A5067487234- Malaria Research and Control
- vaccines and immunoinformatics approaches
- Invertebrate Immune Response Mechanisms
- Distributed and Parallel Computing Systems
- Mosquito-borne diseases and control
- Evolution and Genetic Dynamics
- Genomics and Phylogenetic Studies
- Parasitic Infections and Diagnostics
- Computational Drug Discovery Methods
- Parasite Biology and Host Interactions
- Genetics, Bioinformatics, and Biomedical Research
- Parasites and Host Interactions
- Genetic diversity and population structure
- Environmental DNA in Biodiversity Studies
- Clostridium difficile and Clostridium perfringens research
- Trypanosoma species research and implications
- Coccidia and coccidiosis research
- Antibiotic Resistance in Bacteria
- Gut microbiota and health
- Aquaculture disease management and microbiota
- Genetics, Aging, and Longevity in Model Organisms
- Insect symbiosis and bacterial influences
- Heat shock proteins research
The University of Melbourne
2020-2024
Baker Heart and Diabetes Institute
2024
Walter and Eliza Hall Institute of Medical Research
2020-2024
University of Washington
2023
Seattle University
2023
Deakin University
2020-2023
Burnet Institute
2020-2023
Swansea University
2020
University of Montana
2016
Investigation of the diversity malaria parasite antigens can help prioritize and validate them as vaccine candidates identify most common variants for inclusion in formulations. Studies virulent human parasite, Plasmodium falciparum, have focused on a handful well-known antigens, while several others never been studied. Here we examine global population structure leading candidate P. falciparum using MalariaGEN Pf3K (version 5.1) resource, comprising more than 2600 genomes from 15 endemic...
Monitoring antibiotic-resistant bacteria (ARB) and understanding the effects of antimicrobial drugs on human microbiome resistome are crucial for public health. However, no study has investigated association between treatment microbiome–resistome relationship in long-term care facilities, where residents act as reservoirs ARB but not included national surveillance ARB. We conducted shotgun metagenome sequencing oral stool samples from facility explored using two types comparisons:...
The nematode Caenorhabditis elegans is well established as a system for characterization and discovery of molecular mechanisms mediating microbe-specific inducible innate immune responses to human pathogens. Coxiella burnetii an obligate intracellular bacterium that causes flu-like syndrome in humans (Q fever), abortions domesticated livestock, worldwide. Initially, when wild type C. (N2 strain) was exposed mCherry-expressing (CCB) number overt pathological manifestations resulted, including...
Abstract Large-scale comparative genomics- and population genetic studies generate enormous amounts of polymorphism data in the form DNA variants. Ultimately, goal many these is to associate variants phenotypes or fitness. We introduce VIVID, an interactive, user-friendly web application that integrates a wide range approaches for encoding genotypic phenotypic information any organism disease, from individual population, three-dimensional (3D) space. It allows mutation mapping annotation,...
Individuals acquire immunity to clinical malaria after repeated Plasmodium falciparum infections. Immunity disease is thought reflect the acquisition of a repertoire responses multiple alleles in diverse parasite antigens. In previous studies, we identified polymorphic sites within individual antigens that are associated with immune evasion by examining antigen allele dynamics individuals followed longitudinally. Here expand this approach analyzing genome-wide polymorphisms using whole...
Plasmodium parasites, the eukaryotic pathogens that cause malaria, feature three distinct invasive forms tailored to host environment they must navigate and invade for life cycle progression. One conserved of these is micronemes, apically oriented secretory organelles involved in egress, motility, adhesion, invasion. Here we investigate role GPI-anchored micronemal antigen (GAMA), which shows a localization all zoite rodent-infecting species berghei. ∆GAMA parasites are severely defective...
<title>Abstract</title> Sexual recombination is a hallmark of eukaryotic evolution. Without recombination, asexual eukaryotes should succumb to deleterious mutations and more rapidly evolving pathogens. Giardia duodenalis, parasitic protist, sits within one the earliest-branching lineages has no known sexual stage. Whether are ‘ancient asexuals’ long explored but unresolved. Here, we find clear evidence sex in also discover an sublineage that broader host range than its ancestor. This...
Abstract Investigation of the diversity malaria parasite antigens can help prioritize and validate them as vaccine candidates identify most common variants for inclusion in formulations. Studies on Plasmodium falciparum antigen have focused well-known while several others has never been studied. Here we provide an overview population structure leading candidate P. using MalariaGEN Pf3K (version 5.1) resource, comprising more than 2600 genomes from 15 endemic countries. We developed a...
Abstract Individuals acquire immunity to clinical malaria after repeated Plasmodium falciparum infections. This disease is thought reflect the acquisition of a repertoire responses multiple alleles in diverse parasite antigens. In previous studies, we identified polymorphic sites within individual antigens that are associated with immune evasion by examining antigen allele dynamics individuals followed longitudinally. Here expand this approach analyzing genome-wide polymorphisms using whole...
Abstract Large-scale comparative genomics- and population genetic studies generate enormous amounts of polymorphism data in the form DNA variants. Ultimately, goal many these is to associate variants phenotypes or fitness. We introduce VIVID, an interactive, user-friendly web application that integrates a wide range approaches for encoding genotypic phenotypic information any organism disease, from individual population, three-dimensional (3D) space. It allows mutation mapping annotation,...
Plasmodium falciparum Reticulocyte Binding Protein Homologue (RH5), a leading malaria vaccine candidate, is essential for erythrocyte invasion by the parasite, interacting with human host receptor, basigin. RH5 has small number of polymorphisms relative to other blood-stage antigens, and in vitro studies have shown that vaccine-induced antibodies raised against are strain-transcending, however most investigating diversity been done Africa. Understanding genetic evolution antigens regions...
ABSTRACT The complex life cycle of Plasmodium parasites, the eukaryotic pathogens that cause malaria, features three distinct invasive forms tailored specifically to equally host environment they must navigate and invade for progression cycle. One conserved feature all these is presence micronemes, apically oriented secretory organelles involved in egress, motility, adhesion invasion. Micronemes are their specific stage contents. Here we investigate role GPI-anchored micronemal antigen...