Peter Stärkel
A5012576740- Liver Disease Diagnosis and Treatment
- Alcohol Consumption and Health Effects
- Hepatitis C virus research
- Gut microbiota and health
- Diet and metabolism studies
- Liver Disease and Transplantation
- Hepatitis B Virus Studies
- Organ Transplantation Techniques and Outcomes
- Liver physiology and pathology
- Diet, Metabolism, and Disease
- Tryptophan and brain disorders
- Metabolomics and Mass Spectrometry Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Cytokine Signaling Pathways and Interactions
- Diabetes and associated disorders
- Endoplasmic Reticulum Stress and Disease
- Hepatitis Viruses Studies and Epidemiology
- Pancreatic function and diabetes
- Cancer, Hypoxia, and Metabolism
- Viral gastroenteritis research and epidemiology
- Pancreatitis Pathology and Treatment
- Regulation of Appetite and Obesity
- Drug Transport and Resistance Mechanisms
- HIV/AIDS drug development and treatment
- Cancer-related Molecular Pathways
Cliniques Universitaires Saint-Luc
2016-2025
Directorate-General Joint Research Centre
2021-2025
UCLouvain
2016-2025
University of Turku
2024
Columbia College
2019
Columbia University Irving Medical Center
2019
University of California, San Diego
2019
University of Lausanne
2018
KU Leuven
2010
University Gastroenterology
2004-2010
Significance Alcohol-dependent subjects frequently develop emotional symptoms that contribute to the persistence of alcohol drinking. These are also characterized by gastrointestinal disturbances. In this study, we showed alcohol-dependent with altered intestinal permeability had gut-microbiota composition and activity remained high scores depression, anxiety, craving after a short-term detoxification program. results consistent existence gut–brain axis in dependence, which gut microbiota...
The translocation of bacteria and bacterial products into the circulation contributes to alcoholic liver disease. Intestinal overgrowth is common in patients with aims our study were investigate translocation, changes enteric microbiome, its regulation by mucosal antimicrobial proteins We used a mouse model continuous intragastric feeding alcohol or an isocaloric diet. Bacterial occurred prior observed microbiome. Quantitative intestinal microflora these animals assessed first using...
Summary The disease burden of hepatitis C virus ( HCV ) is expected to increase as the infected population ages. A modelling approach was used estimate total number viremic infections, diagnosed, treated and new infections in 2013. In addition, model change progression mortality 2013–2030. Finally, expert panel consensus capture current treatment practices each country. Using today's paradigm, projected decline or remain flat all countries studied. However, same time period, individuals with...
Chronic liver disease with cirrhosis is the 12th leading cause of death in United States, and alcoholic accounts for approximately half all deaths. alcohol consumption associated intestinal bacterial dysbiosis, yet we understand little about contribution fungi, or mycobiota, to disease. Here have demonstrated that chronic administration increases mycobiota populations translocation fungal β-glucan into systemic circulation mice. Treating mice antifungal agents reduced overgrowth, decreased...
Antimicrobial C-type lectin regenerating islet-derived 3 gamma (REG3G) is suppressed in the small intestine during chronic ethanol feeding. Our aim was to determine mechanism that underlies REG3G suppression experimental alcoholic liver disease.Interleukin 22 (IL-22) regulates expression of REG3G. Therefore, we investigated role IL-22 mice subjected chronic-binge feeding (NIAAA model).In a mouse model disease, found type innate lymphoid cells produce lower levels IL-22. Reduced production...
Intestinal barrier dysfunction is an important contributor to alcoholic liver disease (ALD). Translocated microbial products trigger inflammatory response in the and contribute steatohepatitis. Our aim was investigate mechanisms of disruption after chronic alcohol feeding. A Lieber‐DeCarli model used induce intestinal dysbiosis, increased permeability, mice. Alcohol feeding for 8 weeks induced inflammation jejunum, which characterized by number tumor necrosis factor alpha (TNF‐α)‐producing...
Alcoholic liver disease (ALD) is associated with changes in the intestinal microbiota. Functional consequences of alcohol‐associated dysbiosis are largely unknown. The aim this study was to identify a mechanism how microbiota contribute ALD. Metagenomic sequencing contents demonstrated that chronic ethanol feeding mice an over‐representation bacterial genomic DNA encoding choloylglycine hydrolase, which deconjugates bile acids intestine. Bile acid analysis confirmed increased amount...
The intestinal mucus layer protects the epithelium from noxious agents, viruses, and pathogenic bacteria present in gastrointestinal tract. It is composed of mucins, predominantly mucin (Muc) 2, secreted by goblet cells intestine. Experimental alcoholic liver disease requires translocation bacterial products across barrier into systemic circulation, which induces an inflammatory response contributes to steatohepatitis. We investigated roles layer, particular Muc2, development experimental...
Chronic alcohol consumption causes increased intestinal permeability and changes in the microbiota composition, which contribute to development progression of alcohol-related liver disease. In this setting, little is known about commensal fungi gut. We studied mycobiota a cohort patients with alcoholic hepatitis, use disorder, nonalcoholic controls using fungal-specific internal transcribed spacer amplicon sequencing fecal samples. further measured serum anti-Saccharomyces cerevisiae...
Abstract Alcoholic hepatitis (AH) is a life-threatening condition characterized by profound hepatocellular dysfunction for which targeted treatments are urgently needed. Identification of molecular drivers hampered the lack suitable animal models. By performing RNA sequencing in livers from patients with different phenotypes alcohol-related liver disease (ALD), we show that development AH defective activity liver-enriched transcription factors (LETFs). TGF β 1 key upstream transcriptome...
Summary The number of hepatitis C virus ( HCV ) infections is projected to decline while those with advanced liver disease will increase. A modeling approach was used forecast two treatment scenarios: (i) the impact increased efficacy keeping treated patients constant and (ii) increasing rate. This analysis suggests that successful diagnosis a small proportion can contribute significantly reduction burden in countries studied. largest ‐related morbidity mortality occurs when combined higher...