The receptor most is a heterodimer consisting α β chains (αβTCR) upon antigen engagement induces activation these cells. αβTCR molecule displays broad sequence diversity defines...
Abstract Dysregulation in neutrophil extracellular trap (NET) formation and degradation may play a role the pathogenesis severity of COVID-19; however, its pediatric manifestations this disease including MIS-C chilblain-like lesions (CLL), otherwise known as “COVID toes”, remains unclear. Studying multinational cohorts, we found that, CLL, NETs were significantly increased serum skin. There was geographic variability prevalence MIS-C, association with severity. CLL samples displayed...