Marcin Krawczyk
A5019879976- Liver Disease Diagnosis and Treatment
- Liver Diseases and Immunity
- Liver Disease and Transplantation
- Pediatric Hepatobiliary Diseases and Treatments
- Diet, Metabolism, and Disease
- Gallbladder and Bile Duct Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Drug Transport and Resistance Mechanisms
- Organ Transplantation Techniques and Outcomes
- Endoplasmic Reticulum Stress and Disease
- Diet and metabolism studies
- MicroRNA in disease regulation
- Hepatitis B Virus Studies
- Pancreatitis Pathology and Treatment
- Digestive system and related health
- COVID-19 Clinical Research Studies
- Diabetes and associated disorders
- Pancreatic and Hepatic Oncology Research
- Long-Term Effects of COVID-19
- Extracellular vesicles in disease
- Helicobacter pylori-related gastroenterology studies
- Biliary and Gastrointestinal Fistulas
- Lipid metabolism and disorders
- Alcohol Consumption and Health Effects
- Hepatitis C virus research
University of Duisburg-Essen
2024-2025
Saarland University
2016-2025
Medical University of Warsaw
2016-2025
Essen University Hospital
2025
Universitätsklinikum des Saarlandes
2015-2024
University Medical Center
2006-2024
Gdańsk Medical University
2024
Akademia Tarnowska
2023
Rzeszów University
2023
Clinical Research Consortium
2022
Cholangiocarcinoma (CCA) includes a heterogeneous group of biliary cancers with poor prognosis. Several conditions, such as primary sclerosing cholangitis (PSC), are risk factors. Noninvasive differential diagnosis between intrahepatic CCA and hepatocellular carcinoma (HCC) is sometimes difficult. Accurate noninvasive biomarkers for PSC, CCA, HCC not available. In the search novel biomarkers, serum extracellular vesicles (EV) were isolated from (n = 43), PSC 30), or 29) patients healthy...
Cholangiocarcinoma (CCA) is a rare and heterogeneous biliary cancer, whose incidence related mortality increasing. This study investigates the clinical course of CCA subtypes (intrahepatic [iCCA], perihilar [pCCA], distal [dCCA]) in pan-European cohort.The ENSCCA Registry multicenter observational study. Patients were included if they had histologically proven diagnosis between 2010-2019. Demographic, histomorphological, biochemical, studies performed.Overall, 2,234 patients enrolled...
The PNPLA3 p.I148M, TM6SF2 p.E167K, and MBOAT7 rs641738 variants represent genetic risk factors for nonalcoholic fatty liver disease (NAFLD). Here we investigate if these polymorphisms modulate both steatosis fibrosis in patients with NAFLD. We recruited 515 NAFLD (age 16-88 years, 280 female patients). Liver biopsies were performed 320 patients. PCR-based assays used to genotype the PNPLA3, TM6SF2, variants. Carriers of alleles showed increased serum aspartate aminotransferase alanine...
Objective Homozygous alpha1-antitrypsin (AAT) deficiency increases the risk for developing cirrhosis, whereas relevance of heterozygous carriage remains unclear. Hence, we evaluated impact two most relevant AAT variants (‘Pi*Z’ and ‘Pi*S’), present in up to 10% Caucasians, on subjects with non-alcoholic fatty liver disease (NAFLD) or alcohol misuse. Design We analysed multicentric case–control cohorts consisting 1184 people biopsy-proven NAFLD 2462 chronic misuse, both comprising cases...
Background and Aims Carriage of rs738409:G in patatin‐like phospholipase domain containing 3 ( PNPLA3 ) is associated with an increased risk for developing alcohol‐related cirrhosis hepatocellular carcinoma (HCC). Recently, rs72613567:TA hydroxysteroid 17‐beta dehydrogenase 13 HSD17B13 was shown to be a reduced liver disease attenuate the carriage rs738409:G. This study explores associations between these two genetic variants development HCC. Approach Results Variants were genotyped 6,171...
: Cholangiocarcinoma (CCA) comprises a group of heterogeneous biliary cancers with dismal prognosis. The etiologies most CCAs are unknown, but primary sclerosing cholangitis (PSC) is risk factor. Non-invasive diagnosis CCA challenging and accurate biomarkers lacking. We aimed to characterize the transcriptomic profile serum urine extracellular vesicles (EVs) from patients CCA, PSC, ulcerative colitis (UC), healthy individuals. Serum EVs were isolated by serial ultracentrifugations...
Single-centre studies reported alterations of faecal microbiota in patients with primary sclerosing cholangitis (PSC). As regional factors may affect microbial communities, it is unclear if a signature PSC exists across different geographical regions.To identify robust independent geography and environmental influences.We included 388 individuals (median age, 47 years; range, 15-78) from Germany Norway the study, 137 (n = 75 colitis), 118 ulcerative colitis (UC) 133 healthy controls. Faecal...
Abstract Aims Inflammation plays an important role in cardiovascular disease (CVD) development. The NOD-like receptor protein-3 (NLRP3) inflammasome contributes to the development of atherosclerosis animal models. Components NLRP3 pathway such as interleukin-1β can therapeutically be targeted. Associations genetically determined inflammasome-mediated systemic inflammation with CVD and mortality humans are unknown. Methods results We explored association genetic variants prevalent 538 167...
Background & AimsLimited understanding of pruritus mechanisms in cholestatic liver diseases hinders development antipruritic treatments. Previous studies implicated lysophosphatidic acid (LPA) as a potential mediator pruritus.MethodsPruritogenicity lysophosphatidylcholine (LPC), LPA's precursor, was examined naïve mice, and nonhuman primates. LPC's pruritogenicity involving keratinocyte TRPV4 studied using genetic pharmacologic approaches, cultured keratinocytes, ion channel physiology,...
Objective Despite significant progresses in imaging and pathological evaluation, early differentiation between benign malignant biliary strictures remains challenging. Endoscopic retrograde cholangiopancreatography (ERCP) is used to investigate strictures, enabling the collection of bile. We tested diagnostic potential next-generation sequencing (NGS) mutational analysis bile cell-free DNA (cfDNA). Design A prospective cohort patients with suspicious (n=68) was studied. The performance...
Abkürzungsverzeichnis AASLD: American Association for the Study of Liver Diseases AFP: Alpha-Fetoprotein ALD: Alcoholic Diesease ALT: Alaninaminotransferase APASL: Asian Pacific APRI: AST/platelet ratio ASH: Steatohepatitis ATI: Attenuation Imaging AUC: Area Under Curve AUROC: Receiver Operating Characteristic BMI: Body Mass Index CAP: Controlled Parameter CDT: Carbohydrate-Deficient Transferrin CT: Computertomographie DECT: Dual-Energy CT DPP4: Dipeptidyl Peptidase 4 EASL : European ELF:...
We previously identified subsets of patients with NAFLD different metabolic phenotypes. Here we align metabolomic signatures cardiovascular disease (CVD) and genetic risk factors.
Abstract Despite decades of research, the pathogenesis metabolic dysfunction‐associated steatotic liver disease (MASLD) is still not completely understood. Based on evidence from preclinical models, one factors proposed as a main driver development oxidative stress. This study aimed to search for resemblance between profiles stress and antioxidant defense in animal model MASLD group patients. C57BL/6J mice were fed with Western diet up 24 weeks served MASLD. The profile hepatic tissue was...