A5090294191- Cell Adhesion Molecules Research
- Angiogenesis and VEGF in Cancer
- Autophagy in Disease and Therapy
- Bone Metabolism and Diseases
- MicroRNA in disease regulation
- Signaling Pathways in Disease
- Bone health and treatments
- Systemic Sclerosis and Related Diseases
- Cancer Cells and Metastasis
- Mass Spectrometry Techniques and Applications
- Wnt/β-catenin signaling in development and cancer
- Extracellular vesicles in disease
- Cardiac Ischemia and Reperfusion
- Mesenchymal stem cell research
- Endoplasmic Reticulum Stress and Disease
- Connective Tissue Growth Factor Research
- Pregnancy-related medical research
- Lymphatic System and Diseases
- Studies on Chitinases and Chitosanases
- Apelin-related biomedical research
- Tendon Structure and Treatment
- Pregnancy and preeclampsia studies
- Cancer-related gene regulation
- Glycosylation and Glycoproteins Research
- Congenital heart defects research
Queen Mary University of London
2021-2023
Aix-Marseille Université
2015-2022
Inserm
2015-2022
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2020-2022
Université Côte d'Azur
2014-2022
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2022
Pulmonary Vascular Research Institute
2016-2021
Unité de recherche sur les maladies cardiovasculaires et métaboliques
2018-2021
Institut Paoli-Calmettes
2015
Centre National de la Recherche Scientifique
2015
Bone remodeling is a tightly controlled mechanism in which osteoblasts (OB), the cells responsible for bone formation, osteoclasts (OC), specialized resorption, and osteocytes, multifunctional mechanosensing embedded matrix, are main actors. Increased oxidative stress OB, producing mineralizing has been associated with osteoporosis development but role of autophagy OB not yet addressed. This goal present study. We first show that autophagic process induced during mineralization. Then, using...
Exon skipping mutations of the MET receptor tyrosine kinase (METex14), increasingly reported in cancers, occur 3-4% non-small-cell lung cancer (NSCLC). Only 50% patients have a beneficial response to treatment with MET-tyrosine inhibitors (TKIs), underlying need understand mechanism METex14 oncogenicity and sensitivity TKIs. Whether is driver mutation whether it requires hepatocyte growth factor (HGF) for its range vitro functions vivo has not been fully elucidated from previous preclinical...
Research Article31 March 2015Open Access Source Data Defects in mitophagy promote redox-driven metabolic syndrome the absence of TP53INP1 Marion Seillier Inserm, U1068, CRCM, Marseille, France Institut Paoli-Calmettes, Aix-Marseille Université, CNRS, UMR7258, Search for more papers by this author Laurent Pouyet Prudence N'Guessan Marie Nollet Florence Capo Fabienne Guillaumond Laure Peyta U1069, Nutrition, Croissance et Cancer (N2C), Tours, Jean-François Dumas Annie Varrault UMR5203, U661,...
Endothelial colony-forming cells (ECFC) constitute an endothelial progenitor fraction with a promising interest for the treatment of ischaemic cardiovascular diseases. As soluble CD146 (sCD146) is new factor promoting angiogenesis, we examined whether sCD146 priming could improve therapeutic potential ECFC and defined involved mechanism. We investigated effects on regenerative properties in vivo . In mouse model hindlimb ischaemia, homing radiolabelled to tissue was assessed by SPECT-CT...
CD146 is an adhesion molecule present on many tumors (melanoma, kidney, pancreas, breast, ...). In addition, it has been shown to be expressed vascular endothelial and smooth muscle cells. Generating antibody able specifically recognize in cancer cells (designated as tumor CD146), but not normal cells, would thus of major interest for targeting without affecting the system. We generated antibodies against extracellular domain produced selected that recognizes CD146. This (TsCD146 mAb) was...
Initially discovered in human melanoma, CD146/MCAM is expressed on many tumors and correlated with cancer progression metastasis. However, targeting CD146 remains challenging since it also other cell types, as vessel cells, where displays important physiological functions. We previously demonstrated that shed a soluble form (sCD146) vectorizes the effects of membrane tumor angiogenesis, growth survival. thus generated novel monoclonal antibody, M2J-1 mAb, which specifically targets sCD146,...
Systemic sclerosis (SSc) is an autoimmune disorder characterized by excessive fibrosis, immune dysfunction, and vascular damage, in which the expression of many growth factors deregulated. CD146 was recently described as a major actor SSc. Since also exists circulating soluble form (sCD146) that acts factor numerous angiogenic- inflammation-related pathologies, we sought to identify mechanisms underlying generation sCD146 characterize regulation functions different variants identified SSc.We...
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Abstract Cell-based therapies constitute a real hope for the treatment of ischaemic diseases. One sources endothelial progenitors autologous cell therapy is Endothelial Colony Forming Cells (ECFC) that can be isolated from peripheral blood. However, their use limited by low number in bloodstream and loss stem phenotype associated with acquisition senescent culture. We hypothesized adding soluble CD146, novel growth factor angiogenic properties, during isolation procedures could improve...
CD146 involvement was recently described in skin fibrosis of systemic sclerosis through its regulation the Wnt pathway. Because interaction between and ROS signaling plays a major role fibrosis, we hypothesized that sclerosis, may regulate Wnt/ROS crosstalk. Using transcriptomic western blot analysis performed on wild-type or knockout mouse embryonic fibroblasts, showed procanonical hallmark absence is reversed when expression restored. We found an elevated content cells increase DNA...
This study aimed to develop a PET imaging agent of angiomotin (AMOT) expression, potential biomarker functional tissue regeneration in post-ischaemic conditions. Methods: Hindlimb ischaemia was induced by ligature and resection the right femoral artery mice, clinical score limb perfusion were evaluated up 30 days after surgery. AMOT expression histology Western blot analysis. NODAGA-conjugates ligand, sCD146, designed, synthesised radiolabelled with gallium-68. 68Ga-sCD146 microPET/CT...
The role of CD146 and its soluble form have been intensely reviewed in the processes cancer inflammation. However, how is linked to coagulation thrombotic events remains unclear. aim this paper shed light on topic clarify contribution as a procoagulant factor.
To explore the regulatory role of soluble CD146 (sCD146) and its interaction with galectin-1 (Gal1) in placenta-mediated complications pregnancy.Prospective pilot experimental studies.University-affiliated hospital academic research laboratory.One hundred fifteen women divided into three groups: 30 healthy, nonpregnant women, 50 normal pregnancies, 35 pregnancy complications.Wound-healing experiments were conducted to study trophoblast migration.Quantification sCD146 Gal1 by enzyme-linked...