A5103250651- Photodynamic Therapy Research Studies
- Porphyrin and Phthalocyanine Chemistry
- Nanoplatforms for cancer theranostics
- Lipid Membrane Structure and Behavior
- Analytical Chemistry and Chromatography
- Electrohydrodynamics and Fluid Dynamics
- Drug Solubulity and Delivery Systems
- Cancer, Hypoxia, and Metabolism
- Molecular Sensors and Ion Detection
- Synthetic Organic Chemistry Methods
- Protein purification and stability
- Porphyrin Metabolism and Disorders
- Analytical Chemistry and Sensors
- Surfactants and Colloidal Systems
- Spectroscopy Techniques in Biomedical and Chemical Research
- Supramolecular Chemistry and Complexes
- Neonatal Health and Biochemistry
- Electrostatics and Colloid Interactions
- Microbial Natural Products and Biosynthesis
- Protein Degradation and Inhibitors
- Receptor Mechanisms and Signaling
- Polymer Surface Interaction Studies
- Photochromic and Fluorescence Chemistry
- Ocular Oncology and Treatments
- Histone Deacetylase Inhibitors Research
Université Paris-Saclay
2001-2022
Laboratoire COBRA
1998-2020
Université Paris-Sud
1999-2020
Institut Galien Paris-Saclay
1993-2017
Centre National de la Recherche Scientifique
1993-2012
Université Toulouse III - Paul Sabatier
2012
Laboratoire de Phonétique et Phonologie
2002-2011
Université Paris Cité
1993-2006
Institut Curie
2003-2004
Laboratoire de Chimie
1999
Designing multitarget drugs have raised considerable interest due to their advantages in the treatment of complex diseases such as cancer. Their design constitutes a challenge antitumor drug discovery. The present study reports dual inhibition tubulin polymerization and HDAC activity. On basis 1,1-diarylethylenes ( isoCA-4) belinostat, series hybrid molecules was successfully designed synthesized. In particular compounds, 5f 5h were proven be potent inhibitors both HDAC8 leading excellent...
We report the synthesis and metabolic biological evaluation of a series 17 novel heterocyclic derivatives isocombretastatin-A4 (iso-CA-4) their structure-activity relationships. Among these derivatives, most active compound, 4f, inhibited growth panel seven cancer cell lines with an IC50 in low nanomolar range. In addition, 4f showed interesting activity against CA-4-resistant colon-carcinoma cells multidrug-resistant leukemia cells. It also induced G2/M cell-cycle arrest. Structural data...
In this paper, we discuss the evolution over last 15 years in Curie Institute of concept, development design and some properties glycoconjugated photosensitizers with aim to optimize tumor targeting photodynamic therapy. By research, have shown that specific interactions between a mannose-lectin trimannosylglycodendrimeric porphyrins contributed larger extent than non-specific ones overall interaction glycosylated tetraarylporphyrin membrane. The studies vitro photocytotoxicity showed...
In photodynamic therapy, the specificity of a photosensitizer and its penetration into tumor cells are crucial. We have analyzed ability newly synthesized meso-(tetraphenyl)porphyrins to be recognized by model mannose-specific proteins overexpressed at surface retinoblastoma cells. The specific interaction porphyrin with Con A was studied pressure measurements, fluorescence spectroscopy, dynamic light scattering, QCM-D. extent porphyrins binding highly dependent upon their chemical...
Photodynamic therapy (PDT) is considered one efficient treatment against retinoblastoma. The specificity of a photosensitizer and its penetration into cancerous cells are crucial for achieving tumor necrosis. selection photosensitizers such as porphyrin derivatives by thus depends to large extent on their ability interact with the biological membrane. In this work, we have studied surface pressure measurements fluorescence spectroscopy interaction between three newly synthesized dendrimeric...
The use of porphyrin derivatives in photodynamic therapy is excellent prospect for the treatment superficial or easily reachable tumors. selection by tumor cells depends to a large extent their ability interact with biological membrane. evaluation interaction phospholipids can thus be used as screening method. In this work we report on assessment three new various forming Langmuir films surface tension and pressure measurements, grazing incidence X-ray diffraction, liquid chromatography an...
Abstract The capacity of two types amphiphilic β-cyclodextrin (CD) derivatives, heptakis-C6-alkylamido β-CD (I) and heptakis-C6-ammonium tetradecakis-O2,O3-alkyl (II), to form organized assemblies with l α-phosphatidylcholine-dipalmitoyl (dppc) iotacarrageenan is described. These systems are studied using a Langmuir balance. formation stable mixed layers between I II dppc observed. interaction iota-carrageenan leads dimunition in the fluidity monomolecular layers. physicochemical properties...
Abstract The mefa‐tetra(hydroxyphenyl)chlorin (m‐THPC), a second‐generation sensitizer used in photodynamic therapy (PDT), is currently under clinical trial. In vivo fluorom‐etry provides direct evidence that photobleaching processes are induced at the tumor site during PDT. Pho‐toproduct formation has thus to be taken into account fully understand PDT treatment. A preliminary step determine fluorescence characteristics of photo‐products formed solution. Solutions m‐THPC irradiated 514 nm...
Fluorescence properties of 5,10,15,20-tetra( m-hydroxyphenyl)chlorin ( m-THPC), a sensitizer used in photodynamic therapy (PDT), were studied the presence three native cyclodextrins (CDs) -α, -β, and γ-CD—and two modified cyclodextrins—heptakis (2,6-di- O-methyl) β-CD (Me-β-CD) heptakis (2- O-hydroxy-propyl) (HP-β-CD). The CDs have been shown to undergo formation an inclusion complex with m-THPC, leading large enhancement (up 300 times) m-THPC fluorescence intensity depending on CD used....