A5101664612- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Gut microbiota and health
- Liver Disease and Transplantation
- Diet and metabolism studies
- Alcohol Consumption and Health Effects
- Adipose Tissue and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Ginseng Biological Effects and Applications
- Folate and B Vitamins Research
- Birth, Development, and Health
- Reproductive tract infections research
- Colorectal Cancer Screening and Detection
- Gastroesophageal reflux and treatments
- Hepatitis C virus research
- Dietary Effects on Health
- GABA and Rice Research
- Electrolyte and hormonal disorders
- Nerve injury and regeneration
- Syphilis Diagnosis and Treatment
- Cerebrospinal fluid and hydrocephalus
- Neuroscience of respiration and sleep
- Clinical Nutrition and Gastroenterology
- Economic and Financial Impacts of Cancer
University Hospital Cologne
2019-2025
University of Cologne
2019-2025
Robert Bosch (Germany)
2024
Temper (United States)
2024
Hôpital Beaujon
2020
Instituto de Salud Carlos III
2016
Hospital Universitario de Getafe
2014-2016
Centro de Investigación Biomédica en Red de Salud Mental
2016
Instituto de Biomedicina y Biotecnología de Cantabria
2016
Sodercan
2016
Overconsumption of carbohydrates and lipids are well known to cause nonalcoholic fatty liver disease (NAFLD), while the role nutritional protein intake is less clear. In Western diet, meat other animal products main source, with varying concentrations specific amino acids. Whether amount or composition associated a higher risk for severity has not yet been examined. this study, we investigated associations dietary components histological activity by analyzing detailed 14‐day food records in...
Abstract Background and Aim Several studies observed alterations in the gut microbiota patients with non‐alcoholic fatty liver disease (NAFLD). However, analyzed patient populations methods strongly differ among these studies. The aim of this study was to prove reproducibility published results provide a detailed overview all findings our NAFLD cohort using next generation sequencing methods. Methods individual taxonomic composition fecal samples from 90 21 healthy controls 16S rRNA gene...
Several studies show associations between gut bacterial dysbiosis and chronic liver diseases, but causative mechanisms are largely unclear. We recently identified cytolysin, a exotoxin expressed secreted by Enterococcus faecalis to cause damage in the setting of alcohol-related disease. Cytolysin was increased highly correlated with disease severity mortality alcoholic hepatitis patients. In this study, we investigated if faecal cytolysin-positivity can be linked non-alcoholic fatty disease,...
Objectives The management of upper gastrointestinal bleeding (UGIB) has seen rapid advancements with revolutionising innovations. However, insufficient data exist on the necessary number emergency endoscopies needed to achieve competency in haemostatic interventions. Design We retrospectively analysed all oesophagogastroduodenoscopies signs recent haemorrhage performed between 2015 and 2022 at our university hospital. A learning curve was created by plotting previously against treatment...
Abstract Liver fibrosis is the major determinant of liver related complications in patients with non-alcoholic fatty disease (NAFLD). A gut microbiota signature has been explored to predict advanced NAFLD patients. The aim this study was validate and compare diagnostic performance microbiota-based approaches simple non-invasive tools for prediction NAFLD. 16S rRNA gene sequencing performed a cohort 83 biopsy-proven 13 non-invasively diagnosed NAFLD-cirrhosis. Random Forest models based on...
Non-alcoholic fatty liver disease (NAFLD) is a global health burden. Risk factors for severity include older age, increased body mass index (BMI), diabetes, genetic variants, dietary and gut microbiota alterations. However, the interdependence of these their individual impact on remain unknown.In this cross-sectional study, we performed 16S gene sequencing using fecal samples, collected intake, PNPLA3 variants clinical histology parameters in well-described cohort 180 NAFLD patients....
Maternal obesity is associated with an increased risk of hepatic metabolic dysfunction for both mother and offspring targeted interventions to address this growing disease burden are urgently needed. This study investigates whether maternal exercise (ME) could reverse the detrimental effects in obese dams their while focusing on AMP-activated protein kinase (AMPK), representing a key regulator metabolism. In mouse model western-style-diet (WSD)-induced obesity, we established intervention...
Background&Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) is an independent risk factor for cardiovascular morbidity and mortality. Another critical in these patients arterial hypertension (AH). Although it estimated that 50% of MASLD are suffering from AH, 24-h ambulatory blood pressure monitoring (24-h-ABPM), the gold standard diagnosing hypertension, often neglected. However, only 24-h-ABPM can identify subtypes, particularly nocturnal (NH), which a stronger...
Maternal obesity predisposes for hepato-metabolic disorders early in life. However, the underlying mechanisms causing onset dysfunction of liver and metabolism remain elusive. Since is associated with subacute chronic inflammation accelerated aging, we test hypothesis whether maternal induces aging processes developing determines thereby hepatic growth. To this end, was induced high-fat diet (HFD) C57BL/6N mice male offspring were studied at end lactation [postnatal day 21 (P21)]. an obese...
Objective: International guidelines recommend hepatocellular carcinoma (HCC) surveillance with ultrasound in high-risk patients chronic liver diseases. However, there is low-strength evidence about the effects on mortality. The aim of our study was to assess impact clinical course and survival HCC seen at a tertiary referral center Germany.Material methods: We retrospectively evaluated data 401 patients, who presented clinic between 1997 2015. Two groups were compared regarding patient...
…are often invoked as catalytically competent intermediates in oxidative crosscouplings.T his Cover illustrates how two asteroids (CF 3 &Fligands) collide with Venus,traditionally associated to copper, assembling the organocopper(III) fluoride,[ Cu(CF ) F] À (2), which is depicted on surface of planet.In their Communication (e202319412), Julia Contreras-García, Noel Nebra et al. demonstrate key role 2 C-CF bond formation occurring through a2 e redox shuttle.Graphic design by Pablo...
Abstract In western industrialized nations, liver cirrhosis is the most common cause of portal hypertension. Portal hypertension defined by a persistent increase in pressure >7mmHg. An HVPG >10mmHg defines presence clinically significant The (CSPH) patients with key risk factor for transition from compensated to decompensated stage disease. CPSH can be determined invasively measuring HPVG or noninvasively stiffness, platelet count and spleen stiffness. If acute decompensation manifests...
Acute decompensation (AD) in patients with liver cirrhosis is associated a dramatic deterioration prognosis. Immediate initiation of appropriate recompensation measures essential to improve patient's outcome, although objective parameters for evaluating the success are still lacking. Spleen stiffness measurements (SSM) have emerged as promising non-invasive tool assess clinically significant portal hypertension (CSPH), which main driver acute decompensation. However, while SSM accurately...
Objective: Metabolic dysfunction-associated steatotic liver disease (MASLD) and hypertension are major cardiovascular risk factors sharing a bi-directional relationship. Although nearly half of MASLD patients suffering from arterial hypertension, data on the prevalence different phenotypes (e.g. masked hypertension) in this patient population scarce. Masked which is defined by normal office blood pressure but elevated ambulatory 24-hour measurement (24-h-ABPM), often remains undetected,...
A 32-year-old man was referred to our clinic for evaluation of abnormal liver function tests and concurrent proteinuria. Physical examination revealed a maculopapular rash, involving the trunk palms, multiple ‘moth-eaten’ patches alopecia. After prolonged diagnostic work-up hepatitis with concomitant nephrotic syndrome due secondary syphilis diagnosed. Treatment benzylpenicillin led complete clinical recovery. Syphilis is re-emerging infectious disease heterogeneous presentation that should...