A5014114388- Cancer, Lipids, and Metabolism
- Fatty Acid Research and Health
- Glycosylation and Glycoproteins Research
- Ion channel regulation and function
- Monoclonal and Polyclonal Antibodies Research
- Metabolomics and Mass Spectrometry Studies
- Breast Cancer Treatment Studies
- Diet and metabolism studies
- Cholesterol and Lipid Metabolism
- Mitochondrial Function and Pathology
- Estrogen and related hormone effects
- Cancer, Hypoxia, and Metabolism
- Galectins and Cancer Biology
- Nutritional Studies and Diet
- Ion Channels and Receptors
- Angiogenesis and VEGF in Cancer
- Cancer Risks and Factors
- Nutrition and Health in Aging
- Lipid metabolism and biosynthesis
- Colorectal Cancer Treatments and Studies
- Antimicrobial Peptides and Activities
- Autophagy in Disease and Therapy
- Drug Transport and Resistance Mechanisms
- Proteoglycans and glycosaminoglycans research
- Chemical Reactions and Isotopes
Centre Hospitalier Universitaire de Tours
2015-2025
Hôpital Bretonneau
2012-2025
Université de Tours
2013-2025
Inserm
2015-2025
Cancéropôle Grand Ouest
2019-2024
Clinical Investigation Center Plurithematic Tours
2016-2024
Foie, Métabolisme, Cancer
2005-2019
Centre de recherche Translationnelle en Médecine moléculaire
2019
Centre de Biophysique Moléculaire
2003
Centre National de la Recherche Scientifique
2003
Cancer cachexia is a complex syndrome related to negative energy balance resulting in muscle wasting. Implication of mitochondrial bioenergetics alterations during cancer was suggested. Therefore, the aim this study explore efficiency oxidative phosphorylation skeletal mitochondria preclinical model cachexia.Berlin-Druckrey IX rats with peritoneal carcinosis (PC) were used as healthy pair-fed (PF) control. Hindlimb morphology and fibre type composition analysed parallel ubiquitin ligases UCP...
Abstract Loss of epithelial polarity and gain in invasiveness by carcinoma cells are critical events the aggressive progression cancers depend on phenotypic transition programs such as epithelial-to-mesenchymal (EMT). Many studies have reported aberrant expression voltage-gated sodium channels (Na V ) carcinomas specifically Na 1.5 isoform, encoded SCN5A gene, breast cancer. activity, through an entry ions, cancer is associated with increased invasiveness, but its participation to EMT has be...
Abstract Purpose: To investigate whether dietary docosahexaenoic acid (DHA), a peroxidizable polyunsaturated ω-3 fatty acids, sensitizes rat mammary tumors to anthracyclines and its action interferes with tumor vascularization, critical determinant of growth. Experimental Design: Female Sprague-Dawley rats were initiated by N-methylnitrosourea develop then assigned control group (n = 18), receiving supplementation palm oil, or DHA 54), supplemented microalgae-produced oil (DHASCO, 1.5 g/d)....
// Audrey Gambade 1, * , Sami Zreika 2, Maxime Guéguinou 3 Igor Chourpa 4 Gaëlle Fromont 3, 5 Ana Maria Bouchet Julien Burlaud-Gaillard Marie Potier-Cartereau Sébastien Roger 1 Vincent Aucagne 6 Stéphan Chevalier Christophe Vandier Caroline Goupille 5, Günther Weber 4, Inserm, UMR1069, Nutrition, Croissance et Cancer, Tours, France 2 Department of Medical Lab Technology, Jinan University, Tripoli, Lebanon Ion channel network Canceropole Grand Ouest Université François Rabelais, CHRU Hôpital...
Fucosylated histo-blood group antigens such as Lewis b, Y, and H accumulate in colon carcinoma this is accompanied by a clear increase alpha(1-2)fucosyltransferase activity, key enzyme for the biosynthesis of these antigens. Yet biological significance alpha(1-2) fucosylated structures not well defined. We have transfected poorly tumorigenic rat cell line with human blood cDNA. This resulted surface expression concomitant decrease sialic acid substituted free beta-galactosides....
Accumulation of histo-blood group antigens such as Lewis b, Y and H in colon cancer is indicative poor prognosis. It accompanied by increase α1,2fucosyltransferase activity, a key enzyme for synthesis these antigens. Using model carcinoma, we previously showed that α1,2fucosylation increases tumorigenicity. We now show tumorigenicity inversely correlates with the cells' sensitivity to apoptosis. In addition, poorly tumorigenic REG cells independently transfected three different...
Abstract The proinflammatory chemokine CC ligand 5 (CCL5) is a potent chemoattractant of immature dendritic cells (iDCs). It remains to be elucidated whether CCL5 may also enhance iDC migration through the basement membrane by affecting matrix metalloproteinase (MMP)-9 secretion. In this study, iDCs were differentiated in vitro from human monocytes healthy donors. Zymographic analysis cellular membranes nontreated revealed basal secretion pro- and active MMP-9, whereas only pro-MMP-9 was...
Background Advanced epithelial ovarian cancer (EOC) patients often receive neoadjuvant platinum-based chemotherapy (NAC), with interval surgery (after three cycles of chemotherapy) considered as a major prognostic factors. We examined how changes in body composition (muscle and adipose tissue) during NAC influence prognosis. Objective Using CT images acquired before cohort women advanced EOC, the aim this study was to analyze fat mass) see whether these parameters, at diagnosis or they...
Initially characterized by its antimicrobial activities, LL-37 has also been shown to significantly contribute tumor development. On breast cancer cell lines, increases intracellular calcium via the TRPV2 channel and their migration activation of PI3K/AKT signaling. Its all-d enantiomer d-LL-37 induces similar effects, which excludes a protein-protein interaction in classic ligand-receptor manner. net charge +6 gave rise hypothesis that peptide uses negative charges sulfoglycans or sialic...
While obesity is linked to cancer risk, no studies have explored the consequences of body mass index (BMI) on fatty acid profiles in breast adipose tissue and tumor aggressiveness indicators. Because this, 261 samples women with invasive carcinoma were analyzed. Fatty profile was established by gas chromatography. For normal-weight women, major changes occurs after menopause, enrichment long-chain polyunsaturated acids (LC-PUFAs) both n-6 n-3 series enrichment, but a stable LC-PUFAs n-6/n-3...
The microenvironment of breast epithelial tissue may contribute to the clinical expression cancer. Breast tissue, whether healthy or tumoral, is directly in contact with fat cells, which turn could influence tumor multifocality. In this pilot study we investigated fatty acid composition adipose differed according cancer focality.Twenty-three consecutive women presenting non-metastatic underwent breast-imaging procedures including Magnetic Resonance Imaging prior treatment. specimens were...