A5016731047- Colorectal Cancer Surgical Treatments
- Pancreatic and Hepatic Oncology Research
- Colorectal and Anal Carcinomas
- Anorectal Disease Treatments and Outcomes
- Diverticular Disease and Complications
- Gastric Cancer Management and Outcomes
- Intraperitoneal and Appendiceal Malignancies
- Pancreatitis Pathology and Treatment
- Hernia repair and management
- Neuroblastoma Research and Treatments
- Pelvic floor disorders treatments
- Appendicitis Diagnosis and Management
- Cancer Genomics and Diagnostics
- Colorectal Cancer Screening and Detection
- Neuroendocrine Tumor Research Advances
- Colorectal Cancer Treatments and Studies
- Intestinal and Peritoneal Adhesions
- Hepatocellular Carcinoma Treatment and Prognosis
- Gallbladder and Bile Duct Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer Research and Treatments
- Enhanced Recovery After Surgery
- Histone Deacetylase Inhibitors Research
- Gastrointestinal disorders and treatments
Centre Hospitalier Universitaire de Tours
2016-2025
Hôpital Bretonneau
2016-2024
Université de Tours
2017-2024
Thion Medical (France)
2017-2024
Martin-Luther-Krankenhaus
2023
Sorbonne Université
2018-2022
Hôpital Armand-Trousseau
2019-2022
University of Münster
2022
Institut thématique Immunologie, inflammation, infectiologie et microbiologie
2022
Hôpital de la Timone
2010-2021
Significance Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second deadliest cancer by 2030. Advances in therapeutic treatments are urgently required fight against this fatal disease. Here, elucidation of metabolic signature PDAC has identified low-density lipoprotein receptor (LDLR), which facilitates cholesterol uptake, as a promising target. Blocking LDLR reduces proliferative and clonogenic potential cells decreases activation ERK1/2 survival pathway. Moreover,...
<h3>Objectives</h3> Serous cystic neoplasm (SCN) is a of the pancreas whose natural history poorly known. The purpose study was to attempt describe SCN, including specific mortality. <h3>Design</h3> Retrospective multinational SCN diagnosed between 1990 and 2014. <h3>Results</h3> 2622 patients were included. Seventy-four per cent women, median age at diagnosis 58 years (16–99). Patients presented with non-specific abdominal pain (27%), pancreaticobiliary symptoms (9%), diabetes mellitus...
The intratumoral microenvironment, or stroma, is of major importance in the pathobiology pancreatic ductal adenocarcinoma (PDA), and specific conditions stroma may promote increased cancer aggressiveness. We hypothesized that this heterogeneous evolving compartment drastically influences tumor cell abilities, which turn PDA aggressiveness through crosstalk mediated by extracellular vesicles (EVs). Here, we have analyzed proteomic stromal signature identified a contribution annexin A6/LDL...
Preclinical models based on patient-derived xenografts have remarkable specificity in distinguishing transformed human tumor cells from non-transformed murine stromal computationally. We obtained 29 pancreatic ductal adenocarcinoma (PDAC) either resectable or non-resectable patients (surgery and endoscopic ultrasound-guided fine-needle aspirate, respectively). Extensive multiomic profiling revealed two subtypes with distinct clinical outcomes. These uncovered specific alterations DNA...
Pancreatic ductal adenocarcinoma (PDAC) is characterized by extensive stroma and pathogenic modifications to the peripheral nervous system that elevate metastatic capacity. In this study, we show IL6-related stem cell-promoting factor LIF supports PDAC-associated neural remodeling (PANR). was overexpressed in tumor tissue compared with healthy pancreas, but its receptors LIFR gp130 were expressed only intratumoral nerves. Cancer cells stromal PDAC tissues both LIF, could secrete it....
Abstract Aim Alteration of bowel function after delayed coloanal anastomosis (DCAA) might be a limitation to its utilization. Our aim was assess the long‐term DCAA in large multicentric cohort. Method All patients who underwent interventions at 29 GRECCAR‐affiliated hospitals between 2010 and 2021 were retrospectively included. Low anterior resection syndrome (LARS) score or confection stoma due poor assessed eligible patients. Good defined by preservation continuity with no LARS minor LARS....
Abstract Background Bile duct injury (BDI) remains the most serious complication of laparoscopic cholecystectomy (LC). A Swiss database was used to identify risk factors for BDI and assess effect intraoperative cholangiography (IOC). Methods Data patients from 114 institutions who underwent LC acute or chronic cholecystitis between 1995 2005 were in univariable logistic regression analyses. Results In total 31 838 patients, mean(s.d.) age 54·4(15·9) years, analysed. The incidence 0·3 per...
Designing multitarget drugs have raised considerable interest due to their advantages in the treatment of complex diseases such as cancer. Their design constitutes a challenge antitumor drug discovery. The present study reports dual inhibition tubulin polymerization and HDAC activity. On basis 1,1-diarylethylenes ( isoCA-4) belinostat, series hybrid molecules was successfully designed synthesized. In particular compounds, 5f 5h were proven be potent inhibitors both HDAC8 leading excellent...
Research Article8 March 2017Open Access Source DataTransparent process Gene expression profiling of patient-derived pancreatic cancer xenografts predicts sensitivity to the BET bromodomain inhibitor JQ1: implications for individualized medicine efforts Benjamin Bian orcid.org/0000-0001-8691-5292 Centre de Recherche en Cancérologie Marseille (CRCM), INSERM U1068, CNRS UMR 7258, Parc Scientifique et Technologique Luminy, Aix-Marseille Université and Institut Paoli-Calmettes, Marseille, France...
Abstract Pancreatic ductal adenocarcinoma (PDA) is a critical health issue in the field of cancer, with few therapeutic options. Evidence supports an implication intratumoral microenvironment (stroma) on PDA progression. However, its contribution to role neuroplastic changes within pathophysiology and clinical course PDA, through tumor recurrence neuropathic pain, remains unknown, neglecting putative, window. Here, we report that mediator PDA-associated neural remodeling (PANR), highlight...
Microparticles are plasma membrane vesicles produced by apoptotic or activated cells and resting cancer cells. The concentration, origin procoagulant properties of circulating microparticles reported to differ according pathological settings (inflammation, cardiovascular diseases). In case cancer, different studies have a variation in the concentration microparticles, with an increase tumor-associated antigen-bearing microparticles. However, specificity these results remains unknown....
Patients with recurrent malignant epithelioid mesothelioma (MM) after surgery and standard chemotherapy cisplatin pemetrexed have limited treatment options. We performed a retrospective cohort study of patients MM undergoing Pressurized IntraPeritoneal/Thoracal Aerosol Chemotherapy (PIPAC/PITAC) doxorubicin 1.5 mg/m2 7.5 mg/m2. Data were retrospectively collected in prospective registry PIPAC/PITAC. Study outcomes microscopic tumor regression grade (TRG), survival adverse events (v4.0...
Aim Sacral nerve stimulation (SNS) has a place in the treatment algorithm for faecal incontinence (FI). However, after implantation, 15–30% of patients with FI fail to respond unknown reasons. We investigated effect SNS on continence and quality life (QOL) tried identify specific predictive factors success permanent FI. Method Two hundred consecutive (six men; median age = 60; range 16–81) underwent implantation The severity was evaluated by Cleveland Clinic Score. Quality French version...
Alteration in intestinal permeability is the main factor underlying pathogenesis of many diseases affecting gut, such as inflammatory bowel disease [IBD]. Characterization molecules targeting restoration barrier integrity therefore vital for development alternative therapies. The yeast Saccharomyces boulardii CNCM I-745 [Sb], used to prevent and treat antibiotic-associated infectious functional diarrhea, may have a beneficial effect treatment IBD. We analyzed impact Sb supernatant on tissue...
Objectives Ampullary carcinoma is a rare tumor. There are neither sufficient available data related to management after resection of the neoplasm ampulla Vater, nor any international recommendations. The aim this study was identify factors associated with recurrence and survival curative resection. Methods A retrospective follow-up conducted including patients ampullary who underwent intent in 12 French surgical centers between January 1990 November 2011. Results In study, 319 for an...
BACKGROUND: The optimal elective colectomy in patients with splenic flexure tumor is debated. OBJECTIVE: This study aimed to compare colectomy, left hemicolectomy, and subtotal for perioperative, histological, survival outcomes this setting. DESIGN: a multicenter retrospective cohort study. SETTING: Patients diagnosed nonmetastatic who underwent were included. PATIENTS: Between 2006 2014, 313 consecutive operated on 15 French Research Group of Rectal Cancer Surgery centers. INTERVENTIONS:...