A5003295769- Mitochondrial Function and Pathology
- Adipose Tissue and Metabolism
- Nutrition and Health in Aging
- Muscle metabolism and nutrition
- Autophagy in Disease and Therapy
- ATP Synthase and ATPases Research
- Muscle Physiology and Disorders
- Exercise and Physiological Responses
- Cancer, Lipids, and Metabolism
- Metabolism and Genetic Disorders
- Diet and metabolism studies
- Cancer, Hypoxia, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Ovarian cancer diagnosis and treatment
- Endoplasmic Reticulum Stress and Disease
- Medical and Biological Ozone Research
- RNA modifications and cancer
- Dietary Effects on Health
- Air Quality and Health Impacts
- Frailty in Older Adults
- Physiological and biochemical adaptations
- Chemical Reactions and Isotopes
- Liver Disease Diagnosis and Treatment
- Electromagnetic Fields and Biological Effects
- Advanced MRI Techniques and Applications
Inserm
2012-2025
Université de Tours
2012-2025
Foie, Métabolisme, Cancer
2015-2024
University of Alberta
2023
Centre de recherche Translationnelle en Médecine moléculaire
2019-2023
Centre de Recherche Épidémiologie et Statistique
2018-2019
Université Paris Cité
2018-2019
Sorbonne Paris Cité
2018-2019
Centre Muraz
2017
Université de Montpellier
2017
Significance Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second deadliest cancer by 2030. Advances in therapeutic treatments are urgently required fight against this fatal disease. Here, elucidation of metabolic signature PDAC has identified low-density lipoprotein receptor (LDLR), which facilitates cholesterol uptake, as a promising target. Blocking LDLR reduces proliferative and clonogenic potential cells decreases activation ERK1/2 survival pathway. Moreover,...
Background Aging results in a progressive loss of skeletal muscle, condition known as sarcopenia. Mitochondrial DNA (mtDNA) mutations accumulate with aging muscle and correlate loss, although no causal relationship has been established. Methodology/Principal Findings We investigated the between mtDNA sarcopenia at gene expression biochemical levels using mouse model that expresses proofreading-deficient version (D257A) mitochondrial Polymerase γ, resulting increased spontaneous mutation...
During the aging process, an accumulation of non-heme iron disrupts cellular homeostasis and contributes to mitochondrial dysfunction typical various neuromuscular degenerative diseases. Few studies have investigated effects on integrity function in skeletal muscle liver tissue. Thus, we isolated mitochondria (LM), as well quadriceps-derived subsarcolemmal (SSM) interfibrillar (IFM), from male Fischer 344 x Brown Norway rats at 8, 18, 29 37 months age. Non-heme content SSM, IFM LM was...
Cancer cachexia is a complex syndrome related to negative energy balance resulting in muscle wasting. Implication of mitochondrial bioenergetics alterations during cancer was suggested. Therefore, the aim this study explore efficiency oxidative phosphorylation skeletal mitochondria preclinical model cachexia.Berlin-Druckrey IX rats with peritoneal carcinosis (PC) were used as healthy pair-fed (PF) control. Hindlimb morphology and fibre type composition analysed parallel ubiquitin ligases UCP...
Although identified in several bird species, the biological role of avian homolog mammalian uncoupling proteins (avUCP) remains extensively debated. In present study, functional properties isolated mitochondria were examined physiological or pharmacological situations that induce large changes avUCP expression duckling skeletal muscle. The abundance mRNA, as detected by RT-PCR gastrocnemius muscle but not liver, was markedly increased cold acclimation (CA) hyperthyroidism down-regulated...
Research Article31 March 2015Open Access Source Data Defects in mitophagy promote redox-driven metabolic syndrome the absence of TP53INP1 Marion Seillier Inserm, U1068, CRCM, Marseille, France Institut Paoli-Calmettes, Aix-Marseille Université, CNRS, UMR7258, Search for more papers by this author Laurent Pouyet Prudence N'Guessan Marie Nollet Florence Capo Fabienne Guillaumond Laure Peyta U1069, Nutrition, Croissance et Cancer (N2C), Tours, Jean-François Dumas Annie Varrault UMR5203, U661,...
Background Advanced epithelial ovarian cancer (EOC) patients often receive neoadjuvant platinum-based chemotherapy (NAC), with interval surgery (after three cycles of chemotherapy) considered as a major prognostic factors. We examined how changes in body composition (muscle and adipose tissue) during NAC influence prognosis. Objective Using CT images acquired before cohort women advanced EOC, the aim this study was to analyze fat mass) see whether these parameters, at diagnosis or they...
As immature and aged rats could be more sensitive to ozone (O(3))-linked lung oxidative stress we have attempted shed light on age-related susceptibility O(3) with focusing our interest mitochondrial respiration, reactive oxygen species (ROS) production pro/antioxidant status. For this purpose, exposed fresh air or (500 ppb 12 h per day, for 7 days) 3 week- (immature), 6 month- (adult) 20 month-old (aged). We determined, in lung, H(2)O(2) release by mitochondria, activities of major...
Nonalcoholic fatty liver disease (NAFLD) has become common in Western countries. There is accumulating evidence that mitochondria play a key role NAFLD. Nevertheless, the mitochondrial consequences of steatohepatitis are still unknown. The bioenergetic changes induced methionine- and choline-deficient diet (MCDD) model were studied rats. Liver from MCDD rats exhibited higher rate oxidative phosphorylation with various substrates, rise cytochrome oxidase (COX) activity, an increased content...
Oxidative stress with acute/chronic exercise has been so far examined using involving a combination of concentric and eccentric contractions, but skeletal muscles are likely to be injured greater extent by pliometric contractions. In the present study, effects acute chronic bouts downhill running on mitochondrial hydrogen peroxide (H2O2) generation (fluorimetric detection dimer homovanillic acid in presence horseradish peroxidase) oxygen consumption conjunction antioxidant enzymes activity...