A5075939022- Blood Coagulation and Thrombosis Mechanisms
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Hemophilia Treatment and Research
- Platelet Disorders and Treatments
- Phagocytosis and Immune Regulation
- Venous Thromboembolism Diagnosis and Management
- Erythrocyte Function and Pathophysiology
- Sepsis Diagnosis and Treatment
- Heparin-Induced Thrombocytopenia and Thrombosis
- Vitamin K Research Studies
- Protease and Inhibitor Mechanisms
- Pancreatitis Pathology and Treatment
- Glycosylation and Glycoproteins Research
- S100 Proteins and Annexins
- Complement system in diseases
- Atrial Fibrillation Management and Outcomes
- Acute Myocardial Infarction Research
- Blood groups and transfusion
- Blood properties and coagulation
- Shoulder Injury and Treatment
- Mechanical Circulatory Support Devices
- Cellular transport and secretion
- Hemoglobinopathies and Related Disorders
- Biomarkers in Disease Mechanisms
- Venomous Animal Envenomation and Studies
Inserm
2008-2024
Assistance Publique – Hôpitaux de Paris
2015-2024
Université Paris-Saclay
2017-2024
Hôpital Necker-Enfants Malades
2016-2024
Hemostase Inflammation Thrombosis
2022
Université Paris-Sud
2010-2021
Université Paris Cité
1995-2021
Centre de Recherche sur l'Inflammation
2021
University of Florida
2018
Columbus Oncology and Hematology Associates
2018
Abstract Patients with Wiskott–Aldrich syndrome (WAS) lacking a human leukocyte antigen-matched donor may benefit from gene therapy through the provision of gene-corrected, autologous hematopoietic stem/progenitor cells. Here, we present comprehensive, long-term follow-up results (median follow-up, 7.6 years) (phase I/II trial no. NCT02333760 ) for eight patients WAS having undergone phase lentiviral vector-based trials (nos. NCT01347346 and NCT01347242 ), focus on thrombocytopenia...
Objective: The inability to regulate the inflammatory response initiated upon infection leads severe sepsis, characterized by widespread microvascular injury and thrombosis, organ ischemia, dysfunction. A disintegrin-like metalloprotease with thrombospondin type 1 repeats (ADAMTS)-13 regulates primary hemostasis proteolyzing von Willebrand factor (VWF). Decreased ADAMTS-13 has been reported in disseminated intravascular coagulation due sepsis. present study investigates whether...
Protein S is a vitamin K dependent protein whose inherited deficiency well recognized risk factor for venous thrombosis. Its role to act as activated C cofactor in Va and VIIIa proteolysis, thus restricting thrombin generation. gene lies on chromosome 3, at position 3p11.1-q11.2, its structural organization has been described. Elucidation of the defects responsible proceeding rapidly. A first record identified mutations was undertaken 1996 under auspices International Society Thrombosis...
Objectives. The aim was to assess the efficacy of two intra-tendinous injections platelet-rich plasma (PRP) on epicondylitis recent evolution (≤3 months).
Designing multitarget drugs have raised considerable interest due to their advantages in the treatment of complex diseases such as cancer. Their design constitutes a challenge antitumor drug discovery. The present study reports dual inhibition tubulin polymerization and HDAC activity. On basis 1,1-diarylethylenes ( isoCA-4) belinostat, series hybrid molecules was successfully designed synthesized. In particular compounds, 5f 5h were proven be potent inhibitors both HDAC8 leading excellent...
Growth-arrest-specific protein 6 (Gas6), an intracellular released by apoptotic cells, has been detected in normal plasma. As the Gas6 system implicated mouse susceptibility to sepsis, and as leukocyte apoptosis is thought play a major role physiopathology of human severe we studied plasma levels possibly related variables patients with sepsis.Matched case-control study.Adult intensive care unit university hospital.Thirty 30 organ failure not infection, healthy subjects matched for age...
Research Article19 November 2018Open Access Source DataTransparent process TUBB1 mutations cause thyroid dysgenesis associated with abnormal platelet physiology Athanasia Stoupa INSERM U1016, Faculté de Médecine, Cochin Institute, Université Paris Descartes, Sorbonne Cité, Paris, France IMAGINE Institute Affiliate, RARE Disorder Center: Centre des Maladies Endocriniennes Rares la Croissance et du Développement, Pediatric Endocrinology, Gynecology and Diabetology Unit, Hôpital Universitaire...
Objective: To identify the mechanism of nodular regenerative hyperplasia in HIV-infected patients. Design: Case–control study. Setting: The hepatology and infectious disease units two tertiary care centers France. Patients: We compared 13 consecutive HIV-positive patients with unexplained to 16 without hyperplasia, eight HIV-negative from an identified cause 10 anonymous healthy blood donors. Main outcome measure: Patients controls were screened for diminished protein S activity antiprotein...
Rationale: Severe sepsis is associated with an exacerbated procoagulant state protein C (PC) system impairment. In contrast, the inflammatory and coagulation status of nonseptic patients organ failure (OF) less documented.Objectives: To compare activation, focusing on PC system, in septic OF.Methods: Thirty severe 30 were recruited at onset OF compared matched healthy subjects. We performed extensive analysis pathway, including plasma measurements quantification leukocyte expression...
Purpura fulminans in adults is a rare but devastating disease. Its pathophysiology not well known.To understand the of skin lesions purpura fulminans, interplay between circulating blood and vascular alterations was assessed.Prospective multicenter study four intensive care units. Patients with severe sepsis without were recruited as control subjects.Twenty patients for sampling, biopsy performed deceased patients. High severity disease mortality rates (80%) observed. Skin biopsies revealed...
Formation of platelet plug initiates hemostasis after vascular injury and triggers thrombosis in ischemic disease. However, the mechanisms leading to formation a stable thrombus are poorly understood. Connexins comprise family proteins that form gap junctions enabling intercellular coordination tissue activity, process termed junctional communication.In present study, we show megakaryocytes platelets express connexin 37 (Cx37). Deletion Cx37 gene mice shortens bleeding time increases...