Roundup and its active ingredient glyphosate are among the most widely used herbicides worldwide may contaminate surface waters. Research suggests both induce oxidative stress in fish also cause reproductive toxicity mammalian systems. We aimed to investigate effects of potential associated mechanisms toxicity. To do this, we conducted a 21-day exposure breeding zebrafish (Danio rerio) 0.01, 0.5, 10 mg/L (glyphosate acid equivalent) glyphosate. reduced egg production but not fertilization...

Bisphenol A (BPA) is a commercially important high production chemical widely used in epoxy resins and polycarbonate plastics, ubiquitous the environment. Previous studies demonstrated that BPA activates estrogenic signaling pathways associated with adverse effects on reproduction vertebrates exposure can induce epigenetic changes. We aimed to investigate reproductive of fish model document its mechanisms toxicity. exposed breeding groups zebrafish (Danio rerio) 0.01, 0.1, 1 mg/L for 15 d....

The microbiome has a crucial influence on host phenotype and is of broad interest to ecological evolutionary research. Yet, the extent variation that occurs in within between populations unclear. We characterized skin gut microbiomes seven juvenile Atlantic salmon (Salmo salar) inhabiting diverse range environments, including hatchery-reared wild populations. found shared operational taxonomic units (OTUs) across all core microbiota for fish, but diversity structure both microbial...

Glyphosate, the active ingredient in Roundup formulations, is most widely used herbicide worldwide, and as a result contaminates surface waters has been detected food residues, drinking water human urine, raising concerns for potential environmental health impacts. Research shown that glyphosate can induce broad range of biological effects exposed organisms, particularly via generation oxidative stress. However, there no comprehensive investigation global molecular mechanisms toxicity any...

Microbial communities associated with the gut and skin are strongly influenced by environmental factors, can rapidly adapt to change. Historical processes may also affect microbiome. In particular, variation in microbial colonisation early life has potential induce lasting effects on assemblages. However, little is known about relative extent of microbiome plasticity or importance historical following change, especially for nonmammalian species. To investigate this we performed a reciprocal...

Stress experienced during early life may have lasting effects on the immune system, with impacts health and disease dependent nature duration of stressor. The epigenome is especially sensitive to environmental stimuli represents a potential mechanism through which stress cause long-lasting effects. However, extent responds differently chronic vs acute stressors unclear, for non-mammalian species. We examined (cold-shock embryogenesis) (absence tank enrichment larval-stage) global gene...

Exposure to environmental stressors can compromise fish health and fitness. Little is known about how stress-induced microbiome disruption may contribute these adverse effects, including cortisol influences microbial communities. We exposed juvenile Atlantic salmon a mild confinement stressor for two weeks. then measured in the plasma, skin-mucus faeces, characterised skin faecal microbiome. Faecal concentrations increased stress, were positively correlated with plasma cortisol. Elevated was...

Worldwide, a number of viable populations fish are found in environments heavily contaminated with metals, including brown trout (Salmo trutta) inhabiting the River Hayle South-West England. This population is chronically exposed to water-borne mixture copper and zinc, at concentrations lethal naïve fish. We aimed investigate molecular mechanisms employed by tolerate high metal concentrations. To achieve this, we combined tissue analysis whole-transcriptome profiling using RNA-seq on an...

Captive animal populations, be it for food production or conservation programmes, are often maintained at densities far beyond those in natural environments, which can have profound effects on behaviour, immune and stress levels, ultimately welfare. How such alterations impact transcriptional responses to pathogen infection is a 'different kettle of fish' remains poorly understood. Here, we assessed survival gene expression profiles infected fish reared two different elucidate potential...

Farmed fish are commonly exposed to stress in intensive aquaculture systems, often leading immune impairment and increased susceptibility disease. As microbial communities associated with the gut skin vital host health disease resilience, disruption of microbiome integrity could contribute adverse consequences exposure. Little is known about how affects microbiome, especially during sensitive early life stages when initial colonisation proliferation host-associated take place. Therefore, we...

Hypoxia is a global and increasingly important stressor in aquatic ecosystems, with major impacts on biodiversity worldwide. Hypoxic waters are often contaminated wide range of chemicals but little known about the interactions between these stressors. We investigated effects hypoxia responses zebrafish (Danio rerio) embryos to copper, widespread contaminant. showed that during continuous exposures copper toxicity was reduced by over 2-fold under compared normoxia. When were conducted 24 h...

Abstract Early life stages of aquatic organisms are particularly vulnerable to climatic stressors; however, they difficult monitor due challenges in sampling and morphological identification. Environmental DNA (eDNA) from water samples represents an opportunity for rapid, nondestructive monitoring community composition as well single species monitoring. eDNA can also detect spawning events, although has not been yet tested offshore grounds . Here, we used metabarcoding the presence key fish...

Global change and urbanisation profoundly alter wildlife habitats, driving native animals into novel habitats while increasing the co-occurrence between invasive species. Host-microbiome associations are shaped by host traits environmental features, but little is known about their plasticity in co-occurring species across urban-rural gradients. Here, we explored gut microbiomes of four sympatric small mammal along an ecotone Borneo, one planet's oldest rainforest regions experiencing recent...

The gut microbiota influences human and animal cognition behaviour through its effects on the endocrine immune systems. microbiome–behaviour relationship may be especially relevant for fish, due to their diverse evolutionary history potential implications farming conservation. Yet, there is limited research interaction between microbiome in non-model fish. We manipulated rearing environment diet of fish from two inbred strains self-fertilizing mangrove killifish ( Kryptolebias marmoratus )...

ABSTRACT Global change and urbanisation profoundly alter wildlife habitats, driving native animals into novel habitats while increasing the co‐occurrence between invasive species. Host‐microbiome associations are shaped by host traits environmental features, but little is known about their plasticity in co‐occurring species across urban–rural gradients. Here, we explored gut microbiomes of four sympatric small mammal along an ecotone Borneo, one planet's oldest rainforest regions...

The herbicide linuron is used worldwide, and has been detected in surface waters as well food drinking water. Toxicological studies have reported that acts an antiandrogen vitro vivo disrupts mammalian male reproductive function. However, global mechanisms of toxicity are poorly documented. We RNA-seq to characterize the hepatic transcriptional response mature brown trout exposed for 4 days 1.7, 15.3, 225.9 μg/L linuron. identified a striking decrease expression transcripts encoding majority...

ABSTRACT Background and Objectives The nutritional quality of instant noodles can be improved using dry wet fractionated mungbean protein ingredients. Wheat flour was blended with concentrate isolate to produce high‐protein around 15%, 20%, 25% protein. effects on composition, quality, texture, cooking, color properties were investigated. Findings Significant differences ( p < 0.05) observed in the nutritional, physico‐chemical, functional wheat Water oil holding capacities higher for...