A5021062085- Liver Disease Diagnosis and Treatment
- Alcohol Consumption and Health Effects
- Liver Disease and Transplantation
- Diet, Metabolism, and Disease
- Iron Metabolism and Disorders
- Trace Elements in Health
- Hepatocellular Carcinoma Treatment and Prognosis
- Endoplasmic Reticulum Stress and Disease
- Liver Diseases and Immunity
- Heme Oxygenase-1 and Carbon Monoxide
- Hemoglobinopathies and Related Disorders
- Liver physiology and pathology
- Eicosanoids and Hypertension Pharmacology
- Adipose Tissue and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Pancreatitis Pathology and Treatment
- Lipid metabolism and biosynthesis
- Organ Transplantation Techniques and Outcomes
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Substance Abuse Treatment and Outcomes
- MicroRNA in disease regulation
- Ultrasound Imaging and Elastography
- Cancer, Hypoxia, and Metabolism
- Animal Virus Infections Studies
Heidelberg University
2016-2025
University Hospital Heidelberg
2009-2024
University Hospital of Basel
2016-2024
Imperial College London
2024
Schulthess-Klinik
2024
Universitätsklinik Balgrist
2024
University Hospital of Bern
2024
Solothurner Spitäler
2024
Charité - Universitätsmedizin Berlin
2024
Heidelberg University
2012-2022
Abstract Transient elastography (FibroScan [FS]) is a novel non-invasive tool to assess liver fibrosis/cirrhosis. However, it remains be determined if other diseases such as extrahepatic cholestasis interfere with fibrosis assessment because stiffness indirectly measured by the propagation velocity of an ultrasound wave within liver. In this study, we immediately before endoscopic retrograde cholangiopancreatography and 3 12 days after successful biliary drainage in patients mostly due...
To test if inflammation also interferes with liver stiffness (LS) assessment in alcoholic disease (ALD) and to provide a clinical algorithm for reliable fibrosis ALD by FibroScan (FS).We first performed sequential LS analysis before after normalization of serum transaminases learning cohort 50 patients admitted alcohol detoxification. decreased almost all within mean observation interval 5.3 d. Six (12%) would have been misdiagnosed F3 F4 but below critical cut-off values 8 12.5 kPa...
Oxidative stress is thought to play a major role in the pathogenesis of hepatocellular cancer (HCC), frequent complication alcoholic liver disease (ALD). However, underlying mechanisms are poorly understood. In hepatocytes ALD patients, we recently detected by immunohistochemistry significantly increased levels carcinogenic etheno-DNA adducts that formed reaction lipid peroxidation product, 4-hydroxynonenal (4-HNE) with nucleobases. current study, show protein-bound 4-HNE and both strongly...
Objective Alcohol-related pancreatitis is associated with a disproportionately large number of hospitalisations among GI disorders. Despite its clinical importance, genetic susceptibility to alcoholic chronic (CP) poorly characterised. To identify risk genes for CP and evaluate their relevance in non-alcoholic CP, we performed genome-wide association study functional characterisation new locus. Design 1959 European patients population-based controls from the KORA, LIFE INCIPE studies...
Abstract Background & Aims It is well known that inflammation increases liver stiffness ( LS ) in patients with chronic hepatitis C HCV and alcoholic disease ALD independent of fibrosis stage, but no inflammation‐adapted cut‐off values have been settled so far. An early identification rapid fibrosers, however, essential to decide whom treat first the novel expensive antiviral drugs. Methods Liver stiffness, biopsy‐proven stages F0–F4 METAVIR or Kleiner score) routine laboratory...
Background and Aims Carriage of rs738409:G in patatin‐like phospholipase domain containing 3 ( PNPLA3 ) is associated with an increased risk for developing alcohol‐related cirrhosis hepatocellular carcinoma (HCC). Recently, rs72613567:TA hydroxysteroid 17‐beta dehydrogenase 13 HSD17B13 was shown to be a reduced liver disease attenuate the carriage rs738409:G. This study explores associations between these two genetic variants development HCC. Approach Results Variants were genotyped 6,171...
We have studied the responses of iron regulatory protein-1 (IRP-1) to extra- and intracellular sources reactive oxygen intermediates (ROIs). IRP-1 is a cytoplasmic RNA-binding protein that regulates metabolism following its activation by deficiency, nitric oxide, administration H2O2 or antimycin A, an inhibitor respiratory chain (Hentze, M. W., Kühn, L. C. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 8175-8182). show 10 μM suffice for complete within 60 min when generated extracellularly at...
It is unknown whether transforming growth factor beta1 (TGF-beta1) signaling uniformly participates in fibrogenic chronic liver diseases, irrespective of the underlying origin, or if other cytokines such as interleukin (IL)-13 share fibrogenesis (e.g., due to regulatory effects on type I pro-collagen expression). TGF-beta1 events were scored 396 tissue samples from patients with diverse including hepatitis B virus (HBV), C (HCV), Schistosoma japonicum infection, and...
LBA3506 The full, final text of this abstract will be available at abstract.asco.org 7:30 AM (EDT) on Saturday June, 1, 2013, and in the Annual Meeting Proceedings online supplement to June 20, issue Journal Clinical Oncology. Onsite Meeting, printed edition ASCO Daily News.