A5091850307- Immune Cell Function and Interaction
- Malaria Research and Control
- Congenital gastrointestinal and neural anomalies
- Pediatric Urology and Nephrology Studies
- CAR-T cell therapy research
- Urological Disorders and Treatments
- Intestinal Malrotation and Obstruction Disorders
- Mosquito-borne diseases and control
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Adenosine and Purinergic Signaling
- Complement system in diseases
- Diverticular Disease and Complications
- Esophageal and GI Pathology
- Ureteral procedures and complications
- HIV Research and Treatment
- Gastrointestinal disorders and treatments
- CRISPR and Genetic Engineering
- Cancer Immunotherapy and Biomarkers
- Chronic Lymphocytic Leukemia Research
- Phytochemicals and Medicinal Plants
- Down syndrome and intellectual disability research
- Intraperitoneal and Appendiceal Malignancies
- Coronary Artery Anomalies
- Occupational Health and Burnout
The University of Melbourne
2020-2025
Peter MacCallum Cancer Centre
2023-2025
Peter Doherty Institute
2020-2025
Universidade do Vale do Rio dos Sinos
2024
Harvard University
2023
Neste Oil (Finland)
2019
Universidade de São Paulo
2014-2019
Hospital Curry Cabral
2019
Hospital de Santa Maria
2017
Fundação Oswaldo Cruz
2011-2014
Abstract Chimeric antigen receptor (CAR) T cell therapy has transformed the treatment of haematological malignancies such as acute lymphoblastic leukaemia, B lymphoma and multiple myeloma 1–4 , but efficacy CAR in solid tumours been limited 5 . This is owing to a number factors, including immunosuppressive tumour microenvironment that gives rise poorly persisting metabolically dysfunctional cells. Analysis anti-CD19 cells used clinically shown positive outcomes are associated with more...
The antimalarial activities of physalins B, D, F, and G (1–4), isolated from Physalis angulata, were investigated. In silico analysis using the similarity ensemble approach (SEA) database predicted activity each these compounds, which shown an in vitro assay against Plasmodium falciparum. However, treatment P. berghei-infected mice with 3 increased parasitemia levels mortality, whereas 2 was protective, causing a reduction delay mortality mice. exacerbation vivo infection by is probably due...
A complete understanding of the mechanisms underlying acquisition protective immunity is crucial to improve vaccine strategies eradicate malaria. However, it still unclear whether recognition damage signals influences immune response Plasmodium infection. Adenosine triphosphate (ATP) accumulates in infected erythrocytes and released into extracellular milieu through ion channels erythrocyte membrane or upon rupture. The P2X7 receptor senses ATP induces CD4 T cell activation death. Here we...
Glycolipid-peptide conjugate vaccines protect against rodent malaria by generating large numbers of liver CD8 + T RM cells.
Dendritic cells (DCs) are phagocytes that highly specialized for antigen presentation. Heterogeneous populations of macrophages and DCs form a phagocyte network inside the red pulp (RP) spleen, which is major site control blood-borne infections such as malaria. However, dynamics splenic during Plasmodium poorly understood, limiting our knowledge regarding their protective role in Here, we used vivo experimental approaches enabled us to deplete or visualize order clarify these issues. To...
INTRODUÇÃO: A coarctação da aorta é uma condição congênita caracterizada pelo estreitamento luz arterial, associada ao desenvolvimento de aneurismas cerebrais devido à hipertensão arterial persistente. Essa promove enfraquecimento das paredes vasculares, aumentando o risco hemorragias intracranianas e desfechos neurológicos adversos. OBJETIVOS: Investigar a relação entre não tratada cerebrais, abordando mecanismos fisiopatológicos, estratégias diagnósticas terapêuticas, além relevância do...
O carcinoma de células renais (CCR) é frequentemente diagnosticado incidentalmente devido ao aumento da utilização exames imagem, como a ultrassonografia e tomografia computadorizada. A detecção precoce massas renais, muitas vezes assintomáticas, essencial para um manejo eficaz. Sintomas dor no flanco, hematúria perda peso podem ocorrer, mas são pouco comuns, o que leva diagnóstico em estágios mais avançados muitos pacientes. As modalidades especialmente ressonância magnética, desempenham...
A cirurgia bariátrica tem se consolidado como uma das estratégias mais eficazes no tratamento da obesidade severa, sobretudo quando abordagens conservadoras mostram insuficientes. Diversas técnicas cirúrgicas são atualmente empregadas, com destaque para o bypass gástrico em Y de Roux, a gastrectomia vertical (sleeve gástrico) e, menor escala, banda gástrica ajustável. Cada técnica atua por mecanismos distintos, restrição ingestão alimentar, má absorção nutrientes e modulação hormonal,...
<title>Abstract</title> The efficacy of chimeric antig en receptor (CAR) T cell therapy in solid tumors is limited by immunosuppression and antigen heterogeneity. To overcome these barriers, “armored” CAR cells, which secrete proinflammatory cytokines, have been developed. However, their clinical application has due to toxicities related peripheral expression the armoring transgene. Here, we developed a novel CRISPR knock-in strategy that uses endogenous gene regulatory mechanisms drive...
Renal parenchymal injury in vesicoureteral reflux occurs early, most patients before age 3 years. It is generally believed that early prevention of urinary tract infections may decrease the amount renal damage. Endoscopic treatment for has become an established alternative to long-term antibiotic prophylaxis and ureteral reimplantation. We prospectively evaluated effectiveness safety dextranomer/hyaluronic acid copolymer high grade infants.A total 276 infants, including 124 boys 152 girls,...
The familial nature of vesicoureteral reflux is well recognized. Screening siblings for controversial. We identified a group index patients with who are most likely to be affected. also risk factors renal scarring.Between 1998 and 2007 the parents 215 grades III V were asked permission screen younger than 6 years reflux. 251 divided into those diagnosed following urinary tract infection screened. Siblings 3 old at diagnosis. Dimercapto-succinic acid scans available in 172 180 siblings.Of 105...
Abstract Malaria causes hepatic inflammation and damage, which contribute to disease severity. The pro-inflammatory cytokine interleukin (IL)-1α is released by non-hematopoietic or hematopoietic cells during liver injury. This study established the role of IL-1α in pathology caused blood-stage P. chabaudi malaria. During acute infection, necrosis were accompanied NLRP3 inflammasome-independent production. Systemically, deficiency attenuated weight loss hypothermia but had minor effects on...
This study reports on the design, synthesis and antiparasitic activity of three new semi-synthetic naphthoquinones structurally related to naturally-occurring lapachol lapachone. Of compounds tested, 3-(3-methylbut-1-en-1-yl)-1,4-dioxo-1,4-dihydronaphthalen-2-yl acetate (1) was most active against Plasmodium falciparum among both natural naphthoquinones, showing potent selective activity. Compound 1 able reduce in vitro parasite burden, cell cycle, as well blood parasitemia berghei-infected...
Thorough understanding of the role CD4 T cells in immunity can be greatly assisted by study responses to defined specificities. This requires knowledge Plasmodium-derived immunogenic epitopes, which only a few have been identified, especially for mouse C57BL/6 background. We recently developed TCR transgenic line, termed PbT-II, that produces CD4+ specific an MHC class II (I-Ab)-restricted Plasmodium epitope and is responsive both sporozoites blood-stage P. berghei. Here, we identify peptide...