A5074100972- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- SARS-CoV-2 and COVID-19 Research
- T-cell and B-cell Immunology
- COVID-19 Clinical Research Studies
- Reproductive Physiology in Livestock
- Metal-Catalyzed Oxygenation Mechanisms
- Effects of Environmental Stressors on Livestock
- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- CRISPR and Genetic Engineering
- Dermatological and COVID-19 studies
- Malaria Research and Control
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Reproductive System and Pregnancy
- Neonatal and fetal brain pathology
- Genetic and phenotypic traits in livestock
- Cancer Research and Treatments
- Immunodeficiency and Autoimmune Disorders
- CAR-T cell therapy research
- Molecular Biology Techniques and Applications
- vaccines and immunoinformatics approaches
- Cytomegalovirus and herpesvirus research
- Cancer Immunotherapy and Biomarkers
- Biochemical and Molecular Research
Boundless Bio (United States)
2023-2025
Malaghan Institute of Medical Research
2020-2023
Karolinska Institutet
2020-2022
Karolinska University Hospital
2020-2022
AgResearch
2016-2018
Tissue-resident memory CD8 + T cells in unexposed oropharyngeal lymphoid tissue exhibit specificity for SARS-CoV-2.
Many immunocompromised patients mount suboptimal humoral immunity after SARS-CoV-2 mRNA vaccination. Here, we assessed the single-cell profile of SARS-CoV-2-specific T cells post-mRNA vaccination in healthy individuals and with various forms immunodeficiencies. Impaired vaccine-induced cell-mediated was observed many patients, particularly solid-organ transplant chronic lymphocytic leukemia patients. Notably, an inherited lack mature B cells, i.e., X-linked agammaglobulinemia (XLA) displayed...
Protective immune responses against respiratory pathogens, such as severe acute syndrome coronavirus 2 (SARS-CoV-2) and influenza virus, are initiated by the mucosal system. However, most licensed vaccines administered parenterally largely ineffective at inducing immunity. The development of safe effective has been hampered lack a suitable adjuvant. In this study we explore class adjuvant that harnesses mucosal-associated invariant T (MAIT) cells. We show evidence intranasal immunization...
Glycolipid-peptide conjugate vaccines protect against rodent malaria by generating large numbers of liver CD8 + T RM cells.
Adaptive immune responses have been studied extensively in the course of mRNA vaccination against COVID-19. Considerably fewer studies assessed effects on innate cells. Here, we characterized NK cells healthy individuals and immunocompromised patients an anti-SARS-CoV-2 BNT162b2 prospective, open-label clinical vaccine trial. See trial registration description notes. Results revealed preserved cell numbers, frequencies, subsets, phenotypes, function as through consecutive peripheral blood...
Abstract Mucosa-associated invariant T (MAIT) cells are unconventional with innate-like capacity to rapidly respond microbial infection via MR1-restricted antigen recognition. Emerging evidence indicate that they can also act as rapid sensors of viral innate cytokine activation. However, their possible role in the immune response mRNA vaccination is unknown. Here, we evaluated involvement MAIT individuals vaccinated BNT162b2 SARS-CoV-2 vaccine. cell levels, phenotype and function circulation...
Mucosal-associated invariant T (MAIT) cells are antibacterial effector that react to pyrimidines derived from bacterial riboflavin synthesis presented by the monomorphic molecule MR1. A major challenge in MAIT cell research is commonly used agonist precursor, 5-amino-6-d-ribitylaminouracil (5-A-RU), labile autoxidation, resulting a loss of biological activity. Here, we characterize two independent autoxidation processes LCMS. To overcome marked instability, report 5-A-RU prodrug generated...
T-cell immune responses following vaccination with mRNA BNT162b2 against SARS-CoV-2 in patients chronic lymphocytic leukemia: results from a prospective open-label clinical trial *Ab baseline = 0.4 U/mL; seropositive >0.8 U/mL. n 48 (with d35 data).Ab: antibodies; ELISpot: enzyme-linked
Abstract KRAS targeted inhibitors have shown promising clinical data in multiple recalcitrant cancers with activating mutations. The mutant-specific, pan, and multi-RAS targeting landscape is rapidly evolving; however, both intrinsic acquired resistance to these therapies remain a significant challenge. Mechanisms of include high copy number amplification and/or MAPK-pathway genes, activation alternative oncogenic pathways, secondary mutations RAS-family members. In driven cancers, estimated...
Drug Prescribing for Patients with Chronic Kidney Disease in General Practice: a Cross-Sectional Study
Abstract Patients whose tumors harbor oncogene amplification on extrachromosomal DNA (ecDNA) fail to respond targeted or immune therapy and have poor prognosis. ecDNA are cancer-specific circular fragments of genomic engendered with unique properties, including open chromatin architecture associated hyper transcription a predilection for structural variation. In addition, ecDNA+ tremendous copy number heterogeneity mediated through acentric, non-Mendelian segregation. These properties afford...
Abstract Focal, high copy number amplifications of prevalent oncogenes (e.g., MYC, EGFR) frequently occur on extrachromosomal DNA (ecDNA), highly transcribed units circular, non-chromosomal DNA. While use targeted therapies is associated with improved survival in patients cancers that have activating oncogene mutations or fusions, they demonstrated limited activity for whose tumors harbor amplifications, including those mediated by ecDNA. We previously identified Checkpoint Kinase 1 (CHK1)...
During the peripartum period, dairy cows often have signs of inflammation. Various stresses, including infectious and metabolic diseases, been discussed as causative for this In study, expression profiles 17 immune markers were measured in whole blood preparations from 78 over a time frame starting 1 wk before calving to 4 after calving. Additionally, effects far-off close-up feeding on function during period investigated. Cows assigned 2 levels late lactation achieve low high BCS at dry-off...
Abstract Protective immune responses against respiratory pathogens, including influenza virus are initiated by the mucosal system. However, most licensed vaccines administered parenterally and largely ineffective at inducing immunity. The development of safe effective has been hampered lack a suitable adjuvant. In this study we explore novel class adjuvant that harness mucosal-associated invariant T (MAIT) cells. We show evidence intranasal immunisation MAIT cell agonists co-administered...
Abstract Introduction: KRASG12C inhibitors are a new therapeutic approach to treat KRAS mutant-driven cancers, but as with other oncogene directed therapies, adaptive resistance develops quickly and frequently. The predominant mechanisms 1) secondary mutations in and/or mitogen-activated protein kinase (MAPK) signaling genes 2) amplification of or MAPK genes. Extrachromosomal DNA (ecDNA) the site focal high copy number gene amplifications human cancers. Previous studies have demonstrated on...