A5006950170- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- IL-33, ST2, and ILC Pathways
- Tracheal and airway disorders
- Dysphagia Assessment and Management
- Immune Cell Function and Interaction
- Voice and Speech Disorders
- Eosinophilic Esophagitis
- Sleep and related disorders
- Neonatal Respiratory Health Research
- Airway Management and Intubation Techniques
- Occupational Therapy Practice and Research
- Sleep and Wakefulness Research
- T-cell and B-cell Immunology
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Child Nutrition and Feeding Issues
- Reproductive System and Pregnancy
- Pediatric health and respiratory diseases
- Vestibular and auditory disorders
- Cardiovascular Syncope and Autonomic Disorders
- Cardiovascular and Diving-Related Complications
- Psychosomatic Disorders and Their Treatments
- Celiac Disease Research and Management
- Ear and Head Tumors
- Energy and Environment Impacts
Uppsala University
2017-2024
Uppsala University Hospital
2019-2023
Keck Graduate Institute
2022
Karolinska Institutet
2008-2020
Karolinska University Hospital
2006-2019
Institute of Immunology
2019
University of Utah
2018
Stockholm South General Hospital
1990-1995
The etiology of upper airway collapsibility in patients with snoring and obstructive sleep apnea (OSA) remains unclear. Local muscular abnormalities, including neurogenic lesions, could be a contributory factor. aim this study was to histologically evaluate the hypothesis progressive snorers disease. Biopsies palatopharyngeal muscle were obtained from 21 habitual different degrees obstruction (10 OSA) 10 nonsnoring control subjects. Morphological signs (e.g., type grouping), blindly...
BackgroundGroup 2 innate lymphoid cells (ILC2s) are involved in the initial phase of type inflammation and can amplify allergic immune responses by orchestrating other cells. Prostaglandin (PG) E2 is a bioactive lipid that plays protective roles lung, particularly during inflammation.ObjectiveWe set out to investigate how PGE2 regulates human ILC2 function.MethodsThe effects on proliferation intracellular cytokine transcription factor expression were assessed means flow cytometry. Cytokine...
<h3>Objective</h3> To assess the 6-month efficacy of uvulopalatopharyngoplasty (UPPP) compared with expectancy in selected patients obstructive sleep apnoea syndrome (OSAS). <h3>Design</h3> A prospective single-centre randomised controlled trial two parallel arms stratified by Friedman stage and body mass index (BMI). <h3>Participants</h3> 65 consecutive moderate to severe OSAS (apnoea-hypopnoea (AHI) ≥15 events/h sleep), BMI <36 kg/m<sup>2</sup>, Epworth sleepiness scale ≥8, I or II....
Tissue-resident memory CD8 + T cells in unexposed oropharyngeal lymphoid tissue exhibit specificity for SARS-CoV-2.
Abstract The Ikaros family of transcription factors (TFs) are important regulators lymphocyte function. However, their roles in human innate lymphoid cell (ILC) function remain unclear. Here, we found that ( IKZF1 ) is expressed by all ILC subsets, including NK cells, blood, tonsil, and gut, while Helios IKZF2 preferentially ILC3 tonsil gut. Aiolos IKZF3 followed the expression pattern T‐bet Eomes, being predominantly ILC1 cells. Differentiation IFN‐γ‐producing cells from IL‐1β plus...
Human innate lymphoid cells have been described to exist in different organs, with functional deregulation of these contributing several disease states. Here, we performed the first detailed characterization phenotype, tissue‐residency properties, and functionality ILC1s, ILC2s, ILC3s human adult fetal liver. In addition, investigated changes ILC compartment liver fibrosis. A unique composition tissue‐resident ILCs was observed nonfibrotic livers as compared that mucosal tissues, NKp44 −...
Adenotonsillectomy (ATE) is one of the most common surgical procedures to treat children with obstructive sleep apnea (OSA), but our knowledge there are no randomized clinical trials confirming benefit surgery compared watchful waiting in between 2 and 4 years age.To determine whether ATE more effective than for treating otherwise healthy mild moderate OSA.This trial was conducted from December 2014 2017 at Otorhinolaryngology Department Karolinska University Hospital, Stockholm, Sweden. A...
Objectives The objective of this study was to longitudinally describe the history tonsil surgery in Swedish children and adolescents regarding incidence, indications for surgery, surgical methods age gender distributions. Setting A retrospective longitudinal population-based cohort based on register data from National Patient Register (NPR) population Statistics Sweden. Participants All 1–<18 years registered NPR with a procedure 1987–2013. Results 167 894 surgeries were An increase total...
Preterm birth (gestational age <37 weeks) has previously been associated with cardiometabolic and neuropsychiatric disorders into adulthood, but seldom examined in relation to sleep disorders. We conducted the first population-based study of preterm sleep-disordered breathing (SDB) from childhood mid-adulthood.A national cohort was all 4 186 615 singleton live births Sweden during 1973-2014, who were followed for SDB ascertained nationwide inpatient outpatient diagnoses through 2015 (maximum...
Innate lymphoid cells (ILCs) are highly plastic and predominantly mucosal tissue-resident that contribute to both homeostasis inflammation depending on the microenvironment. The discovery of naïve-like ILCs suggests an ILC differentiation process is akin naïve T cell differentiation. Delineating mechanisms underlie in tissues crucial for understanding biology health disease. Here, we showed tonsillar expressing CD45RA lacked proliferative activity, indicative cellular quiescence. CD62L...
"Heavy snorer's disease" is defined as progression from heavy snoring to obstructive sleep apnoea syndrome (OSAS). Apart significant weight gain, the aetiology underlying a collapse of upper airways during inspiration and remains unclear. Previous studies have shown that nocturnal respiratory disturbances became worse, even in some OSAS patients who did not gain weight. The patency depends on balance between negative intrapharyngeal pressure developed its counteraction by dilating muscles....
Adenotonsillectomy (ATE) is a well-established and effective treatment of pediatric obstructive sleep apnea (OSA). In recent years, more conservative method, adenotonsillotomy (ATT), has gained popularity because it associated with less postoperative morbidity. Yet no previous randomized study compared these 2 methods regarding their effectiveness in treating OSA terms polysomnographic data, which was the primary aim this study. The hypothesis that ATT noninferior to ATE after 1...
Abstract A local disturbance in the afferent nerves involved reflexogenic dilation of upper airways (UAs) could contribute to increased collapsibility seen patients with obstructive sleep apnea (OSA). Laser Doppler perfusion monitoring, combined electrical stimulation, is a method for investigating nerve regulation microcirculation. It was used mucosa soft palate 35 various degrees UA obstruction and 13 control subjects, all nonsmoking men. In majority snorers mild OSA, stimulation induced...
Objectives:To estimate sibling risk of hospitalization for children with sleep disordered breathing (SDB), diagnosed (1) obstructive apnea syndrome (OSAS), or (2) adenotonsillar hypertrophy in the total Swedish population.
Objectives/Hypothesis Our previous study showed that modified uvulopalatopharyngoplasty (UPPP), including tonsillectomy, significantly improved nocturnal respiration in obstructive sleep apnea syndrome (OSAS) patients. This is a continuous of changes daytime sleepiness and quality life. Study Design Prospective randomized controlled trial (RCT), two parallel arms. Methods Sixty‐five patients with apnea‐hypopnea index ≥ 15, body mass < 36, Epworth Sleepiness Scale (ESS) 8, Friedman stage I...
Abstract Amniotic fluid (AF) surrounds the growing fetus, and cells derived from AF are commonly used for diagnosis of genetic diseases. Intra-amniotic infections strongly linked to preterm birth, which is leading cause perinatal mortality worldwide. Surprisingly little known, however, about mature hematopoietic in AF, could potentially be involved immune responses during pregnancy. In this study, we show that dominating population viable CD45+ represented by a subset fetal CD103+ group 3...