A5066537961- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatitis Pathology and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Neuroendocrine Tumor Research Advances
- Photodynamic Therapy Research Studies
- Gastrointestinal disorders and treatments
- Nanoplatforms for cancer theranostics
- Biliary and Gastrointestinal Fistulas
- Liver Diseases and Immunity
- Liver Disease Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Colorectal Cancer Screening and Detection
- IgG4-Related and Inflammatory Diseases
- Gastric Cancer Management and Outcomes
- Angiogenesis and VEGF in Cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Immunotherapy and Biomarkers
- Esophageal and GI Pathology
- Radiomics and Machine Learning in Medical Imaging
- Liver Disease and Transplantation
- Hormonal Regulation and Hypertension
- Cancer, Hypoxia, and Metabolism
- Genetic factors in colorectal cancer
University College London
2016-2025
University College Hospital
2014-2025
University College London Hospitals NHS Foundation Trust
2015-2025
Curtin University
2025
Wellcome / EPSRC Centre for Interventional and Surgical Sciences
2024
The Royal Free Hospital
2014-2023
Roland Hill (United Kingdom)
2013-2023
SUNY College of Optometry
2022
Institute for Liver Health
2015-2021
Royal London Hospital
2002-2021
There is no established standard chemotherapy for patients with locally advanced or metastatic biliary tract cancer. We initially conducted a randomized, phase 2 study involving 86 to compare cisplatin plus gemcitabine alone. After we found an improvement in progression-free survival, the trial was extended 3 reported here.We randomly assigned 410 cholangiocarcinoma, gallbladder cancer, ampullary cancer receive either (25 mg per square meter of body-surface area) followed by (1000 on days 1...
The British Society of Gastroenterology guidelines on the management cholangiocarcinoma were originally published in 2002. This is first update since then and based a comprehensive review recent literature, including data from randomised controlled trials, systematic reviews, meta-analyses, cohort, prospective retrospective studies.
2 or 3 studies; D=level 5 evidence inconsistent inconclusive studies of any level.
Automatic segmentation of abdominal anatomy on computed tomography (CT) images can support diagnosis, treatment planning, and delivery workflows. Segmentation methods using statistical models multi-atlas label fusion (MALF) require inter-subject image registrations, which are challenging for images, but alternative without registration have not yet achieved higher accuracy most organs. We present a registration-free deep-learning-based algorithm eight organs that relevant navigation in...
Patients with pancreatic cancer have a poor prognosis apart from the few suitable for surgery. Photodynamic therapy (PDT) produces localised tissue necrosis but previous studies using photosensitiser meso-tetrahydroxyphenylchlorin (mTHPC) caused prolonged skin photosensitivity. This study assessed shorter acting photosensitiser, verteporfin. Fifteen inoperable patients locally advanced cancers were sensitised 0.4 mg kg−1 After 60–90 min, laser light (690 nm) was delivered via single (13...
<h3>Objectives</h3> Serous cystic neoplasm (SCN) is a of the pancreas whose natural history poorly known. The purpose study was to attempt describe SCN, including specific mortality. <h3>Design</h3> Retrospective multinational SCN diagnosed between 1990 and 2014. <h3>Results</h3> 2622 patients were included. Seventy-four per cent women, median age at diagnosis 58 years (16–99). Patients presented with non-specific abdominal pain (27%), pancreaticobiliary symptoms (9%), diabetes mellitus...
Primary biliary cholangitis (formerly known as primary cirrhosis, PBC) is an autoimmune liver disease in which a cycle of immune mediated epithelial cell injury, cholestasis and progressive fibrosis can culminate over time end-stage cirrhosis. Both genetic environmental influences are presumed relevant to initiation. PBC most prevalent women those the age 50, but spectrum recognised adult patients globally; male sex, younger at onset (<45) advanced presentation baseline predictors poorer...
Type I autoimmune pancreatitis (AIP) and IgG4-related sclerosing cholangitis (IgG4-related SC) are now recognized as components of a multisystem disease (IgG4-RD). We aimed to define the clinical course long-term outcomes in patients with AIP/IgG4-SC recruited from two large UK tertiary referral centers.
MAIN RECOMMENDATIONS 1 ESGE/EASL recommend that, as the primary diagnostic modality for PSC, magnetic resonance cholangiography (MRC) should be preferred over endoscopic retrograde cholangiopancreatography (ERCP). Moderate quality evidence, strong recommendation. 2 suggest that ERCP can considered if MRC plus liver biopsy is equivocal or contraindicated in patients with persisting clinical suspicion of PSC. The risks have to weighed against potential benefit regard surveillance and treatment...
These guidelines on the management of primary sclerosing cholangitis (PSC) were commissioned by British Society Gastroenterology liver section. The guideline writing committee included medical representatives from hepatology and gastroenterology groups as well patient PSC Support. aim to support general physicians, gastroenterologists surgeons in managing adults with or those presenting similar cholangiopathies which may mimic PSC, such IgG4 cholangitis. It also acts a reference for patients...
Abstract Purpose: Noninvasive biomarkers for early detection of pancreatic ductal adenocarcinoma (PDAC) are currently not available. Here, we aimed to identify a set urine proteins able distinguish patients with early-stage PDAC from healthy individuals. Experimental design: Proteomes 18 samples controls, chronic pancreatitis, and (six/group) were assayed using GeLC/MS/MS analysis. The selected subsequently validated ELISA assays multiple logistic regression applied training dataset in...
Dominant biliary strictures occur commonly in patients with primary sclerosing cholangitis (PSC), who have a high risk of developing cholangiocarcinoma (CC). The natural history and optimal management dominant remain unclear, some reports suggesting that endoscopic interventions improve outcome.We describe 25-year experience PSC-related at single tertiary referral centre.A total 128 PSC (64% men, mean age 49 years) were followed for 9.8 years. Eighty (62.5%) had median 3 (range 0-34)...
Biomarkers for the early detection of pancreatic cancer are urgently needed. The primary objective this study was to evaluate whether increased levels serum CA19-9, CA125, CEACAM1, and REG3A present before clinical presentation assess performance combined markers prognosis.This nested case-control within UKCTOCS included 118 single 143 serial samples from 154 postmenopausal women who were subsequently diagnosed with 304 matched noncancer controls. Samples split randomly into independent...
OBJECTIVE Most cases of autoimmune pancreatitis (AIP) have been reported from Japan. We present data on a UK series, including clinical and radiological features at presentation, longitudinal response to immunosuppression. METHODS Over an 18-month period, all patients diagnosed in our center with AIP were studied. Endoscopic biliary stenting was performed as required, treated prednisolone, assessed longitudinally. In disease relapse following steroid reduction, azathioprine instituted....
Necrosis of tumor cells can activate both innate and adaptive antitumor immunity. However, there is little information on the effects necrosis-inducing cancer treatments tumor-specific T cell immune responses in humans. We studied a treatment (embolization) anti-alpha-fetoprotein (AFP)-specific CD4(+) hepatocellular carcinoma (HCC) patients controls using an array AFP-derived peptides. In this study, we show that AFP-specific to three immunodominant epitopes HCC were significantly expanded...