A5033676775- Nutrition and Health in Aging
- Muscle Physiology and Disorders
- Ovarian cancer diagnosis and treatment
- Frailty in Older Adults
- Body Composition Measurement Techniques
- Diet and metabolism studies
- Lipid metabolism and disorders
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Cancer Diagnosis and Treatment
- Oral health in cancer treatment
- Adipose Tissue and Metabolism
- Cancer Risks and Factors
- Bone and Joint Diseases
- Drug Transport and Resistance Mechanisms
Inserm
2020-2025
Université de Tours
2020-2025
UCLouvain
2021-2023
Background Advanced epithelial ovarian cancer (EOC) patients often receive neoadjuvant platinum-based chemotherapy (NAC), with interval surgery (after three cycles of chemotherapy) considered as a major prognostic factors. We examined how changes in body composition (muscle and adipose tissue) during NAC influence prognosis. Objective Using CT images acquired before cohort women advanced EOC, the aim this study was to analyze fat mass) see whether these parameters, at diagnosis or they...
Abstract Background The aryl hydrocarbon receptor (AHR) is expressed in the intestine and liver, where it has pleiotropic functions target genes. This study aims to explore potential implication of AHR cancer cachexia, an inflammatory metabolic syndrome contributing death. Specifically, we tested hypothesis that targeting can alleviate cachectic features, particularly through gut–liver axis. Methods pathways were explored multiple tissues from four experimental mouse models cachexia (C26,...
Cancer cachexia is a multifactorial syndrome characterized by involuntary and pathological weight loss, mainly due to skeletal muscle wasting, resulting in decrease patients' quality of life, response cancer treatments, survival. Our objective was investigate alterations cachectic patients.This prospective study patients managed for pancreatic or colorectal with an indication systemic chemotherapy (METERMUCADIG - NCT02573974). One lumbar CT image used determine body composition. Patients...
Bile acids exert diverse actions on host metabolism and immunity through bile acid-activated receptors, including Takeda G protein-coupled receptor 5 (TGR5). We have recently evidenced an alteration in cancer cachexia, inflammatory metabolic syndrome contributing to death. This current study aims further explore the links emerging between cachexia. First, we showed that flow is reduced cachectic mice. Next, comparing mice inoculated with cachexia-inducing non-cachexia-inducing C26 colon...
Prognostic factors for epithelial ovarian cancers (EOCs) are in particular clinical such as pathology staging at diagnosis (FIGO stages), genetic mutation, or histological phenotypes. In the present study, FIGO stage, tumor residue after surgery, and body mass index were predictors of recurrence-free survival (RFS). Nonetheless, a number studies support lipid metabolism disorder cancer patients. The objective this pilot study was to explore whether fatty acid composition adipose reflecting...