A5086256410- Nanoparticle-Based Drug Delivery
- Iron oxide chemistry and applications
- Advancements in Transdermal Drug Delivery
- Spectroscopy Techniques in Biomedical and Chemical Research
- Characterization and Applications of Magnetic Nanoparticles
- Protein Interaction Studies and Fluorescence Analysis
- Gold and Silver Nanoparticles Synthesis and Applications
- Advanced Drug Delivery Systems
- Proteins in Food Systems
- Microencapsulation and Drying Processes
- RNA Interference and Gene Delivery
- Synthetic Organic Chemistry Methods
- Analytical Chemistry and Chromatography
- Graphene and Nanomaterials Applications
- Analytical Chemistry and Sensors
- Lipid Membrane Structure and Behavior
- Advanced biosensing and bioanalysis techniques
- Intraperitoneal and Appendiceal Malignancies
- Skin Protection and Aging
- Lanthanide and Transition Metal Complexes
- Histone Deacetylase Inhibitors Research
- Dermatologic Treatments and Research
- Curcumin's Biomedical Applications
- Click Chemistry and Applications
- Protein Degradation and Inhibitors
Université de Tours
2012-2025
Centre National de la Recherche Scientifique
2010-2025
Centre de Biophysique Moléculaire
2025
Nanomed (Brazil)
2016-2023
Université Paris-Saclay
2018-2022
Université Paris-Sud
2018
Institut d'Imagerie Biomédicale
2007-2011
Université d'Orléans
2010
Interfaces, Confinement, Matériaux et Nanostructures
2010
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2010
The chemical and structural properties of ferrite-based nanoparticles, precursors for magnetic drug targeting, have been studied by Raman confocal multispectral imaging. nanoparticles were synthesised as aqueous fluids co-precipitation ferrous ferric salts. Dehydrated particles corresponding to (CP) oxidation (OX) steps the fluid preparation compared in order establish oxidation-related features. These are discussed correlation with spectra bulk iron oxides (magnetite, maghemite hematite)...
We report the efficient one-step synthesis and detailed physicochemical evaluation of novel biocompatible nanosystems useful for cancer therapeutics diagnostics (theranostics). These systems are superparamagnetic iron oxide nanoparticles (SPIONs) carrying anticancer drug doxorubicin coated with covalently bonded polymer poly(ethylene glycol) (PEG), native modified biological targeting ligand folic acid (PEG-FA). multifunctional (SPION-DOX-PEG-FA) designed to rationally combine multilevel...
We report here the development of stable aqueous suspensions biocompatible superparamagnetic iron oxide nanoparticles (SPIONs). These so-called ferrofluids are useful in a large spectrum modern biomedical applications, including novel diagnostic tools and targeted therapeutics. In order to provide prolonged circulation times for vivo, initial were coated with polymer poly(ethylene glycol) (PEG). To permit covalent bonding PEG SPION surface, latter was functionalized coupling agent,...
The present work depicts the efficient one-step synthesis and detailed evaluation of stable aqueous colloids silver nanoparticles (NPs) coated with poly(ethylene glycol) (PEG) covalently attached to their surface. Due steric repulsion between polymer-modified surfaces, stability nanoparticle suspension was preserved even at high ionic strength (0.1 M NaCl). At same time, PEG coating remains sufficiently permeable allow surface-enhanced Raman scattering (SERS) from micromolar concentrations...
Designing multitarget drugs have raised considerable interest due to their advantages in the treatment of complex diseases such as cancer. Their design constitutes a challenge antitumor drug discovery. The present study reports dual inhibition tubulin polymerization and HDAC activity. On basis 1,1-diarylethylenes ( isoCA-4) belinostat, series hybrid molecules was successfully designed synthesized. In particular compounds, 5f 5h were proven be potent inhibitors both HDAC8 leading excellent...
We report the synthesis and metabolic biological evaluation of a series 17 novel heterocyclic derivatives isocombretastatin-A4 (iso-CA-4) their structure-activity relationships. Among these derivatives, most active compound, 4f, inhibited growth panel seven cancer cell lines with an IC50 in low nanomolar range. In addition, 4f showed interesting activity against CA-4-resistant colon-carcinoma cells multidrug-resistant leukemia cells. It also induced G2/M cell-cycle arrest. Structural data...
We report a one-pot synthesis protocol for highly efficient and stable covalent binding of both the fluorescent drug doxorubicin (DOX) biocompatible polymer poly(ethylene glycol) (PEG) to surface superparamagnetic iron oxide nanoparticles (SPIONs). The final aim is obtain biocompatible, injectable nanosystem combining anticancer activity (magnetically targeted delivery) nondestructive imaging treated cancer cells tissues by means fluorescence magnetic resonance (MRI). Our employs silane...
The cutaneous penetration of hydrophobic active molecules is foremost concern in the dermatology and cosmetic formulation fields. poor solubility water those limits their use hydrophilic forms such as gels, which are favored by patients with chronic skin disease. aim this work to design a novel nanocarrier determine its potential an ingredient topical form. consists oily core surrounded protective shell alginate, natural polysaccharide isolated from brown algae. These calcium alginate-based...
The use of small interfering RNA (siRNA) to regulate oncogenes appears as a promising strategy in the context cancer therapy, especially if they are vectorized by smart delivery system. In this study, we investigated cellular trafficking siRNA nanovector (called CS-MSN) functionalized with cell-penetrating peptide gH625 triple-negative breast model. With complementary techniques, showed that nanovectors were internalized both clathrin- and caveolae-mediated endocytosis. presence at surface...
Abstract Objective Increasing consumer demand for natural and environmentally friendly products is driving the cosmetic industry to seek greener safer processes. High‐frequency ultrasound technology (HFUT) stabilizes emulsions without adding emulsifying surfactants (ES). In this work, formulation characteristics of an HFUT‐treated emulsion a Reference were compared both caffeine α‐tocopherol. Methods A comparison was made between ES‐free based on droplet size, viscosity, pH rheology...
Background: Chinese hamster ovary (CHO) cell metabolism is complex, influenced by nutrients like glucose and glutamine metabolites such as lactate. Real-time monitoring necessary for optimizing culture conditions ensuring consistent product quality. Raman spectroscopy has emerged a robust process analytical technology (PAT) tool due to its non-invasive, in situ capabilities. This study evaluates key metabolic parameters IgG titer CHO cultures. Methods: was applied five 10 L-scale Partial...
Increase of lipophilicity cationic doxorubicin (DOX) by its association with a fatty acid ion is interest for pharmaceutical formulations and could have an impact on the drug delivery into cancer cells. On basis spectroscopic analysis intrinsic DOX fluorescence, this study provides experimental evidence DOX–oleate interactions as function ion/drug molar ratio (R) pH. An electrostatic attraction to oleates dominant form (pH 6.5) hydrophobic interaction characteristic molecular 8.6). A high...
Confocal Raman microscopy (CRM) has become a versatile technique that can be applied routinely to monitor skin penetration of active molecules. In the present study, CRM coupled multivariate analysis (namely PLSR-partial least squares regression) is used for quantitative measurement an ingredient (AI) isolated (ex vivo) human stratum corneum (SC), using systematically varied doses resorcinol, as model compound, and performance quantified according key figures merit defined by regulatory...